Terazosin

Benefit:

Terazosin is a medication primarily used to treat hypertension (high blood pressure) and benign prostatic hyperplasia (BPH), a non-cancerous enlargement of the prostate gland in men. It belongs to a class of medications known as alpha-1 blockers or alpha-adrenergic blockers.

Terazosin works by blocking the action of alpha-1 adrenergic receptors in the blood vessels and prostate gland. By blocking these receptors, terazosin causes the blood vessels to relax and dilate, which leads to a decrease in blood pressure. In men with BPH, terazosin helps relax the muscles in the prostate gland and bladder neck, relieving symptoms such as urinary hesitancy, urgency, and weak urine flow.

Terazosin is typically taken orally in the form of tablets. It is usually started at a low dose and gradually increased as needed to achieve the desired blood pressure or symptom control. It is important to take terazosin exactly as prescribed by a healthcare professional and to follow any instructions regarding dose adjustments carefully.

Side Effect:

Common side effects of terazosin may include dizziness, lightheadedness, drowsiness, headache, and nasal congestion. These side effects are usually mild and temporary but may be more pronounced when starting treatment or increasing the dose. Rare but more serious side effects may include fainting, irregular heartbeat, and low blood pressure.

Terazosin is generally considered safe and effective for most people when used as directed. However, it may not be suitable for everyone, especially those with certain medical conditions or who are taking certain medications. It's important to discuss the potential risks and benefits of terazosin with a healthcare professional before starting treatment

Trenbolone Acetate

BENEFIT:

Trenbolone acetate is an injectable (generally) anabolic steroid derived from nandrolone. Its activity is quite removed from its structural parent, however, such that direct comparisons between the two are difficult. Trenbolone is a non-estrogenic steroid, and is considerably more anabolic and androgenic than nandrolone on a milligram for milligram basis. In appearance, it is much more commonly compared to a stronger androgen such as drostanolone, than it is to nandrolone. It is also estimated to display about three times more androgenic potency than testosterone, making it one of the strongest injectable anabolic steroids ever commercially manufactured. Among athletes, this steroid is highly valued for its ability to increase muscle hardness, definition, and raw strength, without unwanted water retention and fat mass gains. It is considered a drug of choice for contest bodybuilders, yet remains very popular with recreational users simply looking to refine their physiques.

SIDE EFFECT:

1 – Estrogenic issue:

Trenbolone is not aromatized by the body, and is not measurably estrogenic. It is of note, however, that this steroid displays significant binding affinity for the progesterone receptor (slightly stronger than progesterone itself ).505 506 The side effects associated with progesterone are similar to those of estrogen, including negative feedback inhibition of testosterone production and enhanced rate of fat storage. Progestins also augment the stimulatory effect of estrogens on mammary tissue growth. There appears to be a strong synergy between these two hormones here, such that gynecomastia might even occur with the help of progestins, without excessive estrogen levels. The use of an antiestrogen, which inhibits the estrogenic component of this disorder, is often sufficient to mitigate gynecomastia caused by progestational anabolic/androgenic steroids. Note that progestational side effects are more common when trenbolone is being taken with other aromatizable steroids.

2 – Androgenic issue:

Although classified as an anabolic steroid, trenbolone is sufficiently androgenic. Androgenic side effects are still common with this substance, and may include bouts of oily skin, acne, and body/facial hair growth. Anabolic/androgenic steroids may also aggravate male pattern hair loss. Women are also warned of the potential virilizing effects of anabolic/androgenic steroids. These may include a deepening of the voice, menstrual irregularities, changes in skin texture, facial hair growth, and clitoral enlargement. Additionally, the 5-alpha reductase enzyme does not metabolize trenbolone,507 so its relative androgenicity is not affected by finasteride or dutasteride.

3 – Hepatotoxicity issue:

Trenbolone is not c-17 alpha alkylated, and is generally not considered a hepatotoxic steroid; liver toxicity is unlikely. This steroid does have a strong level of resistance to hepatic breakdown, however, and severe liver toxicity has been noted in bodybuilders abusing trenbolone.508 Although unlikely, hepatotoxicity cannot be completely excluded, especially with high doses.

4 – Cardiovascular issue:

Anabolic/androgenic steroids can have deleterious effects on serum cholesterol. This includes a tendency to reduce HDL (good) cholesterol values and increase LDL (bad) cholesterol values, which may shift the HDL to LDL balance in a direction that favors greater risk of arteriosclerosis. The relative impact of an anabolic/androgenic steroid on serum lipids is dependant on the dose, route of administration (oral vs. injectable), type of steroid (aromatizable or nonaromatizable), and level of resistance to hepatic metabolism. Due to its non-aromatizable nature and strong resistance to metabolism, trenbolone has a moderate to strong (negative) impact on lipid values and atherogenic risk. Anabolic/androgenic steroids may also adversely affect blood pressure and triglycerides, reduce endothelial relaxation, and support left ventricular hypertrophy, all potentially increasing the risk of cardiovascular disease and myocardial infarction. To help reduce cardiovascular strain it is advised to maintain an active cardiovascular exercise program and minimize the intake of saturated fats, cholesterol, and simple carbohydrates at all times during active AAS administration. Supplementing with fish oils (4 grams per day) and a natural cholesterol/antioxidant formula such as Lipid Stabil or a product with comparable ingredients is also recommended.

5 - Testosterone Suppression issue:

All anabolic/androgenic steroids when taken in doses sufficient to promote muscle gain are expected to suppress endogenous testosterone production. Without the intervention of testosterone-stimulating substances, testosterone levels should return to normal within 1-4 months of drug secession. Note that prolonged hypogonadotrophic hypogonadism can develop secondary to steroid abuse, necessitating medical intervention. In experimental studies, trenbolone was determined to be approximately three times stronger at suppressing gonadotropins than testosterone on a milligram for milligram basis.

Dose:

Male:

Trenbolone acetate was never approved for use in humans. Prescribing guidelines are unavailable. An effective dosage for physique- or performance-enhancing purposes generally falls in the range of 100-300 mg per week, taken for 6 to 8 weeks. Due to the short-acting nature of acetate esters, the total week’s dosage is subdivided into 2-3 smaller applications. Effective oral doses tend to fall in the range of 100-200 mg per day, taken for no longer than 6-8 weeks to minimize any potential hepatic strain. This level is sufficient to notice strong increases in strength and lean tissue mass, with a low level of unwanted side effects. Lack of estrogenic activity has made trenbolone very appealing for competitive athletes looking to shed fat, while at the same time trying to avoid water retention. Here, trenbolone may provide the high androgen content needed in order to elicit a very hard, defined physique. While it is a noteworthy hardening agent, this is not the only benefit of trenbolone acetate. It is also a strong anabolic, with muscle-building properties often compared to testosterone and Dianabol, but without the same level of water retention. This may be a little generous of a description, as its lack of estrogenic activity does seem to hurt this agent in its abilities to promote muscle mass gains. While trenbolone is often recommended as a great addition to a mass cycle, it is rarely reported to be a very powerful agent when used alone. Results are most often reported as moderate lean tissue growth accompanied by exceptional hardening and fat loss. Although perhaps it is not quite as potent as the more estrogenic bulking agents if sheer mass is the goal, trenbolone is still a better builder milligram for milligram than nandrolone, and likely the most anabolic of all the non-estrogenic commercial steroids. For stacking, trenbolone is a very versatile steroid, and seems to work exceptionally well with other agents for both bulking and cutting purposes. For cutting, bodybuilders often stack it with a mild anabolic like Winstrol® or Primobolan®. Without extra water beneath your skin, the mix will elicit a very solid, well-defined hardness to the physique. For lean mass gains, Deca-Durabolin® or Equipoise® are popular additions. Here again, trenbolone will greatly enhance and solidify the new muscle growth. When looking purely for mass, trenbolone pairs well with testosterone, Anadrol 50®, or Dianabol.The result is typically the rapid and substantial gain of somewhat solid muscle mass. In the Underground Steroid Hanbook II, Dan Duchaine describes the mix of trenbolone, testosterone, and Anadrol as the “Most Effective” stack for men, and states, “I’ve not encountered any other stack that will put weight and strength on like this one.” This particular drug combination has subsequently become quite popular.

