EDOXABAN

INDICATION AND DOSAGE OF EDOXABAN

What It Is

Edoxaban is a novel oral anticoagulant (NOAC) used for preventing and treating blood clots. It is a direct factor Xa inhibitor, which means it works by selectively blocking the activity of factor Xa, a crucial component in the blood clotting process. Edoxaban is used to reduce the risk of stroke and systemic embolism in patients with non-valvular atrial fibrillation and to treat and prevent deep vein thrombosis (DVT) and pulmonary embolism (PE).

Dosage Forms and Strengths

Edoxaban is available in oral tablet form. It is commonly offered in three strengths: 30 mg, 60 mg, and 15 mg. The specific dosage prescribed depends on the patient's condition and other factors such as kidney function and body weight.

Brand and Generic Names

The brand name for edoxaban is Savaysa. Its generic name is simply edoxaban. Savaysa is marketed under various brand names in different countries, but the active ingredient remains the same.

Indications for Use

Edoxaban is indicated for several clinical conditions:

  • Non-valvular Atrial Fibrillation (NVAF): To reduce the risk of stroke and systemic embolism in patients with NVAF.
  • Deep Vein Thrombosis (DVT): To treat DVT, including that which is associated with cancer.
  • Pulmonary Embolism (PE): To treat PE and to prevent recurrence of PE and DVT.

Mechanism of Action

Edoxaban works by directly inhibiting factor Xa, an enzyme central to the coagulation cascade. By blocking factor Xa, edoxaban reduces the conversion of prothrombin to thrombin. This action inhibits the formation of fibrin, which is essential for blood clotting. As a result, edoxaban prevents the formation of new blood clots and the growth of existing ones.

Administration and Dosage

Edoxaban is administered orally, with or without food. The standard dosage for most indications is 60 mg once daily. However, in certain populations such as patients with renal impairment, the dose may be reduced to 30 mg once daily. The precise dosage and duration of treatment should be individualized based on patient-specific factors such as renal function, body weight, and concurrent medications.

Side Effects and Precautions

Common side effects of edoxaban include bleeding complications, such as:

  • Gastrointestinal bleeding: Symptoms may include nausea, vomiting, and black stools.
  • Hematuria: Blood in the urine.
  • Hematoma: Swelling or bruising under the skin.
  • Anemia: Low red blood cell count.

Serious but less common side effects include:

  • Severe bleeding: Such as intracranial hemorrhage.
  • Liver enzyme elevations: Liver function tests should be monitored.

Patients should be advised to avoid activities that increase the risk of bleeding. Special caution is necessary for patients with renal impairment, liver disease, or those taking other anticoagulants or medications that affect bleeding risk.

Conclusion

Edoxaban represents a significant advancement in anticoagulant therapy, offering a convenient oral option with predictable dosing and reduced need for routine monitoring compared to traditional anticoagulants like warfarin. Its efficacy in preventing stroke and treating thromboembolic events makes it a valuable tool in managing these serious conditions. However, like all anticoagulants, edoxaban requires careful management to balance efficacy with safety, particularly regarding bleeding risks. As with any medication, patients should use edoxaban under the guidance of a healthcare professional, who will tailor the therapy to their individual needs and circumstances.

INDICATION AND DOSAGE OF EDOXABAN

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EDOXABAN FL TB 15 MG 14 UNITS LIXIANA DAIICHI SANKYO (excluded of 20 USD Postage fee/order)
Edoxaban is an anticoagulant medication used primarily for the prevention of stroke and systemic embolism in patients with non-valvular atrial fibrillation, and for the treatment and prevention of deep vein thrombosis (DVT) and pulmonary embolism (PE).
55.60 USD
EDOXABAN FL TB 30 MG 14 UNITS LIXIANA DAIICHI SANKYO (excluded of 20 USD Postage fee/order)
Edoxaban is an anticoagulant medication used primarily for the prevention of stroke and systemic embolism in patients with non-valvular atrial fibrillation, and for the treatment and prevention of deep vein thrombosis (DVT) and pulmonary embolism (PE).
66.80 USD
EDOXABAN FL TB 60 MG 14 UNITS LIXIANA DAIICHI SANKYO (excluded of 20 USD Postage fee/order)
Edoxaban is an anticoagulant medication used primarily for the prevention of stroke and systemic embolism in patients with non-valvular atrial fibrillation, and for the treatment and prevention of deep vein thrombosis (DVT) and pulmonary embolism (PE).
74.45 USD

EDOXABAN FL TB 15 MG 14 UNITS LIXIANA DAIICHI SANKYO (excluded of 20 USD Postage fee/order) (LIXIANA 15)

Edoxaban is an anticoagulant medication used primarily for the prevention of stroke and systemic embolism in patients with non-valvular atrial fibrillation, and for the treatment and prevention of deep vein thrombosis (DVT) and pulmonary embolism (PE).
55.60 USD

EDOXABAN FL TB 30 MG 14 UNITS LIXIANA DAIICHI SANKYO (excluded of 20 USD Postage fee/order) (LIXIANA 30)

Edoxaban is an anticoagulant medication used primarily for the prevention of stroke and systemic embolism in patients with non-valvular atrial fibrillation, and for the treatment and prevention of deep vein thrombosis (DVT) and pulmonary embolism (PE).
66.80 USD

EDOXABAN FL TB 60 MG 14 UNITS LIXIANA DAIICHI SANKYO (excluded of 20 USD Postage fee/order) (LIXIANA 60)

Edoxaban is an anticoagulant medication used primarily for the prevention of stroke and systemic embolism in patients with non-valvular atrial fibrillation, and for the treatment and prevention of deep vein thrombosis (DVT) and pulmonary embolism (PE).
74.45 USD

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