Indication:

Vigabatrin is indicated for the treatment of the following conditions:

• Refractory complex partial seizures in patients 2 years of age and older who have had inadequate responses to multiple previous treatments.
• Monotherapy for pediatric patients with infantile spasms 1 month to 2 years of age for whom the potential benefits outweigh the potential risk of vision loss.

Dosage:

The dosage of Vigabatrin is based on the indication, age group, weight, and dosage form. Here are some general dosage guidelines based on the indications:

• For refractory complex partial seizures:

  • Adults (17 years of age and older): Start at 1000 mg/day (500 mg twice daily). Increase the total daily dose weekly in 500 mg/day increments, up to the recommended dose of 3000 mg/day (1500 mg twice daily).
  • Pediatric patients (2 to 16 years of age): The recommended dosage is based on body weight and administered as two divided doses.

• For infantile spasms:

  • Vigabatrin for oral solution is indicated as monotherapy for pediatric patients with infantile spasms 1 month to 2 years of age. The dosage should be determined based on the patient's specific condition and the potential risk of vision loss.

It's important to note that Vigabatrin is associated with the risk of permanent vision damage, including loss of peripheral vision and blurry vision. Therefore, the use of Vigabatrin should be carefully considered, and patients should be monitored for any signs of vision-related symptoms.

Please consult a healthcare professional for personalized dosage recommendations and to ensure the safe and effective use of Vigabatrin.

Remember, this information is not exhaustive, and it is essential to consult a healthcare professional before taking any medication or changing your treatment regimen.