Female:

Trenbolone acetate was never approved for use in humans. Prescribing guidelines are unavailable. This agent is not recommended for women for physique- or performanceenhancing purposes due to strong androgenic nature and tendency to produce virilizing side effects.

Testosterone Cypionate

Alternative Names:

Testosterone Cipionate,Testosterone Cyclopenthylpropionate

Proprietary Names:

Andro-Cyp (100, 200 mg./ml),Depo-Testosterone (50, 100, 200 mg./ml),Depotest (100 mg., 200 mg./ml.),Duratest (100, 200 mg./ml.),Testa-C (200 mg./ml.),Testes Leo (100, 250 mg./2 ml.)

Description:

Testosterone Cypionate is an ester of testosterone with high anabolic and androgenic properties. It is oil based and therefore long acting. The common side-effects of Cypionate are mostly associated with its high androgenic component, testicular atrophy, reduced spermatogenesis and aromatization.

BENEFIT:

1 - Testosterone cypionate is a slow-acting injectable ester of the primary male androgen testosterone. Testosterone is also the principle anabolic hormone in men, and is the basis of comparison by which all other anabolic/androgenic steroids are judged. As with all testosterone injectables, testosterone cypionate is highly favored by athletes for its ability to promote strong increases in muscle mass and strength. It is interesting to note that while a large number of other steroidal compounds have been made available since testosterone injectables, they are still considered to be the dominant bulking agents among bodybuilders. There is little argument that these are among the most powerful mass drugs available, testosterone cypionate included.

2 - Testosterone cypionate and testosterone enanthate provide extremely comparable patterns of testosterone release. Not only are physical advantages not possible in one over the other, but actual differences in pharmacokinetic patterns are hard to notice (these two drugs are for all intents and purposes functionally interchangeable). The only key difference between the two seems to be around patient comfort. Cypionic acid is less irritating at the site of injection than enanthoic acid (enanthate) for a small percentage of patients. This makes testosterone cypionate a more favorable choice for those with recurring issues of injection-site pain with testosterone enanthate. This difference likely had something to do with the early development of this testosterone ester as a commercial drug product.

SIDE EFFECT:

1 - Testosterone is readily aromatized in the body to estradiol (estrogen). The aromatase (estrogen synthetase) enzyme is responsible for this metabolism of testosterone. Elevated estrogen levels can cause side effects such as increased water retention, body fat gain, and gynecomastia. Testosterone is considered a moderately estrogenic steroid. An anti-estrogen such as clomiphene citrate or tamoxifen citrate may be necessary to prevent estrogenic side effects. One may alternately use an aromatase inhibitor like Arimidex® (anastrozole), which more efficiently controls estrogen by preventing its synthesis. Aromatase inhibitors can be quite expensive in comparison to anti-estrogens, however, and may also have negative effects on blood lipids. Estrogenic side effects will occur in a dose-dependant manner, with higher doses (above normal therapeutic levels) of testosterone cypionate more likely to require the concurrent use of an anti-estrogen or aromatase inhibitor. Since water retention and loss of muscle definition are common with higher doses of testosterone cypionate, this drug is usually considered a poor choice for dieting or cutting phases of training. Its moderate estrogenicity makes it more ideal for bulking phases, where the added water retention will support raw strength and muscle size and help foster a stronger anabolic environment.

2 – Androgenic issue:

Testosterone is the primary male androgen, responsible for maintaining secondary male sexual characteristics. Elevated levels of testosterone are likely to produce androgenic side effects including oily skin, acne, and body/facial hair growth. Men with a genetic predisposition for hair loss (androgenetic alopecia) may notice accelerated male pattern balding. Those concerned about hair loss may find a more comfortable option in nandrolone decanoate, which is a comparably less androgenic steroid. Women are warned of the potential virilizing effects of anabolic/androgenic steroids, especially with a strong androgen such as testosterone. These may include deepening of the voice, menstrual irregularities, changes in skin texture, facial hair growth, and clitoral enlargement. In androgen-responsive target tissues such as the skin, scalp, and prostate, the high relative androgenicity of testosterone is dependant on its reduction to dihydrotestosterone (DHT). The 5-alpha reductase enzyme is responsible for this metabolism of testosterone. The concurrent use of a 5-alpha reductase inhibitor such as finasteride or dutasteride will interfere with site-specific potentiation of testosterone action, lowering the tendency of testosterone drugs to produce androgenic side effects. It is important to remember that anabolic and androgenic effects are both mediated via the cytosolic androgen receptor. Complete separation of testosterone’s anabolic and androgenic properties is not possible, even with total 5-alpha reductase inhibition.

3 – Hepatotoxicity issue:

Testosterone does not have hepatotoxic effects; liver toxicity is unlikely. One study examined the potential for hepatotoxicity with high doses of testosterone by administering 400 mg of the hormone per day (2,800 mg per week) to a group of male subjects. The steroid was taken orally so that higher peak concentrations would be reached in hepatic tissues compared to intramuscular injections. The hormone was given daily for 20 days, and produced no significant changes in liver enzyme values including serum albumin, bilirubin, alanine-amino-transferase, and alkaline phosphatases.

4 – Cardiovascular issue:

Anabolic/androgenic steroids can have deleterious effects on serum cholesterol. This includes a tendency to reduce HDL (good) cholesterol values and increase LDL (bad) cholesterol values, which may shift the HDL to LDL balance in a direction that favors greater risk of arteriosclerosis. The relative impact of an anabolic/androgenic steroid on serum lipids is dependant on the dose, route of administration (oral vs. injectable), type of steroid (aromatizable or nonaromatizable), and level of resistance to hepatic metabolism. Anabolic/androgenic steroids may also adversely affect blood pressure and triglycerides, reduce endothelial relaxation, and support left ventricular hypertrophy, all potentially increasing the risk of cardiovascular disease and myocardial infarction. Testosterone tends to have a much less dramatic impact on cardiovascular risk factors than synthetic steroids. This is due in part to its openness to metabolism by the liver, which allows it to have less effect on the hepatic management of cholesterol. The aromatization of testosterone to estradiol also helps to mitigate the negative effects of androgens on serum lipids. In one study, 280 mg per week of testosterone ester (enanthate) had a slight but not statistically significant effect on HDL cholesterol after 12 weeks, but when taken with an aromatase inhibitor a strong (25%) decrease was seen.452 Studies using 300 mg of testosterone ester (enanthate) per week for 20 weeks without an aromatase inhibitor demonstrated only a 13% decrease in HDL cholesterol, while at 600 mg the reduction reached 21%.453 The negative impact of aromatase inhibition should be taken into consideration before such drug is added to testosterone therapy. Due to the positive influence of estrogen on serum lipids, tamoxifen citrate or clomiphene citrate are preferred to aromatase inhibitors for those concerned with cardiovascular health, as they offer a partial estrogenic effect in the liver. This allows them to potentially improve lipid profiles and offset some of the negative effects of androgens. With doses of 600 mg or less per week, the impact on lipid profile tends to be noticeable but not dramatic, making an anti-estrogen (for cardioprotective purposes) perhaps unnecessary. Doses of 600 mg or less per week have also failed to produce statistically significant changes in LDL/VLDL cholesterol, triglycerides, apolipoprotein B/C-III, C-reactive protein, and insulin sensitivity, all indicating a relatively weak impact on cardiovascular risk factors.454 When used in moderate doses, injectable testosterone esters are usually considered to be the safest of all anabolic/androgenic steroids. To help reduce cardiovascular strain it is advised to maintain an active cardiovascular exercise program and minimize the intake of saturated fats, cholesterol, and simple carbohydrates at all times during active AAS administration. Supplementing with fish oils (4 grams per day) and a natural cholesterol/antioxidant formula such as Lipid Stabil or a product with comparable ingredients is also recommended.

