What is Cissus Quadrangularis L.?

Cissus quadrangularis L., commonly known as veldt grape, devil's backbone, or adamant creeper, is a perennial plant of the grape family. It is native to parts of Africa, Asia, and the Arabian Peninsula. Traditionally used in Ayurvedic and other forms of herbal medicine, Cissus quadrangularis is renowned for its potential health benefits, particularly in bone health and weight management.

Dosage Forms and Strengths

Cissus quadrangularis is available in various forms, including:

• Capsules: Typically containing 500-1000 mg of the extract per capsule.
• Tablets: Similar in dosage to capsules.
• Powder: Can be mixed with water or other beverages, with dosages ranging from 1-2 grams per serving.
• Liquid Extracts: Concentrated form, with typical dosages varying from a few drops to a teaspoon.

Brand and Generic Names

Cissus quadrangularis is marketed under various brand names and generic formulations. Some popular brand names include:

• Super Cissus by USP Labs
• Cissus RX
• Cissus Power

Generic names simply refer to it as Cissus quadrangularis or Cissus extract.

Indications for Use

Cissus quadrangularis is used for a variety of health conditions, including:

• Bone Health: Promotes bone healing and reduces the risk of fractures.
• Joint Health: Alleviates pain and inflammation associated with arthritis.
• Weight Management: Assists in reducing body fat and improving metabolic health.
• Digestive Health: Treats hemorrhoids, ulcers, and other gastrointestinal issues.
• Antioxidant Properties: Protects against oxidative stress and supports overall health.

Mechanism of Action

The therapeutic effects of Cissus quadrangularis are attributed to its rich content of bioactive compounds, including flavonoids, triterpenoids, and ketosteroids. The primary mechanisms of action include:

• Bone Healing: Enhances osteoblast proliferation and differentiation, promoting faster bone regeneration.
• Anti-inflammatory: Inhibits the production of inflammatory mediators such as prostaglandins and cytokines.
• Antioxidant: Neutralizes free radicals, reducing oxidative stress and cellular damage.
• Weight Management: Modulates enzymes involved in lipid metabolism and inhibits adipogenesis.

Administration and Dosage

The appropriate dosage of Cissus quadrangularis depends on the form and the specific health condition being treated. General guidelines include:

• Capsules/Tablets: 500-1000 mg taken 1-2 times daily with meals.
• Powder: 1-2 grams mixed with water or juice, taken once or twice daily.
• Liquid Extract: 1-2 ml (20-40 drops) taken 1-3 times daily.

It is advisable to start with a lower dose to assess tolerance and gradually increase as needed.

Side Effects and Precautions

Cissus quadrangularis is generally well-tolerated, but some individuals may experience side effects, including:

• Gastrointestinal Distress: Nausea, diarrhea, or stomach cramps.
• Headache: Occasionally reported with high doses.
• Dry Mouth: A common but mild side effect.

Precautions to consider:

• Pregnancy and Breastfeeding: Insufficient evidence on safety; avoid use.
• Pre-existing Conditions: Consult a healthcare provider if you have diabetes, liver, or kidney conditions.
• Medication Interactions: May interact with blood sugar-lowering medications; monitor blood glucose levels closely.

Conclusion

Cissus quadrangularis L. is a versatile and potent herbal supplement with a long history of use in traditional medicine. Its benefits for bone and joint health, weight management, and overall well-being are supported by both traditional wisdom and modern research. While generally safe, it is important to use it appropriately and consult with a healthcare provider, especially if you have underlying health conditions or are taking other medications. As interest in natural health remedies grows, Cissus quadrangularis remains a promising option for those seeking holistic health solutions.