DEXLANSOPRAZOLE

INDICATION AND DOSAGE OF DEXLANSOPRAZOLE

 

Introduction

Dexlansoprazole is a proton pump inhibitor (PPI) used primarily in the management of acid-related gastrointestinal conditions. It is a potent medication designed to reduce stomach acid production, offering relief from symptoms associated with gastroesophageal reflux disease (GERD) and other acid-related disorders. This essay provides a detailed examination of dexlansoprazole, including its dosage forms, brand names, indications, mechanism of action, administration guidelines, side effects, and precautions.

Dosage Forms and Strengths

Dexlansoprazole is available in several dosage forms, predominantly as oral capsules. The strengths commonly available are 30 mg and 60 mg. The capsules are designed to release the medication in a manner that allows for a dual delayed-release effect, which helps in providing sustained acid suppression.

Brand and Generic Names

Dexlansoprazole is marketed under the brand name Dexilant. It is also available in its generic form, which is simply referred to as dexlansoprazole. Both forms are therapeutically equivalent, offering the same efficacy and safety profile.

Indications for Use

Dexlansoprazole is primarily indicated for the treatment of:

  1. Gastroesophageal Reflux Disease (GERD): Dexlansoprazole is used to manage symptoms of GERD, a condition where stomach acid frequently flows back into the esophagus, causing irritation.
  2. Erosive Esophagitis: This condition results from inflammation and damage to the esophagus caused by acid reflux. Dexlansoprazole helps in healing the erosive damage.
  3. Maintenance of Healing: It is also utilized for maintaining the healing of erosive esophagitis and preventing the recurrence of symptoms.

Mechanism of Action

Dexlansoprazole functions as a proton pump inhibitor, which means it inhibits the proton pumps in the gastric parietal cells. These pumps are responsible for secreting gastric acid. By binding to the proton pump, dexlansoprazole blocks the final step in acid production, thereby reducing gastric acid output. This suppression of acid secretion provides symptomatic relief and promotes the healing of the esophagus lining.

Administration and Dosage

Dexlansoprazole is administered orally. The recommended dosage varies based on the condition being treated:

  1. For GERD and Erosive Esophagitis: The usual dose is 60 mg once daily for up to 8 weeks. Maintenance therapy typically involves a dose of 30 mg once daily.
  2. For Maintenance Therapy: The dosage is generally 30 mg once daily.

The medication should be taken before a meal, and the capsules should not be crushed or chewed. The timing of administration is important to ensure effective acid suppression throughout the day.

Side Effects and Precautions

Common side effects of dexlansoprazole include:

  • Headache
  • Diarrhea
  • Nausea
  • Abdominal pain
  • Flatulence

Serious side effects, though less common, can include:

  • Clostridium difficile-associated diarrhea
  • Kidney problems (e.g., acute interstitial nephritis)
  • Bone fractures
  • Low magnesium levels (hypomagnesemia), which can lead to muscle spams, irregular heartbeat, or seizures

Patients should be cautious if they have a history of liver disease, as dexlansoprazole is metabolized by the liver and may require dose adjustment. Long-term use of PPIs like dexlansoprazole has been associated with certain risks, including vitamin B12 deficiency, bone fractures, and renal issues. It is important for patients to use the medication at the lowest effective dose and for the shortest duration necessary.

Conclusion

Dexlansoprazole is an effective proton pump inhibitor used for treating and managing various acid-related gastrointestinal disorders. Its dual delayed-release formulation allows for prolonged acid suppression, aiding in symptom relief and healing of the esophagus. While generally well-tolerated, patients should be aware of potential side effects and use the medication under appropriate medical supervision. Its role in the management of GERD and erosive esophagitis has been well established, making it a valuable tool in the therapeutic arsenal against acid-related diseases.

INDICATION AND DOSAGE OF DEXLANSOPRAZOLE

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DEXLANSOPRAZOLE DR CAP 30 MG 14 UNITS DEXILANT TAKEDA LTD (excluded of 20 USD Postage fee/order)
Dexlansoprazole is used to treat heartburn caused by gastroesophageal reflux disease (GERD) and to heal erosive esophagitis, which is damage to the esophagus from stomach acid.
38.93 USD
DEXLANSOPRAZOLE DR CAP 60 MG 14 UNITS DEXILANT TAKEDA LTD (excluded of 20 USD Postage fee/order)
Dexlansoprazole is a proton pump inhibitor used to treat erosive esophagitis, heartburn, and gastroesophageal reflux disease (GERD).
46.84 USD

DEXLANSOPRAZOLE DR CAP 30 MG 14 UNITS DEXILANT TAKEDA LTD (excluded of 20 USD Postage fee/order) (DEXILANT)

Dexlansoprazole is used to treat heartburn caused by gastroesophageal reflux disease (GERD) and to heal erosive esophagitis, which is damage to the esophagus from stomach acid.
38.93 USD

DEXLANSOPRAZOLE DR CAP 60 MG 14 UNITS DEXILANT TAKEDA LTD (excluded of 20 USD Postage fee/order) (DEXILANT)

Dexlansoprazole is a proton pump inhibitor used to treat erosive esophagitis, heartburn, and gastroesophageal reflux disease (GERD).
46.84 USD
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