5 - Testosterone Suppression issue:

All anabolic/androgenic steroids, when taken in doses sufficient to promote muscle gain are expected to suppress endogenous testosterone production. Testosterone is the primary male androgen and offers strong negative feedback on endogenous testosterone production. Testosterone-based drugs will, likewise, have a strong effect on the hypothalamic regulation of natural steroid hormones. Without the intervention of testosterone-stimulating substances, testosterone levels should return to normal within 1-4 months of drug secession. Note that prolonged hypogonadotrophic hypogonadism can develop secondary to steroid abuse, necessitating medical intervention. As with all anabolic/androgenic steroids, it is unlikely that one will retain every pound of new bodyweight after a cycle is concluded. This is especially true when withdrawing from a strong (aromatizing) androgen like testosterone cypionate, as much of the new weight gain is likely to be in the form of water retention, quickly eliminated after drug discontinuance. An imbalance of anabolic and catabolic hormones during the post-cycle recovery period may further create an environment that is unfavorable for the retention of muscle tissue. Proper ancillary drug therapy is usually recommended to help restore hormonal balance more quickly, ultimately helping the user retain more muscle tissue. Another way to lessen the post-cycle “crash” is to first replace testosterone cypionate with a milder anabolic such as nandrolone decanoate or methenolone enanthate. The new steroid would be administered alone for one to two more months, at a dosage of 200-400 mg per week. In this “stepping down” procedure the user is attempting to eliminate the watery bulk of a testosterone-based drug while simultaneously preserving the solid muscularity underneath. This practice can prove to be effective, even if mainly for psychological reasons (some may view it as simply dividing the crash into water and hormonal stages). Testosteronestimulating drugs are still typically used at the conclusion of therapy, as endogenous testosterone production will not rebound during the administration of nandrolone decanoate or methenolone enanthate.

Dose:

Male: 250 – 500 mg. per week.

To treat androgen insufficiency, the prescribing guidelines for testosterone cypionate call for a dosage of 50-400 mg every two to four weeks. Although active in the body for a longer time, testosterone cypionate is usually injected on a weekly basis for physique- or performance-enhancing purposes. The usual dosage is in the range of 200-600 mg per week, taken in cycles 6 to 12 weeks in length. This level is sufficient for most users to notice exceptional gains in muscle size and strength. Testosterone is usually incorporated into bulking phases of training, when added water retention will be of little consequence, the user more concerned with raw mass than definition. Some do incorporate the drug into cutting cycles as well, but typically in lower doses (100- 200 mg per week) and/or when accompanied by an aromatase inhibitor to keep estrogen levels under control. Testosterone cypionate is a very effective anabolic drug and is often used alone with great benefit. Some, however, find a need to stack it with other anabolic/androgenic steroids for a stronger effect, in which case an additional 200-400 mg per week of boldenone undecylenate, methenolone enanthate, or nandrolone decanoate should provide substantial results with no significant hepatotoxicity. Testosterone is ultimately very versatile and can be combined with many other anabolic/androgenic steroids to tailor the desired effect. While large doses are generally not advised, some bodybuilders have been known to use excessively high dosages of this drug (1,000 mg per week or more). This was much more common before the 1990’s, when cypionate vials were usually very cheap and easy to find. A “more is better” attitude is easy to justify when paying only $20 for a 10cc vial (today the typical price for a single injection). At dosages of 800-1000 mg per week or more, water retention will likely account for more of the additional weight gain than new muscle tissue. The practice of “megadosing” is inefficient (not to mention potentially dangerous), especially when we consider the typical high cost of steroids today.

Female: 250 mg. every two weeks.

Testosterone cypionate is rarely used with women in clinical medicine. When applied, it is most often used as a secondary medication during inoperable breast cancer, when other therapies have failed to produce a desirable effect and suppression of ovarian function is necessary. Testosterone cypionate is not recommended for women for physique- or performance-enhancing purposes due to its strong androgenic nature, tendency to produce virilizing side effects, and slowacting characteristics (making blood levels difficult to control).

Testosterone Cypionate

Alternative Names:

Testosterone Cipionate,Testosterone Cyclopenthylpropionate

Proprietary Names:

Andro-Cyp (100, 200 mg./ml),Depo-Testosterone (50, 100, 200 mg./ml),Depotest (100 mg., 200 mg./ml.),Duratest (100, 200 mg./ml.),Testa-C (200 mg./ml.),Testes Leo (100, 250 mg./2 ml.)

Description:

Testosterone Cypionate is an ester of testosterone with high anabolic and androgenic properties. It is oil based and therefore long acting. The common side-effects of Cypionate are mostly associated with its high androgenic component, testicular atrophy, reduced spermatogenesis and aromatization.

BENEFIT:

1 - Testosterone cypionate is a slow-acting injectable ester of the primary male androgen testosterone. Testosterone is also the principle anabolic hormone in men, and is the basis of comparison by which all other anabolic/androgenic steroids are judged. As with all testosterone injectables, testosterone cypionate is highly favored by athletes for its ability to promote strong increases in muscle mass and strength. It is interesting to note that while a large number of other steroidal compounds have been made available since testosterone injectables, they are still considered to be the dominant bulking agents among bodybuilders. There is little argument that these are among the most powerful mass drugs available, testosterone cypionate included.

2 - Testosterone cypionate and testosterone enanthate provide extremely comparable patterns of testosterone release. Not only are physical advantages not possible in one over the other, but actual differences in pharmacokinetic patterns are hard to notice (these two drugs are for all intents and purposes functionally interchangeable). The only key difference between the two seems to be around patient comfort. Cypionic acid is less irritating at the site of injection than enanthoic acid (enanthate) for a small percentage of patients. This makes testosterone cypionate a more favorable choice for those with recurring issues of injection-site pain with testosterone enanthate. This difference likely had something to do with the early development of this testosterone ester as a commercial drug product.

SIDE EFFECT:

1 - Testosterone is readily aromatized in the body to estradiol (estrogen). The aromatase (estrogen synthetase) enzyme is responsible for this metabolism of testosterone. Elevated estrogen levels can cause side effects such as increased water retention, body fat gain, and gynecomastia. Testosterone is considered a moderately estrogenic steroid. An anti-estrogen such as clomiphene citrate or tamoxifen citrate may be necessary to prevent estrogenic side effects. One may alternately use an aromatase inhibitor like Arimidex® (anastrozole), which more efficiently controls estrogen by preventing its synthesis. Aromatase inhibitors can be quite expensive in comparison to anti-estrogens, however, and may also have negative effects on blood lipids. Estrogenic side effects will occur in a dose-dependant manner, with higher doses (above normal therapeutic levels) of testosterone cypionate more likely to require the concurrent use of an anti-estrogen or aromatase inhibitor. Since water retention and loss of muscle definition are common with higher doses of testosterone cypionate, this drug is usually considered a poor choice for dieting or cutting phases of training. Its moderate estrogenicity makes it more ideal for bulking phases, where the added water retention will support raw strength and muscle size and help foster a stronger anabolic environment.

2 – Androgenic issue:

Testosterone is the primary male androgen, responsible for maintaining secondary male sexual characteristics. Elevated levels of testosterone are likely to produce androgenic side effects including oily skin, acne, and body/facial hair growth. Men with a genetic predisposition for hair loss (androgenetic alopecia) may notice accelerated male pattern balding. Those concerned about hair loss may find a more comfortable option in nandrolone decanoate, which is a comparably less androgenic steroid. Women are warned of the potential virilizing effects of anabolic/androgenic steroids, especially with a strong androgen such as testosterone. These may include deepening of the voice, menstrual irregularities, changes in skin texture, facial hair growth, and clitoral enlargement. In androgen-responsive target tissues such as the skin, scalp, and prostate, the high relative androgenicity of testosterone is dependant on its reduction to dihydrotestosterone (DHT). The 5-alpha reductase enzyme is responsible for this metabolism of testosterone. The concurrent use of a 5-alpha reductase inhibitor such as finasteride or dutasteride will interfere with site-specific potentiation of testosterone action, lowering the tendency of testosterone drugs to produce androgenic side effects. It is important to remember that anabolic and androgenic effects are both mediated via the cytosolic androgen receptor. Complete separation of testosterone’s anabolic and androgenic properties is not possible, even with total 5-alpha reductase inhibition.

