TRIFLUOPERAZINE

INDICATION AND DOSAGE OF TRIFLUOPERAZINE

What it is


Trifluoperazine is a first-generation antipsychotic medication belonging to the phenothiazine class. It is primarily used to treat various psychiatric disorders, especially schizophrenia and other severe psychotic conditions. Trifluoperazine is known for its potent dopamine receptor-blocking effects, making it effective in reducing symptoms like hallucinations, delusions, and agitation. It is also sometimes used to manage anxiety on a short-term basis.


Dosage Forms and Strengths


Trifluoperazine is available in several forms and strengths to accommodate different patient needs:

  • Oral tablets: Commonly available in strengths of 1 mg, 2 mg, 5 mg, and 10 mg.
  • Oral solution: Available for patients who have difficulty swallowing tablets.
  • Injectable form (IM): Typically used in clinical or hospital settings for rapid management of psychosis.

Brand and Generic Names

 

  • Generic Name: Trifluoperazine
  • Brand Names: Stelazine (the most recognized brand name, though availability can vary by region).

Indications for Use


Trifluoperazine is indicated for several psychiatric and psychological conditions, including:

  • Schizophrenia: It is used to manage both the acute and chronic phases of schizophrenia, reducing symptoms such as hallucinations, delusions, and disorganized thinking.
  • Short-term anxiety: In lower doses, it is sometimes prescribed for anxiety management, though this use has become less common due to the availability of newer medications with fewer side effects.
  • Other off-label uses: Occasionally used for other psychiatric conditions such as severe agitation and certain mood disorders.

Mechanism of Action


Trifluoperazine works by blocking dopamine receptors, primarily D2 receptors, in the brain. Dopamine is a neurotransmitter involved in mood regulation, reward pathways, and psychotic behavior. By inhibiting dopamine’s action, trifluoperazine reduces the intensity of psychotic symptoms like hallucinations and delusions. The drug also exhibits some antihistaminic and anticholinergic effects, which contribute to its side effect profile.


Administration and Dosage


The dosage of trifluoperazine is individualized based on the severity of the condition and patient response:

  • For schizophrenia: The starting dose typically ranges from 2 mg to 5 mg twice daily, with maintenance doses adjusted based on therapeutic response. The maximum daily dose can go up to 40 mg in severe cases, though doses above 20 mg are generally avoided due to an increased risk of side effects.
  • For anxiety: A lower dose, usually 1 mg to 2 mg twice daily, is prescribed for short-term use. Long-term use for anxiety is generally discouraged due to the risk of side effects, especially in light of safer alternatives.
  • Administration: It is usually taken orally with or without food. Injectable forms are reserved for acute psychiatric emergencies or patients unable to take oral medication.

Effects and Precautions

Common side effects:

  • Drowsiness
  • Dizziness
  • Dry mouth
  • Blurred vision
  • Weight gain

Serious side effects:

  • Extrapyramidal symptoms (EPS): Involuntary muscle movements, tremors, stiffness, and restlessness are common in patients on trifluoperazine due to its potent dopamine-blocking effects.
  • Tardive dyskinesia: A more severe form of EPS, characterized by repetitive, involuntary movements, particularly of the face and tongue. This is often irreversible.
  • Neuroleptic malignant syndrome (NMS): A rare but life-threatening condition that can occur with the use of antipsychotic medications like trifluoperazine. Symptoms include muscle rigidity, fever, altered mental status, and autonomic dysfunction.

Precautions:

  • Elderly patients with dementia-related psychosis: The use of trifluoperazine increases the risk of death in this population.
  • Patients with cardiovascular disease: The drug may cause orthostatic hypotension and other heart-related issues, so caution is advised.
  • Pregnancy and breastfeeding: Trifluoperazine should be used with caution during pregnancy and is generally not recommended during breastfeeding due to the risk of adverse effects on the newborn.

Conclusion


Trifluoperazine is a potent first-generation antipsychotic that is highly effective in treating schizophrenia and, to a lesser extent, short-term anxiety. While it offers significant benefits in controlling psychotic symptoms, its use comes with notable side effects, particularly movement disorders and the risk of long-term complications like tardive dyskinesia. Modern antipsychotics with fewer side effects have made trifluoperazine less commonly used, but it remains a valuable option for certain patients when newer medications are not effective. As with all antipsychotics, close monitoring and individualized dosing are essential to minimize risks and maximize therapeutic benefits.

INDICATION AND DOSAGE OF TRIFLUOPERAZINE

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TRIFLUOPERAZINE TAB SC 5 MG 10 UNITS TRIFLAZINE GPO (excluded of 20 USD Postage fee/order)
TRIFLUOPERAZINE is medicated for schizophrenia and anxiety in individuals who have not been helped by other treatments.
3.51 USD

TRIFLUOPERAZINE TAB SC 5 MG 10 UNITS TRIFLAZINE GPO (excluded of 20 USD Postage fee/order) (TRIFLAZINE)

TRIFLUOPERAZINE is medicated for schizophrenia and anxiety in individuals who have not been helped by other treatments.
3.51 USD
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