TOLPERISONE

INDICATION AND DOSAGE OF TOLPERISONE

Tolperisone is a centrally acting muscle relaxant used to alleviate muscle spasticity and associated conditions. It is often prescribed for managing muscle spasm and spasticity related to neurological disorders, including stroke and multiple sclerosis. Tolperisone is known for its effectiveness in reducing muscle tone and improving mobility.

Dosage Forms and Strengths

Tolperisone is available in oral tablet form. Common dosage strengths include:

  • 50 mg Tablets: Typically used as an initial dose or in lower doses to manage muscle spasticity.
  • 150 mg Tablets: Often used for more severe cases or when higher doses are necessary for effective relief.

In some regions, Tolperisone might also be available in extended-release formulations, which provide a prolonged effect.

Brand and Generic Names

Tolperisone is marketed under various brand names worldwide. Some of the common brand names include:

  • Mydocalm: One of the most widely recognized brands.
  • Tolperisone: Used as a generic name in several countries.

The availability of Tolperisone under these brand names can vary by country and manufacturer.

Indications for Use

Tolperisone is primarily indicated for:

  • Muscle Spasticity: Effective in conditions where muscle spasticity is a prominent symptom, such as in multiple sclerosis, stroke, or spinal cord injuries.
  • Muscle Spasms: Used to relieve acute muscle spasms and associated pain.

It is often used as part of a comprehensive treatment plan that may include physical therapy and other medications.

Mechanism of Action

Tolperisone's exact mechanism of action is not fully understood, but it is believed to involve several pathways:

  • Central Nervous System Effects: Tolperisone is thought to act primarily within the central nervous system (CNS). It may reduce muscle tone by inhibiting the activity of specific neurons in the spinal cord and brainstem.
  • Muscle Relaxation: By modulating the release of neurotransmitters and reducing neuronal excitability, Tolperisone helps to decrease muscle spasticity and improve muscle relaxation.
  • Peripheral Actions: It may also have direct effects on the peripheral nervous system, contributing to its muscle relaxant properties.

Administration and Dosage

Tolperisone is administered orally, typically in the form of tablets. The usual dosage recommendations are:

  • Initial Dose: 50 mg to 150 mg daily, divided into two or three doses.
  • Maintenance Dose: Depending on the patient's response and tolerance, the dose may be adjusted. The typical dose ranges from 150 mg to 300 mg per day.

The exact dosage and frequency should be tailored to individual needs and adjusted based on the patient's response and any side effects.

Effects and Precautions

Effects:

  • Primary Effects: Reduction in muscle spasticity, decreased muscle tone, and improvement in mobility.
  • Secondary Effects: Relief from muscle pain and discomfort associated with spasticity.

Precautions:

  • Contraindications: Tolperisone should be avoided in patients with known hypersensitivity to the drug or its components.
  • Pregnancy and Lactation: Use with caution during pregnancy and breastfeeding. The effects on the fetus and infant are not well-studied.
  • Drug Interactions: Tolperisone may interact with other CNS depressants, leading to increased sedation. Caution is advised when used in conjunction with alcohol or other medications that depress the CNS.
  • Side Effects: Common side effects may include dizziness, headache, fatigue, and gastrointestinal disturbances. Severe reactions are rare but may include allergic reactions or liver function abnormalities.

Conclusion

Tolperisone is a valuable medication for managing muscle spasticity and associated conditions. Its central muscle relaxant effects make it an effective option for patients suffering from neurological disorders leading to muscle spasm and stiffness. Proper dosing and monitoring are crucial to maximize its benefits while minimizing potential side effects and interactions. As with any medication, it is important to follow medical advice and adjust treatment based on individual responses and health conditions.

 

INDICATION AND DOSAGE OF TOLPERISONE

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TOLPERISONE FILM-COAT TB 150 MG 10 UNITS MYDOCALM GEDEON RICHTER (excluded of 20 USD Postage fee/order)
Tolperisone is used for the treatment of conditions involving increased tone of the skeletal muscle caused by neurological diseases, spastic paralysis, and other encephalopathies manifested with muscular dystonia.
6.10 USD
TOLPERISONE FILM-COAT TB 50 MG 10 UNITS BIOCALM BIOLAB (excluded of 20 USD Postage fee/order)
Tolperisone is used for the treatment of conditions involving increased tone of the skeletal muscle caused by neurological diseases, spastic paralysis, and other encephalopathies manifested with muscular dystonia.
3.87 USD
TOLPERISONE TAB 50 MG 10 UNITS MYOXAN T.O.CHEMICAL (excluded of 20 USD Postage fee/order)
Tolperisone is used for the treatment of conditions involving increased tone of the skeletal muscle caused by neurological diseases, spastic paralysis, and other encephalopathies manifested with muscular dystonia.
3.87 USD
TOLPERISONE TAB SC 50 MG 10 UNITS MYDOCALM UNISON (excluded of 20 USD Postage fee/order)
Tolperisone is used for the treatment of conditions involving increased tone of the skeletal muscle caused by neurological diseases, spastic paralysis, and other encephalopathies manifested with muscular dystonia.
4.29 USD

TOLPERISONE FILM-COAT TB 150 MG 10 UNITS MYDOCALM GEDEON RICHTER (excluded of 20 USD Postage fee/order) (MYDOCALM)

Tolperisone is used for the treatment of conditions involving increased tone of the skeletal muscle caused by neurological diseases, spastic paralysis, and other encephalopathies manifested with muscular dystonia.
6.10 USD

TOLPERISONE FILM-COAT TB 50 MG 10 UNITS BIOCALM BIOLAB (excluded of 20 USD Postage fee/order) (BIOCALM)

Tolperisone is used for the treatment of conditions involving increased tone of the skeletal muscle caused by neurological diseases, spastic paralysis, and other encephalopathies manifested with muscular dystonia.
3.87 USD

TOLPERISONE TAB 50 MG 10 UNITS MYOXAN T.O.CHEMICAL (excluded of 20 USD Postage fee/order) (MYOXAN)

Tolperisone is used for the treatment of conditions involving increased tone of the skeletal muscle caused by neurological diseases, spastic paralysis, and other encephalopathies manifested with muscular dystonia.
3.87 USD

TOLPERISONE TAB SC 50 MG 10 UNITS MYDOCALM UNISON (excluded of 20 USD Postage fee/order) (MYDOCALM)

Tolperisone is used for the treatment of conditions involving increased tone of the skeletal muscle caused by neurological diseases, spastic paralysis, and other encephalopathies manifested with muscular dystonia.
4.29 USD
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