3 – Hepatotoxicity issue:

Testosterone does not have hepatotoxic effects; liver toxicity is unlikely. One study examined the potential for hepatotoxicity with high doses of testosterone by administering 400 mg of the hormone per day (2,800 mg per week) to a group of male subjects. The steroid was taken orally so that higher peak concentrations would be reached in hepatic tissues compared to intramuscular injections. The hormone was given daily for 20 days, and produced no significant changes in liver enzyme values including serum albumin, bilirubin, alanine-amino-transferase, and alkaline phosphatases.

4 – Cardiovascular issue:

Anabolic/androgenic steroids can have deleterious effects on serum cholesterol. This includes a tendency to reduce HDL (good) cholesterol values and increase LDL (bad) cholesterol values, which may shift the HDL to LDL balance in a direction that favors greater risk of arteriosclerosis. The relative impact of an anabolic/androgenic steroid on serum lipids is dependant on the dose, route of administration (oral vs. injectable), type of steroid (aromatizable or nonaromatizable), and level of resistance to hepatic metabolism. Anabolic/androgenic steroids may also adversely affect blood pressure and triglycerides, reduce endothelial relaxation, and support left ventricular hypertrophy, all potentially increasing the risk of cardiovascular disease and myocardial infarction. Testosterone tends to have a much less dramatic impact on cardiovascular risk factors than synthetic steroids. This is due in part to its openness to metabolism by the liver, which allows it to have less effect on the hepatic management of cholesterol. The aromatization of testosterone to estradiol also helps to mitigate the negative effects of androgens on serum lipids. In one study, 280 mg per week of testosterone ester (enanthate) had a slight but not statistically significant effect on HDL cholesterol after 12 weeks, but when taken with an aromatase inhibitor a strong (25%) decrease was seen.452 Studies using 300 mg of testosterone ester (enanthate) per week for 20 weeks without an aromatase inhibitor demonstrated only a 13% decrease in HDL cholesterol, while at 600 mg the reduction reached 21%.453 The negative impact of aromatase inhibition should be taken into consideration before such drug is added to testosterone therapy. Due to the positive influence of estrogen on serum lipids, tamoxifen citrate or clomiphene citrate are preferred to aromatase inhibitors for those concerned with cardiovascular health, as they offer a partial estrogenic effect in the liver. This allows them to potentially improve lipid profiles and offset some of the negative effects of androgens. With doses of 600 mg or less per week, the impact on lipid profile tends to be noticeable but not dramatic, making an anti-estrogen (for cardioprotective purposes) perhaps unnecessary. Doses of 600 mg or less per week have also failed to produce statistically significant changes in LDL/VLDL cholesterol, triglycerides, apolipoprotein B/C-III, C-reactive protein, and insulin sensitivity, all indicating a relatively weak impact on cardiovascular risk factors.454 When used in moderate doses, injectable testosterone esters are usually considered to be the safest of all anabolic/androgenic steroids. To help reduce cardiovascular strain it is advised to maintain an active cardiovascular exercise program and minimize the intake of saturated fats, cholesterol, and simple carbohydrates at all times during active AAS administration. Supplementing with fish oils (4 grams per day) and a natural cholesterol/antioxidant formula such as Lipid Stabil or a product with comparable ingredients is also recommended.

5 - Testosterone Suppression issue:

All anabolic/androgenic steroids, when taken in doses sufficient to promote muscle gain are expected to suppress endogenous testosterone production. Testosterone is the primary male androgen and offers strong negative feedback on endogenous testosterone production. Testosterone-based drugs will, likewise, have a strong effect on the hypothalamic regulation of natural steroid hormones. Without the intervention of testosterone-stimulating substances, testosterone levels should return to normal within 1-4 months of drug secession. Note that prolonged hypogonadotrophic hypogonadism can develop secondary to steroid abuse, necessitating medical intervention. As with all anabolic/androgenic steroids, it is unlikely that one will retain every pound of new bodyweight after a cycle is concluded. This is especially true when withdrawing from a strong (aromatizing) androgen like testosterone cypionate, as much of the new weight gain is likely to be in the form of water retention, quickly eliminated after drug discontinuance. An imbalance of anabolic and catabolic hormones during the post-cycle recovery period may further create an environment that is unfavorable for the retention of muscle tissue. Proper ancillary drug therapy is usually recommended to help restore hormonal balance more quickly, ultimately helping the user retain more muscle tissue. Another way to lessen the post-cycle “crash” is to first replace testosterone cypionate with a milder anabolic such as nandrolone decanoate or methenolone enanthate. The new steroid would be administered alone for one to two more months, at a dosage of 200-400 mg per week. In this “stepping down” procedure the user is attempting to eliminate the watery bulk of a testosterone-based drug while simultaneously preserving the solid muscularity underneath. This practice can prove to be effective, even if mainly for psychological reasons (some may view it as simply dividing the crash into water and hormonal stages). Testosteronestimulating drugs are still typically used at the conclusion of therapy, as endogenous testosterone production will not rebound during the administration of nandrolone decanoate or methenolone enanthate.

Dose:

Male: 250 – 500 mg. per week.

To treat androgen insufficiency, the prescribing guidelines for testosterone cypionate call for a dosage of 50-400 mg every two to four weeks. Although active in the body for a longer time, testosterone cypionate is usually injected on a weekly basis for physique- or performance-enhancing purposes. The usual dosage is in the range of 200-600 mg per week, taken in cycles 6 to 12 weeks in length. This level is sufficient for most users to notice exceptional gains in muscle size and strength. Testosterone is usually incorporated into bulking phases of training, when added water retention will be of little consequence, the user more concerned with raw mass than definition. Some do incorporate the drug into cutting cycles as well, but typically in lower doses (100- 200 mg per week) and/or when accompanied by an aromatase inhibitor to keep estrogen levels under control. Testosterone cypionate is a very effective anabolic drug and is often used alone with great benefit. Some, however, find a need to stack it with other anabolic/androgenic steroids for a stronger effect, in which case an additional 200-400 mg per week of boldenone undecylenate, methenolone enanthate, or nandrolone decanoate should provide substantial results with no significant hepatotoxicity. Testosterone is ultimately very versatile and can be combined with many other anabolic/androgenic steroids to tailor the desired effect. While large doses are generally not advised, some bodybuilders have been known to use excessively high dosages of this drug (1,000 mg per week or more). This was much more common before the 1990’s, when cypionate vials were usually very cheap and easy to find. A “more is better” attitude is easy to justify when paying only $20 for a 10cc vial (today the typical price for a single injection). At dosages of 800-1000 mg per week or more, water retention will likely account for more of the additional weight gain than new muscle tissue. The practice of “megadosing” is inefficient (not to mention potentially dangerous), especially when we consider the typical high cost of steroids today.

Female: 250 mg. every two weeks.

Testosterone cypionate is rarely used with women in clinical medicine. When applied, it is most often used as a secondary medication during inoperable breast cancer, when other therapies have failed to produce a desirable effect and suppression of ovarian function is necessary. Testosterone cypionate is not recommended for women for physique- or performance-enhancing purposes due to its strong androgenic nature, tendency to produce virilizing side effects, and slowacting characteristics (making blood levels difficult to control).

Sustanon is a brand name for a specific formulation of testosterone replacement therapy medication. It is a combination of four different testosterone esters:

1. Testosterone propionate
2. Testosterone phenylpropionate
3. Testosterone isocaproate
4. Testosterone decanoate

Each of these esters has a different release rate and duration of action in the body, which allows for a more sustained release of testosterone over time.

