Indication:

Amiloride and hydrochlorothiazide, a combination of medications, are used alone or in combination with other medications to treat high blood pressure and heart failure in patients who have low amounts of potassium in their bodies or for whom low potassium levels in the body could be dangerous. These medications are in a class of medications called diuretics ('water pills'). They work by causing the kidneys to get rid of unneeded water and salt from the body into the urine. Additionally, amiloride helps to treat or prevent low blood potassium levels. It is important to note that amiloride and hydrochlorothiazide should be used as directed by a healthcare professional and are not recommended for use without medical supervision.

Dosage:

• The combination of amiloride and hydrochlorothiazide comes as a tablet to take by mouth. It is usually taken once a day in the morning with food. To help you remember to take amiloride and hydrochlorothiazide, take it around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand.
• The initial dose typically consists of amiloride 5 mg-hydrochlorothiazide 50 mg orally once a day or in divided doses. The maintenance dose may range from amiloride 5 to 10 mg-hydrochlorothiazide 50 to 100 mg orally once a day or in divided doses. Doses greater than amiloride 10 mg-hydrochlorothiazide 100 mg are usually not needed, and there is little controlled experience with such doses.
• Since hyperkalemia (serum potassium levels greater than 5.5 mEq/L) is potentially fatal if uncorrected, it is essential to monitor serum potassium levels carefully in any patient receiving amiloride and hydrochlorothiazide, particularly during treatment initiation, dose adjustments, and any illness that could affect renal function.

It is crucial to adhere to the prescribed dosage and follow your doctor's instructions regarding any restrictions on food, beverages, or activity. Additionally, it is important to inform your doctor of any other medications you are taking to avoid potential drug interactions.

Please note that the information provided here is a general overview based on the search results and should not replace the specific instructions provided by a healthcare professional.