Tacrolimus is a medication used in the prevention and treatment of solid-organ transplant rejection. It belongs to the calcineurin-inhibitor class of medications. Here is some information regarding the indication and dosage of tacrolimus:

Indication:

Tacrolimus is indicated for the following conditions:

• Prevention and treatment of solid-organ transplant rejection, such as kidney, liver, heart, or lung transplants.
• It may be used in combination with other medications, such as steroids, azathioprine, basiliximab, or mycophenolate mofetil.

Dosage:

The dosage of tacrolimus can vary depending on various factors, including the type of transplant, patient's age, weight, and individual response. It is important to follow the specific dosage instructions provided by your healthcare provider. Here are some general dosage guidelines:

• Tacrolimus is available in different formulations, including immediate-release capsules, extended-release capsules, and ointment. It is important not to switch between different forms of tacrolimus without consulting your doctor.
• The dosage of tacrolimus is usually individualized based on therapeutic drug monitoring, which involves monitoring the blood concentration of tacrolimus.
• For the prevention of organ rejection in kidney transplant patients, the initial recommended oral dosage is usually around 0.1 to 0.2 mg/kg/day, divided into two doses.
• The dosage may be adjusted based on the patient's response, graft function, and drug interactions.
• It is important to take tacrolimus exactly as directed by your doctor. Do not take more or less of it and do not take it more often than prescribed.

Please note that these are general dosage guidelines, and individual dosing may vary. It is essential to consult with your healthcare provider for personalized dosage instructions and any specific precautions or considerations based on your individual circumstances.