Sustanon is primarily used in hormone replacement therapy for men with hypogonadism, a condition characterized by low levels of testosterone in the body. It is also used in some cases to treat delayed puberty or conditions where testosterone production is impaired.

Due to its composition, Sustanon typically requires less frequent dosing compared to single ester formulations of testosterone. It is typically administered via intramuscular injection and may need to be given every 2-4 weeks, depending on the specific dosage and individual response.

Sustanon helps restore testosterone levels in men with hypogonadism, leading to improvements in symptoms such as low libido, erectile dysfunction, fatigue, and reduced muscle mass and strength. It may also have benefits for bone density and overall well-being.

As with any medication, Sustanon may cause side effects, including but not limited to acne, oily skin, fluid retention, increased red blood cell count, and mood changes. It may also have more severe risks, such as cardiovascular complications and prostate enlargement, especially in individuals with pre-existing conditions.

Sustanon is available by prescription and should only be used under the supervision of a healthcare professional experienced in hormone replacement therapy. It is not recommended for use in women and children. Additionally, its use is regulated in many countries due to its potential for abuse, and it is classified as a controlled substance.

Sustanon is a brand name for a specific formulation of testosterone replacement therapy medication. It is a combination of four different testosterone esters:

1. Testosterone propionate
2. Testosterone phenylpropionate
3. Testosterone isocaproate
4. Testosterone decanoate

Each of these esters has a different release rate and duration of action in the body, which allows for a more sustained release of testosterone over time.

Sustanon is primarily used in hormone replacement therapy for men with hypogonadism, a condition characterized by low levels of testosterone in the body. It is also used in some cases to treat delayed puberty or conditions where testosterone production is impaired.

Due to its composition, Sustanon typically requires less frequent dosing compared to single ester formulations of testosterone. It is typically administered via intramuscular injection and may need to be given every 2-4 weeks, depending on the specific dosage and individual response.

Sustanon helps restore testosterone levels in men with hypogonadism, leading to improvements in symptoms such as low libido, erectile dysfunction, fatigue, and reduced muscle mass and strength. It may also have benefits for bone density and overall well-being.

As with any medication, Sustanon may cause side effects, including but not limited to acne, oily skin, fluid retention, increased red blood cell count, and mood changes. It may also have more severe risks, such as cardiovascular complications and prostate enlargement, especially in individuals with pre-existing conditions.

Sustanon is available by prescription and should only be used under the supervision of a healthcare professional experienced in hormone replacement therapy. It is not recommended for use in women and children. Additionally, its use is regulated in many countries due to its potential for abuse, and it is classified as a controlled substance.

Sustanon is a brand name for a specific formulation of testosterone replacement therapy medication. It is a combination of four different testosterone esters:

1. Testosterone propionate
2. Testosterone phenylpropionate
3. Testosterone isocaproate
4. Testosterone decanoate

Each of these esters has a different release rate and duration of action in the body, which allows for a more sustained release of testosterone over time.

Sustanon is primarily used in hormone replacement therapy for men with hypogonadism, a condition characterized by low levels of testosterone in the body. It is also used in some cases to treat delayed puberty or conditions where testosterone production is impaired.

Due to its composition, Sustanon typically requires less frequent dosing compared to single ester formulations of testosterone. It is typically administered via intramuscular injection and may need to be given every 2-4 weeks, depending on the specific dosage and individual response.

Sustanon helps restore testosterone levels in men with hypogonadism, leading to improvements in symptoms such as low libido, erectile dysfunction, fatigue, and reduced muscle mass and strength. It may also have benefits for bone density and overall well-being.

As with any medication, Sustanon may cause side effects, including but not limited to acne, oily skin, fluid retention, increased red blood cell count, and mood changes. It may also have more severe risks, such as cardiovascular complications and prostate enlargement, especially in individuals with pre-existing conditions.

Sustanon is available by prescription and should only be used under the supervision of a healthcare professional experienced in hormone replacement therapy. It is not recommended for use in women and children. Additionally, its use is regulated in many countries due to its potential for abuse, and it is classified as a controlled substance.

Trenbolone Enanthate

Description:

Trenbolone enanthate is an injectable form of the strong anabolic steroid trenbolone. Given the use of an enanthate ester, this drug will exhibit virtually identical pharmacokinetics to testosterone enanthate, providing a peak release of its steroid within the first several days after injection, followed by declining levels for approximately 2 weeks. The base steroid here (trenbolone) is a derivative of nandrolone, and exhibits strong anabolic and androgenic properties. On a milligram for milligram basis it is considerably more potent than testosterone as both an anabolic and androgenic agent, though it does carry a more favorable balance (toward anabolism). Trenbolone is also unable to convert to estrogen, however it does exhibit notable progestational activity, which may mimic estrogenic side effects given the right physiological conditions. Trenbolone enanthate is virtually interchangeable with Parabolan (trenbolone hexahydrobenzylcarbonate), capable of promoting strong gains in lean muscle mass, often with an accompanying increase in relative hardness and definition.

History:

Slow-acting trenbolone esters were first studied in 1967, during a series of experiments into synthetic anabolic steroids by Roussel-UCLAF. 607 Roussel did not specifically investigate Trenbolone enanthate, although the drug would have remained an obvious possibility once trenbolone was released given the widespread application of steroid esters (including enanthate) by the 1960’s. The drug would not see the light of day for many decades, however, and was only first released for commercial sale in 2004. It was introduced by British Dragon, an underground manufacturer. British Dragon would sell it under the trade name Trenabol, in 200 mg/mL strength. Although it was not for sale through pharmacies nor approved for human or veterinary use, Trenabol was widely distributed throughout the world, and became an extremely popular product with athletes and bodybuilders. Much of this had to do with the fact that it was unique, in that it was one of but a few options for injectable trenbolone that used slowacting esters. At the time of its introduction, trenbolone acetate products were by and large the dominant form of trenbolone, and remain the dominant form of the drug to this day. Although British Dragon was perhaps the largest and most well known underground steroid manufacturer in the world, the company abruptly collapsed at the end of 2006. The brand has since re-emerged under new ownership. Trenbolone enanthate continues to be sold by a number of underground labs, though no registered drug company has yet introduced it to a legitimate drug market.

Structural Characteristics:

Trenbolone is a modified form of nandrolone. It differs by the introduction of double bonds at carbons 9 and 11, which inhibit aromatization (9-ene), increase androgen-binding affinity,608 and slows its metabolism. The resulting steroid is significantly more potent as both an anabolic and an androgen than its nandrolone base. The trenbolone here is modified with an enanthate ester at the 17-beta hydroxyl group, so that the free steroid is released more slowly from the area of injection.

CONS:

1 - Side Effects (Estrogenic):

Trenbolone is not aromatized by the body, and is not measurably estrogenic. It is of note, however, that this steroid displays significant binding affinity for the progesterone receptor (slightly stronger than progesterone itself ).609 610 The side effects associated with progesterone are similar to those of estrogen, including negative feedback inhibition of testosterone production and enhanced rate of fat storage. Progestins also augment the stimulatory effect of estrogens on mammary tissue growth. There appears to be a strong synergy between these two hormones, such that gynecomastia might even occur with the help of progestins, without excessive estrogen levels. The use of an antiestrogen, which inhibits the estrogenic component of this disorder, is often sufficient to mitigate gynecomastia caused by progestational anabolic/androgenic steroids. Note that progestational side effects are more common when trenbolone is being taken with other aromatizable steroids.

2 - Side Effects (Androgenic):

Although classified as an anabolic steroid, trenbolone is sufficiently androgenic. Androgenic side effects are still common with this substance, and may include bouts of oily skin, acne, and body/facial hair growth. Anabolic/androgenic steroids may also aggravate male pattern hair loss. Women are also warned of the potential virilizing effects of anabolic/androgenic steroids. These may include a deepening of the voice, menstrual irregularities, changes in skin texture, facial hair growth, and clitoral enlargement. Additionally, the 5-alpha reductase enzyme does not metabolize trenbolone,611 so its relative androgenicity is not affected by finasteride or dutasteride.

