APIXABAN

INDICATION AND DOSAGE OF APIXABAN

 

What It Is

Apixaban is an oral anticoagulant medication that is used primarily for the prevention and treatment of blood clots. It is a member of a class of drugs known as direct factor Xa inhibitors. By inhibiting factor Xa, apixaban prevents the conversion of prothrombin to thrombin, a key step in the clotting process, thereby reducing the risk of clot formation.

Dosage Forms and Strengths

Apixaban is available in several dosage forms, including:

  • Tablets: The most common dosage forms are 2.5 mg and 5 mg tablets. It is typically administered orally.

Brand and Generic Names

  • Brand Names: Apixaban is marketed under the brand name Eliquis.
  • Generic Names: The generic name is Apixaban.

Indications for Use

Apixaban is used for a variety of indications, including:

  • Prevention of Stroke and Systemic Embolism: In patients with nonvalvular atrial fibrillation.
  • Treatment of Deep Vein Thrombosis (DVT) and Pulmonary Embolism (PE): To prevent recurrence after initial treatment.
  • Prevention of DVT and PE: Following hip or knee replacement surgery.

Mechanism of Action

Apixaban works by selectively inhibiting factor Xa, an essential enzyme in the coagulation cascade. By blocking this enzyme, apixaban prevents the conversion of prothrombin to thrombin, which in turn reduces the formation of fibrin and prevents the formation of new blood clots.

Administration and Dosage

The dosage of apixaban depends on the specific condition being treated, the patient's renal function, and other factors. Common dosing regimens include:

  • For Atrial Fibrillation: The typical dose is 5 mg twice daily. In certain cases, such as in patients with specific risk factors, the dose may be reduced to 2.5 mg twice daily.
  • For DVT and PE: The usual starting dose is 10 mg twice daily for the first seven days, followed by 5 mg twice daily.
  • For Post-Surgery: For hip or knee replacement, the dose is typically 2.5 mg twice daily starting 12 to 24 hours after surgery.

Side Effects and Precautions

Common side effects of apixaban include:

  • Bleeding Complications: As with all anticoagulants, there is a risk of bleeding, including serious or life-threatening bleeding.
  • Anemia: Patients may experience a decrease in hemoglobin levels.

Less common but serious side effects can include:

  • Allergic Reactions: Rash, itching, or swelling.
  • Liver Enzyme Changes: Elevated liver enzymes may occur.

Precautions:

  • Renal and Hepatic Impairment: Dose adjustments may be necessary in patients with significant renal or hepatic impairment.
  • Pregnancy and Lactation: Apixaban is generally not recommended during pregnancy or breastfeeding due to potential risks to the fetus or infant.
  • Drug Interactions: Apixaban may interact with other medications, particularly other anticoagulants or drugs that affect liver enzymes.

Conclusion

Apixaban is a valuable medication in the management of conditions requiring anticoagulation, such as atrial fibrillation, deep vein thrombosis, and pulmonary embolism. Its direct inhibition of factor Xa provides a targeted approach to reducing blood clot risk, and its oral administration offers convenience for long-term therapy. While effective, it is essential for patients to be aware of potential side effects and interact with healthcare professionals to manage dosing and monitor for any adverse effects.

INDICATION AND DOSAGE OF APIXABAN

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APIXABAN TAB 2.5 MG. 10 UNITS ELIQUIS PFIZER (excluded of 20 USD Postage fee/order)
Prophylaxis of venous thromboembolic events following hip replacement surgery, Prophylaxis of venous thromboembolic events following knee replacement surgery
29.01 USD
APIXABAN TAB 5 MG. 10 UNITS ELIQUIS PFIZER (excluded of 20 USD Postage fee/order)
Prophylaxis of venous thromboembolic events following hip replacement surgery, Prophylaxis of venous thromboembolic events following knee replacement surgery
29.01 USD

APIXABAN TAB 2.5 MG. 10 UNITS ELIQUIS PFIZER (excluded of 20 USD Postage fee/order) (ELIQUIS)

Prophylaxis of venous thromboembolic events following hip replacement surgery, Prophylaxis of venous thromboembolic events following knee replacement surgery
29.01 USD

APIXABAN TAB 5 MG. 10 UNITS ELIQUIS PFIZER (excluded of 20 USD Postage fee/order) (ELIQUIS)

Prophylaxis of venous thromboembolic events following hip replacement surgery, Prophylaxis of venous thromboembolic events following knee replacement surgery
29.01 USD

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