RACECADOTRIL

INDICATION AND DOSAGE OF RACECADOTRIL

What It Is:

Racecadotril is an antidiarrheal agent that works as an enkephalinase inhibitor. It helps reduce hypersecretion of water and electrolytes into the intestine, thus reducing diarrhea without affecting intestinal motility. Unlike traditional antidiarrheals, it doesn’t slow down intestinal transit, making it a safer option for treating acute diarrhea, especially in children.

Dosage Forms and Strengths

Racecadotril is available in different forms and strengths depending on the formulation:

  • Capsules: 100 mg
  • Oral Granules: 10 mg and 30 mg, typically for pediatric use
  • Powder for Oral Suspension: Strengths may vary but are typically used for younger children.

Brand and Generic Names

  • Generic Name: Racecadotril
  • Brand Names: Some of the most common brand names include Hidrasec, Tiorfan, and Redotril.

Indications for Use

Racecadotril is primarily used to treat acute diarrhea in both adults and children. It is effective for short-term management but is not recommended for chronic diarrhea. It is especially used for the treatment of acute watery diarrhea, such as that caused by infections.

Mechanism of Action

Racecadotril works by inhibiting the enzyme enkephalinase, which is responsible for breaking down enkephalins, endogenous peptides that reduce fluid secretion in the intestines. By preventing the breakdown of enkephalins, Racecadotril allows these peptides to continue reducing secretion, thus controlling the excessive loss of water and electrolytes without affecting gastrointestinal motility.

Unlike other antidiarrheal agents like loperamide, Racecadotril does not lead to constipation or prolonged bowel transit time, as it acts only on fluid secretion rather than motility.

Administration and Dosage

  • Adults: The typical dose for adults is 100 mg three times a day, usually before meals, until the diarrhea is controlled.
  • Children: For children, the dosage is based on body weight. The oral granules (10 mg or 30 mg) are commonly prescribed, with the typical dose being 1.5 mg/kg per dose three times a day.

Racecadotril is usually given orally and can be taken with or without food. Treatment duration depends on the persistence of diarrhea but should not extend beyond 7 days.

Side Effects and Precautions

Racecadotril is generally well tolerated, but like any medication, it may cause side effects:

  • Common side effects: Headache, skin reactions (e.g., rash, erythema), nausea, and vomiting.
  • Rare side effects: Hypersensitivity reactions, such as angioedema or anaphylaxis, can occur.

Precautions:

  • Allergies: Patients who are allergic to Racecadotril or any of its components should not use it.
  • Kidney or liver impairment: Caution is recommended for patients with significant renal or hepatic dysfunction.
  • Pregnancy and breastfeeding: There is limited data on the safety of Racecadotril during pregnancy and breastfeeding, so it should be used with caution and under medical advice.
  • Chronic diarrhea: Racecadotril is not indicated for chronic forms of diarrhea, and its use should be limited to acute cases.

Conclusion

Racecadotril is an effective and safe treatment for acute diarrhea, especially in children, due to its ability to reduce excessive fluid secretion without impacting intestinal motility. Its well-tolerated profile and minimal risk of serious side effects make it a valuable option for treating acute diarrhea. However, it should be used cautiously in individuals with kidney or liver issues, and it’s important to seek medical advice for prolonged or chronic diarrhea.

INDICATION AND DOSAGE OF RACECADOTRIL

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RACECADOTRIL CAP 100 MG 10 UNITS HIDRASEC ABBOTT LABORATORIE (excluded of 20 USD Postage fee/order)
Racecadotril is indicated for the treatment of acute diarrhea in adults and children.
37.00 USD

RACECADOTRIL CAP 100 MG 10 UNITS HIDRASEC ABBOTT LABORATORIE (excluded of 20 USD Postage fee/order) (HIDRASEC)

Racecadotril is indicated for the treatment of acute diarrhea in adults and children.
37.00 USD
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