3 - Side Effects (Hepatotoxicity):

Trenbolone is not c-17 alpha alkylated, and is generally not considered a hepatotoxic steroid; liver toxicity is unlikely. This steroid does have a strong level of resistance to hepatic breakdown, however, and severe liver toxicity has been noted in bodybuilders abusing trenbolone.612 Although unlikely, hepatotoxicity cannot be completely excluded, especially with high doses.

4 - Side Effects (Cardiovascular):

Anabolic/androgenic steroids can have deleterious effects on serum cholesterol. This includes a tendency to reduce HDL (good) cholesterol values and increase LDL (bad) cholesterol values, which may shift the HDL to LDL balance in a direction that favors greater risk of arteriosclerosis. The relative impact of an anabolic/androgenic steroid on serum lipids is dependant on the dose, route of administration (oral vs. injectable), type of steroid (aromatizable or nonaromatizable), and level of resistance to hepatic metabolism. Due to its non-aromatizable nature and strong resistance to metabolism, trenbolone has a moderate to strong (negative) impact on lipid values and atherogenic risk. Anabolic/androgenic steroids may also adversely affect blood pressure and triglycerides, reduce endothelial relaxation, and support left ventricular hypertrophy, all potentially increasing the risk of cardiovascular disease and myocardial infarction. To help reduce cardiovascular strain it is advised to maintain an active cardiovascular exercise program and minimize the intake of saturated fats, cholesterol, and simple carbohydrates at all times during active AAS administration. Supplementing with fish oils (4 grams per day) and a natural cholesterol/antioxidant formula such as Lipid Stabil or a product with comparable ingredients is also recommended.

5 - Side Effects (Testosterone Suppression):

All anabolic/androgenic steroids when taken in doses sufficient to promote muscle gain are expected to suppress endogenous testosterone production. Without the intervention of testosterone-stimulating substances, testosterone levels should return to normal within 1-4 months of drug secession. Note that prolonged hypogonadotrophic hypogonadism can develop secondary to steroid abuse, necessitating medical intervention. In experimental studies, trenbolone was determined to be approximately three times stronger at suppressing gonadotropins than testosterone on a milligram for milligram basis.

Administration (Men):

Trenbolone enanthate was never approved for use in humans. Prescribing guidelines are unavailable. Common doses for physique- and performance-enhancing purposes fall in the range of 150-300 mg per week, which is usually taken for 6- 10 consecutive weeks. This level is sufficient to produce considerable increases in lean muscle mass and strength, which are usually combined with notable fat loss and increased muscle definition. As with all trenbolone injectables, this product is fairly versatile, and can be combined with many other agents depending on the desired results.

Administration (Women):

Trenbolone enanthate was never approved for use in humans. Prescribing guidelines are unavailable.This agent is generally not recommended for women for physique- or performance-enhancing purposes due to strong androgenic nature and tendency to produce virilizing side effects.

Trenbolone Enanthate Cycle:

Trenbolone enanthate is a synthetic anabolic steroid that is derived from nandrolone. It is commonly used by bodybuilders and athletes to enhance muscle growth, strength, and performance. Trenbolone enanthate has a long-lasting ester attached to it, which means it stays active in the body for an extended period, requiring less frequent injections compared to other forms of trenbolone.

A typical trenbolone enanthate cycle can vary depending on individual goals, experience level, and tolerance to the compound. However, a common cycle duration ranges from 8 to 12 weeks. Here is a general example of a trenbolone enanthate cycle:

Week 1-12:

• Trenbolone enanthate: 200-400 mg per week (this dosage range can vary depending on individual tolerance and experience level)

In addition to trenbolone enanthate, individuals may stack it with other anabolic steroids or compounds to enhance results. Some common compounds used in trenbolone cycles include testosterone (to maintain normal physiological functions), an aromatase inhibitor (to control estrogen levels), and compounds for liver support.

Post-cycle therapy (PCT) is essential after completing a trenbolone cycle to help restore natural hormone production and minimize potential side effects. PCT usually includes medications such as selective estrogen receptor modulators (SERMs) like tamoxifen or aromatase inhibitors (AIs) to regulate estrogen levels and stimulate the production of testosterone.

It's crucial to remember that the use of trenbolone and other anabolic steroids carries risks, including potential side effects such as cardiovascular issues, liver toxicity, suppression of natural hormone production, and others. Therefore, it's essential to use these substances responsibly, under the supervision of a qualified healthcare professional, and to prioritize overall health and safety. Additionally, it's important to adhere to legal regulations regarding the use of anabolic steroids in your country or region.

Trenbolone Hexahydrobenzylcarbonate

Description:

Trenbolone hexahydrobenzylcarbonate is a slow-acting injectable ester of the potent anabolic steroid trenbolone. Trenbolone appears most commonly as trenbolone acetate, which is a much faster-acting form of the drug (see: Finajet). The hexahydrobenzylcarbonate ester used here extends the release of trenbolone for more than 2 weeks, which has always been thought of as more suitable for human use due to the less frequent injection schedule. The base steroid trenbolone is roughly three times more androgenic than testosterone, making it a fairly potent androgen. It also displays about 3 times greater tissue-building activity in comparison to its androgenic properties, making its official classification as that of an anabolic steroid. The musclebuilding effect of trenbolone is often compared to such popular bulking agents as testosterone or Dianabol, but without the same estrogenrelated side effects. It is most commonly identified as a lean-mass-building drug and is extremely popular with athletes for its ability to promote the rapid buildup of strength, muscle size, and definition.

History:

The first long-acting trenbolone ester (undecanoate) was studied in 1967, described during a series of experiments into synthetic anabolic steroids by Roussel-UCLAF. 571 Trenbolone hexahydrobenzylcarbonate was a subsequent and uniquely French slant to this long-acting anabolic steroid, possessing an unusual but roughly equivalent compound. Trenbolone hexahydrobenzylcarbonate was developed into a medicine by Negma Laboratoires in France, which sold the drug under the Parabolan trade name. It was also sold for a period of time as Hexabolan, a name that referred to the unusual ester it possesses. Trenbolone hexahydrobenzylcarbonate is the only known form of trenbolone ever produced as a medicine for human consumption. The most notable appearance of trenbolone comes as trenbolone acetate, which is used widely and exclusively in veterinary medicine. Parabolan was prescribed in France as a protein-sparing anabolic agent in cases of cachexia (lean body mass wasting) and malnutrition, as well as to combat certain forms of osteoporosis. Its prescribing guidelines included recommendations for the treatment of androgen-sensitive populations, such as women and the elderly. Owing to its moderate androgenic properties, however, the drug was contraindicated in children, especially young females. Parabolan remained on the French market for a very long time, although it was finally discontinued (voluntarily) by Negma in 1997. For a brief period, it seemed that the demise of Parabolan would mark the end of human-use trenbolone preparations, as no other medicine approved for human use was known to exist worldwide at the time. A very small number of Parabolan preparations have been brought to market since, however, so while the drug is still poorly available, it is not completely defunct.

Structural Characteristics:

Trenbolone is a modified form of nandrolone. It differs by the introduction of double bonds at carbons 9 and 11, which inhibit aromatization (9-ene), increase androgen-binding affinity, and slows its metabolism. The resulting steroid is significantly more potent as both an anabolic and an androgen than its nandrolone base. The trenbolone here is modified with a hexahydrobenzylcarbonate ester at the 17- beta hydroxyl group, so that the free steroid is released more slowly from the area of injection.

