CILOSTAZOL TAB 100 MG 100 UNITS CILOSOL 100 UNISON

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CILOSTAZOL TAB 100 MG 100 UNITS CILOSOL 100 UNISON

Contents Cilostazol Indications/Uses Symptomatic management of peripheral vascular disease primarily intermittent claudication. Adjunct w/ aspirin & clopidogrel for prevention of stent thrombosis & restenosis after coronary stent placement. Dosage/Direction for Use Adult 100 mg bid. Concomitant use w/ CYP2C19 & CYP3A4 inhibitors Reduce dose to 50 mg bid. Administration Should be taken on an empty stomach: Take at least 30 min before or 2 hr after meals. Contraindications Hypersensitivity. Heart failure. Hemostatic disorders or active bleeding. Pregnancy, lactation. Special Precautions Moderate to severe hepatic & severe renal impairment. Patients receiving other platelet aggregation inhibitors or w/ thrombocytopenia. Discontinue therapy if thrombocytopenia or leukopenia occur. Concomitant use w/ clopidogrel. Withhold for at least 4-6 half-lives prior to elective surgical procedures. Receiving CYP3A4 inhibitors (eg, ketoconazole or erythromycin) or CYP2C19 inhibitors (eg, omeprazole). Severe underlying heart disease. Ped patients. Adverse Reactions Headache; abnormal stools, diarrhea; rhinitis; infection. Drug Interactions Serum conc may be increased by antifungal agents, macrolide antibiotics & omeprazole. Increased conc w/ CYP3A4 or CYP2C19 inhibitors. May potentiate platelet aggregation inhibition of aspirin. Increased bleeding w/ anticoagulants, dasatinib, drotrecogin α, NSAIDs or treprostinil. Decreased levels/effects by CYP3A4 inducers & St. John's wort. Potential inhibition of CYP3A4 w/ grapefruit juice. Avoid alfalfa, anise, bilberry, bladderwrack, bromelain, cat's claw, chamomile, coleus, cordyceps, dong quai, evening primrose oil, fenugreek, feverfew, garlic, ginger, Ginkgo biloba, ginseng (American, Panax, Siberian), grape seed, green tea, guggul, horse chest nut seed, horse radish, licorice, prickly ash, red clover, reishi, sweet clover, turmeric, white willow, S-adenosylmethionine. MIMS Class Anticoagulants, Antiplatelets & Fibrinolytics (Thrombolytics) / Peripheral Vasodilators & Cerebral Activators ATC Classification B01AC23 - cilostazol ; Belongs to the class of platelet aggregation inhibitors excluding heparin. Used in the treatment of thrombosis. Thai FDA Category D

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