Indication:

Ticagrelor, marketed under the brand name Brilinta, is indicated for the following:

• Reducing the risk of a first myocardial infarction (MI) or stroke in patients with coronary artery disease (CAD) at high risk for such events.
• Reducing the risk of cardiovascular death, MI, and stroke in patients with acute coronary syndrome (ACS) or a history of MI.
• Lowering the risk of blood clots in individuals with CAD who have been treated with stents to open clogged arteries.
• The efficacy of ticagrelor was established in a population with type 2 diabetes, although its use is not limited to this setting.

Dosage:

• The typical dosage of ticagrelor is an initial dose of 180 mg, followed by a maintenance dose of 90 mg twice daily. This regimen is often used in combination with a daily maintenance dose of aspirin (75-100 mg).
• For patients who have had a heart attack, a lower dose of 60 mg twice daily may be prescribed for up to 3 years after the initial 12-month course of treatment.
• Ticagrelor should be taken exactly as directed by a healthcare professional. It is important not to take less or more than directed, as this may affect its effectiveness and increase the risk of serious side effects.
• The use of ticagrelor in patients with moderate hepatic impairment should be carefully considered due to the potential increase in exposure to the medication. No dosage adjustment is needed in patients with mild hepatic impairment.
• Ticagrelor should be administered with caution in patients with renal impairment, and no dosage adjustment is needed in such cases.
• It is important to inform the healthcare provider about all medications being taken, as some medications may interact with ticagrelor, affecting its dosage and effectiveness.

It's crucial to note that ticagrelor may cause increased bleeding and bruising, and it is important to follow the healthcare provider's instructions regarding its use, especially in the context of surgical procedures.

As with any medication, it is advisable to consult with a healthcare professional for personalized advice and guidance regarding the indication and dosage of ticagrelor based on the specific medical condition.