Trenbolone Hexahydrobenzylcarbonate Side Effects:

1 - Side Effects (Estrogenic):

Trenbolone is not aromatized by the body and is not measurably estrogenic. It is of note, however, that this steroid displays significant binding affinity for the progesterone receptor (slightly stronger than progesterone itself). The side effects associated with progesterone are like those of estrogen, including negative feedback inhibition of testosterone production and enhanced rate of fat storage. Progestins also augment the stimulatory effect of estrogens on mammary tissue growth. There appears to be a strong synergy between these two hormones here, such that gynecomastia might even occur with the help of progestins, without excessive estrogen levels. The use of an antiestrogen, which inhibits the estrogenic component of this disorder, is often sufficient to mitigate gynecomastia caused by progestational anabolic/androgenic steroids. Note that progestational side effects are more common when trenbolone is being taken with other aromatizable steroids.

2 - Side Effects (Androgenic):

Although classified as an anabolic steroid, trenbolone is sufficiently androgenic. Androgenic side effects are still common with this substance, and may include bouts of oily skin, acne, and body/facial hair growth. Anabolic/androgenic steroids may also aggravate male pattern hair loss. Women are also warned of the potential virilizing effects of anabolic/androgenic steroids. These may include a deepening of the voice, menstrual irregularities, changes in skin texture, facial hair growth, and clitoral enlargement. Additionally, the 5-alpha reductase enzyme does not metabolize trenbolone, so its relative androgenicity is not affected by finasteride or dutasteride.

3 - Side Effects (Hepatotoxicity):

Trenbolone is not c-17 alpha alkylated, and is generally not considered a hepatotoxic steroid; liver toxicity is unlikely. This steroid does have a strong level of resistance to hepatic breakdown, however, and severe liver toxicity has been noted in bodybuilders abusing trenbolone.576 Although unlikely, hepatotoxicity cannot be completely excluded, especially with high doses.

4 - Side Effects (Cardiovascular):

Anabolic/androgenic steroids can have deleterious effects on serum cholesterol. This includes a tendency to reduce HDL (good) cholesterol values and increase LDL (bad) cholesterol values, which may shift the HDL to LDL balance in a direction that favors greater risk of arteriosclerosis. The relative impact of an anabolic/androgenic steroid on serum lipids is dependant on the dose, route of administration (oral vs. injectable), type of steroid (aromatizable or nonaromatizable), and level of resistance to hepatic metabolism. Due to its non-aromatizable nature and strong resistance to metabolism, trenbolone has a moderate to strong (negative) impact on lipid values and atherogenic risk. Anabolic/androgenic steroids may also adversely affect blood pressure and triglycerides, reduce endothelial relaxation, and support left ventricular hypertrophy, all potentially increasing the risk of cardiovascular disease and myocardial infarction. To help reduce cardiovascular strain it is advised to maintain an active cardiovascular exercise program and minimize the intake of saturated fats, cholesterol, and simple carbohydrates at all times during active AAS administration. Supplementing with fish oils (4 grams per day) and a natural cholesterol/antioxidant formula such as Lipid Stabil or a product with comparable ingredients is also recommended.

5 - Side Effects (Testosterone Suppression):

All anabolic/androgenic steroids when taken in doses sufficient to promote muscle gain are expected to suppress endogenous testosterone production. Without the intervention of testosterone-stimulating substances, testosterone levels should return to normal within 1-4 months of drug secession. Note that prolonged hypogonadotrophic hypogonadism can develop secondary to steroid abuse, necessitating medical intervention. In experimental studies, trenbolone was determined to be approximately three times stronger at suppressing gonadotropins than testosterone on a milligram for milligram basis.

Trenbolone Hexahydrobenzylcarbonate Dose:

Male:

Trenbolone hexahydrobenzylcarbonate was generally administered in a clinical dosage of 3 ampules per month. Therapy was initiated the first month with all 3 ampules given over the first 15 days. During the subsequent 3 months, one injection (76 mg) was given every 10 days. For physique- or performance-enhancing purposes, trenbolone hexahydrobenzylcarbonate is most often administered at a dosage of 152-220 mg per week. The drug would be taken in cycles ranging from 6 to 12 weeks. Although a weekly administration schedule would be more than sufficient, athletes usually injected a single ampule (76mg) at a time, and the total amount would be spread evenly throughout the week. Although not necessary, this type of schedule helps to reduce injection volume per application. The results with the use of trenbolone hexahydrobenzylcarbonate should be a visibly more muscular physique (larger, leaner), and, if body fat levels are low enough, that hard ripped look most valued by dieting and competitive bodybuilders. While this drug is quite potent when used alone, it is sometimes combined with other steroids for an even greater effect. Leading up to a show one could successfully add a non-aromatizing anabolic such as Winstrol® or Primobolan®. Such combinations will elicit a greater level of density and hardness to the build, often proving dramatic for a stage appearance. We could also look for bulk with this drug, and addition stronger compounds like Dianabol or Testosterone. While the mass gain would be quite formidable with such a stack, some level of water retention would probably also accompany it. Moderately effective anabolics such Deca-Durabolin® or Equipoise® would be somewhat of a halfway point, providing extra strength and mass but without the same level of water bloat we see with more readily aromatized steroids.

Female:

Trenbolone hexahydrobenzylcarbonate was generally administered in a clinical dosage of 3 ampules per month. Therapy was initiated the first month with all 3 ampules given over the first 15 days. During the subsequent 3 months, one injection (76mg) was given every 10 days. Given the risk of virilization, lower doses were likely used by physicians with many female patients. This agent is generally not recommended for women for physique- or performanceenhancing purposes due to strong androgenic nature and tendency to produce virilizing side effects.

Trenbolone Hexahydrobenzylcarbonate Cycle:

often referred to as Parabolan, is a longer-acting esterified form of trenbolone, an anabolic steroid. It's commonly used by bodybuilders and athletes to enhance muscle growth, strength, and overall performance.

A typical Trenbolone hexahydrobenzylcarbonate cycle, like other trenbolone cycles, can vary depending on individual goals, experience level, and tolerance to the compound. Here's an example of a Trenbolone hexahydrobenzylcarbonate cycle:

Week 1-12:

• Trenbolone hexahydrobenzylcarbonate: 200-400 mg per week

Some individuals may choose to stack Trenbolone hexahydrobenzylcarbonate with other anabolic steroids or compounds to enhance results. Common compounds used in Trenbolone cycles include testosterone (to maintain normal physiological functions), an aromatase inhibitor (to control estrogen levels), and compounds for liver support.

Trenbolone Hexahydrobenzylcarbonate Post-cycle therapy (PCT)

is crucial after completing a Trenbolone hexahydrobenzylcarbonate cycle to help restore natural hormone production and minimize potential side effects. PCT usually includes medications such as selective estrogen receptor modulators (SERMs) like tamoxifen or aromatase inhibitors (AIs) to regulate estrogen levels and stimulate the production of testosterone.

It's important to note that Trenbolone, including Trenbolone hexahydrobenzylcarbonate, is a potent steroid that carries risks, including potential side effects such as cardiovascular issues, liver toxicity, suppression of natural hormone production, and others. Therefore, it's essential to use these substances responsibly, under the supervision of a qualified healthcare professional, and to prioritize overall health and safety. Additionally, it's crucial to adhere to legal regulations regarding the use of anabolic steroids in your country or region

Tamsulosin

Benefit:

Tamsulosin is a medication primarily used to treat benign prostatic hyperplasia (BPH), also known as prostate enlargement. It belongs to a class of medications called alpha-1 blockers or alpha-adrenergic blockers.

Tamsulosin works by relaxing the smooth muscles in the prostate gland and the bladder neck, which helps to relieve symptoms associated with BPH. These symptoms may include difficulty urinating, weak urine flow, urinary urgency, frequent urination, and nocturia (waking up at night to urinate).

By blocking alpha-1 adrenergic receptors in the smooth muscle tissue of the prostate gland and bladder neck, tamsulosin helps to improve the flow of urine and reduce symptoms related to BPH. It does not shrink the size of the prostate gland but rather improves urinary function and quality of life for individuals with BPH.

Tamsulosin is typically taken orally in the form of capsules or tablets. It is usually taken once daily, either with or without food. The dosage may vary depending on the individual's response to the medication and their specific medical condition.

