TEGAFUR & URACIL

INDICATION AND DOSAGE OF TEGAFUR & URACIL

1. Tegafur + Uracil

Tegafur + Uracil is a combination chemotherapy drug used in the treatment of various cancers, particularly colorectal cancer. Tegafur is a prodrug of 5-fluorouracil (5-FU), an antimetabolite that interferes with DNA synthesis, while Uracil is included to enhance the efficacy of Tegafur by inhibiting the enzyme that breaks down 5-FU, leading to sustained therapeutic levels.

2. Dosage Forms and Strengths

Tegafur + Uracil is typically available in capsule form, with varying concentrations depending on the specific treatment plan. Common strengths include:

  • Tegafur 100 mg / Uracil 224 mg
  • Tegafur 50 mg / Uracil 112 mg

3. Brand and Generic Names

  • Brand Names: UFT, Ftorafur-Uracil
  • Generic Names: Tegafur and Uracil combination

4. Indications for Use

Tegafur + Uracil is primarily indicated for the treatment of:

  • Colorectal cancer (stage II and III)
  • Gastric cancer
  • Breast cancer (off-label in some regions)

It may also be used in adjuvant therapy following surgery to reduce the risk of cancer recurrence.

5. Mechanism of Action

Tegafur is a prodrug of 5-fluorouracil (5-FU), which inhibits thymidylate synthase, an enzyme necessary for the synthesis of thymidine, a nucleoside required for DNA replication. By inhibiting DNA synthesis, the drug prevents the growth and proliferation of cancer cells. Uracil works synergistically by inhibiting the enzyme dihydropyrimidine dehydrogenase (DPD), which degrades 5-FU, allowing for a prolonged and sustained action of the drug in the system.

6. Administration and Dosage

  • Administration: Tegafur + Uracil is administered orally, usually in capsule form.
  • Dosage: The dosage varies depending on the specific cancer being treated, patient condition, and the treatment regimen. A common regimen for colorectal cancer is 300-400 mg of Tegafur per square meter of body surface area per day, divided into two or three doses. It is usually taken continuously for several weeks with a rest period to allow the body to recover.

7. Side Effects and Precautions

Common Side Effects:

  • Nausea and vomiting
  • Diarrhea
  • Stomatitis (mouth sores)
  • Fatigue
  • Anorexia

Serious Side Effects:

  • Myelosuppression (bone marrow suppression), leading to leukopenia, anemia, or thrombocytopenia
  • Hepatotoxicity (liver damage)
  • Gastrointestinal perforation or bleeding

Precautions:

  • Monitoring: Regular monitoring of blood counts and liver function is essential during treatment.
  • Renal or Hepatic Impairment: Dose adjustment may be required in patients with kidney or liver problems.
  • Pregnancy and Lactation: Tegafur + Uracil is contraindicated in pregnancy due to the risk of fetal harm. Breastfeeding is also not recommended during treatment.

8. Conclusion

Tegafur + Uracil is an effective combination chemotherapy used in the treatment of colorectal and other cancers. The inclusion of Uracil enhances the therapeutic efficacy of Tegafur by prolonging the action of its active metabolite, 5-FU. While it offers significant benefits in cancer treatment, careful monitoring is required due to the potential for serious side effects, particularly bone marrow suppression and liver damage. This regimen plays a crucial role in cancer care, particularly as an adjuvant therapy post-surgery to improve survival rates and reduce recurrence risks.

INDICATION AND DOSAGE OF TEGAFUR & URACIL

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TEGAFUR URACIL CAP 10 UNITS UFUR TTY BIOPHARMA (excluded of 20 USD Postage fee/order)
Remission of subjective & objective symptoms in head & neck, gastric, colorectal, liver, gallbladder, bile duct, pancreatic, lung, breast, bladder, prostatic & uterine cervical cancers. CRC in combination w/ folinate.
33.20 USD

TEGAFUR URACIL CAP 10 UNITS UFUR TTY BIOPHARMA (excluded of 20 USD Postage fee/order) (UFUR)

Remission of subjective & objective symptoms in head & neck, gastric, colorectal, liver, gallbladder, bile duct, pancreatic, lung, breast, bladder, prostatic & uterine cervical cancers. CRC in combination w/ folinate.
33.20 USD
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