Side Effect:

Common side effects of tamsulosin may include dizziness, lightheadedness, headache, nasal congestion, and abnormal ejaculation (in men). These side effects are usually mild and temporary but may be more pronounced when starting treatment or increasing the dose.

Tamsulosin is generally considered safe and effective for most people when used as directed. However, it may not be suitable for everyone, especially those with certain medical conditions or who are taking certain medications. It's important to discuss the potential risks and benefits of tamsulosin with a healthcare professional before starting treatment

Stanozolol Inject.

Alternative Names:

Androstanazole,Methylstanazole.

Proprietary Names:

Stromba (50 mg./ml.),Stromaject (50 mg./ml.), Winstrol Depot (50 mg./ml.)

Veterinary:

Winstrol V (50 mg./ml.)

Description:

Winstrol is the most widely recognized trade name for the drug stanozolol. Stanozolol is a derivative of dihydrotestosterone, chemically altered so that the hormone’s anabolic (tissue-building) properties are greatly amplified and its androgenic activity minimized. Stanozolol is classified as an “anabolic” steroid, and exhibits one of the strongest dissociations of anabolic to androgenic effect among commercially available agents. It also cannot be aromatized into estrogens. Stanozolol is the second most widely used oral steroid, succeeded in popularity only by Dianabol (methandrostenolone). It is favored for its ability to promote muscle growth without water-retention, making it highly valued by dieting bodybuilders and competitive athletes.

History:

Stanozolol was first described in 1959. It was developed into a medicine by Winthrop Laboratories in Great Britain. Parent firm (Sterling) filed for U.S. patent on the agent in 1961.614 Stanozolol was officially released to the U.S. prescription drug market in 1962 under the brand name Winstrol. Stanozolol was initially prescribed for a variety of medical purposes, including the induction of appetite and lean tissue gain in cases of weight loss associated with many malignant and non-malignant diseases, the preservation of bone mass during osteoporosis, the promotion of liner growth in children with growth failure, as an anti-catabolic during prolonged corticosteroid therapy or for post-operative and post-trauma (burns, fractures) patients, and even to treat debility in the elderly. The FDA’s control over the prescription drug market had tightened by the mid-1970’s, and the indicated uses for Winstrol were soon narrowed. During this time the FDA officially supported that Winstrol was “Probably Effective” as an adjunct therapy for treating osteoporosis, and for promoting growth in pituitary-deficient dwarfism. With this position, Winthrop was given more time to sell and study the agent. Winthrop was able to continually satisfy the FDA regarding Winstrol’s validity as a therapeutic agent, and it remained in the U.S. throughout the 1980’s and 1990’s, a time when many other anabolic steroids were disappearing from the marketplace. Stanozolol was also showing some promise during this period for improving red blood cell concentrations, combating breast cancer, and (more recently) treating angioedema, a disorder characterized by the swelling of subdermal tissues, often with hereditary causes. Winthrop went through a number of corporate changes during the 1990’s, including a 1991 merger with Elf Sanofi to form Sanofi Winthrop. Sanofi Winthrop continued on to sell Winstrol in the U.S. for approximately 10 more years, before finally discontinuing the medication because of “manufacturing issues” (Searle was actually making the product for Sanofi at the time, and had reportedly ceased production). In 2003, the rights to Winstrol were officially transferred to Ovation Pharmaceuticals. Winstrol remains an approved drug on the U.S. pharmaceutical market, although is not under active production by Ovation label. All forms of Winstrol are presently unavailable in the U.S., although the Winstrol brand remains available in Spain. Numerous other brands and generic forms of the drug are produced in other countries, in both human and veterinary drug markets.

Structural Characteristics:

Stanozolol is a modified form of dihydrotestosterone. It differs by: 1) the addition of a methyl group at carbon 17- alpha to protect the hormone during oral administration and 2) the attachment of a pyrazol group to the A-ring, replacing the normal 3-keto group (this gives stanozolol the chemical classification of a heterocyclic steroid). When viewed in the light of 17-alpha methyldihydrotestosterone, the A-ring modification on stanozolol seems to considerably increase its anabolic strength while reducing its relative androgenicity. Stanozolol has a much weaker relative binding affinity for the androgen receptor than testosterone or dihydrotestosterone. At the same time it displays a much longer half-life and lower affinity for serum binding proteins in comparison. These features (among others) allow stanozolol to be a very potent anabolic steroid in spite of a weaker affinity for receptor binding. Recent studies have additionally confirmed that its primary mode if action involves interaction with the cellular androgen receptor.615 Although not fully elucidated, stanozolol may have additional (some potentially unique) properties with regard to antagonism of the progesterone receptor, Low Affinity Glucocorticoid-binding Site interaction, and AR/PR/GR independent activities. In therapeutic doses stanozolol does not have significant progestational activity.619 Stanozolol is known to strongly suppress levels of SHBG (sex hormone-binding globulin). This trait is characteristic of all anabolic/androgenic steroids, although its potency and form of administration make oral Winstrol® particularly effective in this regard. One study with a group of 25 normal males demonstrated a 48.4% reduction in SHBG after only 3 days of use.620 The dose administered was .2mg/kg, or roughly 18mg for a person weighing 200lbs. Plasma binding proteins such as SHBG act to temporarily constrain steroid hormones from exerting activity in the body, and effectively reduce the available percentage of free (active) steroid. Oral stanozolol may be useful for providing a greater percentage of unbound steroid in the body, especially when taken in combination with a hormone that is more avidly bound by SHBG, such as testosterone.

Side Effects:

1 - Side Effects (Estrogenic):

Stanozolol is not aromatized by the body, and is not measurably estrogenic. An anti-estrogen is not necessary when using this steroid, as gynecomastia should not be a concern even among sensitive individuals. Since estrogen is the usual culprit with water retention, stanozolol instead produces a lean, quality look to the physique with no fear of excess subcutaneous fluid retention. This makes it a favorable steroid to use during cutting cycles, when water and fat retention are major concerns. Stanozolol is also very popular among athletes in combination strength/speed sports such as Track and Field. In such disciplines one usually does not want to carry around excess water weight, and may find the raw muscle-growth brought about by stanozolol to be quite favorable over the lower quality mass gains of aromatizable agents.

2 - Side Effects (Androgenic):

Although classified as an anabolic steroid, androgenic side effects are still common with this substance. This may include bouts of oily skin, acne, and body/facial hair growth. Anabolic/androgenic steroids may also aggravate male pattern hair loss. Women are also warned of the potential virilizing effects of anabolic/androgenic steroids. These may include a deepening of the voice, menstrual irregularities, changes in skin texture, facial hair growth, and clitoral enlargement. Additionally, the 5-alpha reductase enzyme does not metabolize stanozolol, so its relative androgenicity is not affected by finasteride or dutasteride. Stanozolol is a steroid with relatively low androgenic activity in relation to its tissue-building actions, making the threshold for strong androgenic side effects comparably higher than more androgenic agents such as testosterone, methandrostenolone, or fluoxymesterone.

3 - Side Effects (Hepatotoxicity):

Stanozolol is a c17-alpha alkylated compound. This alteration protects the drug from deactivation by the liver, allowing a very high percentage of the drug entry into the bloodstream following oral administration. C17-alpha alkylated anabolic/androgenic steroids can be hepatotoxic. Prolonged or high exposure may result in liver damage. In rare instances life-threatening dysfunction may develop. It is advisable to visit a physician periodically during each cycle to monitor liver function and overall health. Intake of c17- alpha alkylated steroids is commonly limited to 6-8 weeks, in an effort to avoid escalating liver strain. Stanozolol appears to offer less hepatic stress than an equivalent dose of Dianabol (methandrostenolone). Studies giving 12mg of stanozolol per day for 27 weeks failed to demonstrate clinically-significant changes in markers of liver function, including serum aspartate amino-transferase, alanine amino-transferase, gamma-glutamyltransferase, bilirubin, and alkaline phosphatase.621 Relative hepatotoxicity increases as the dosage escalates, so hepatic dysfunction should still be a concern. In rare instances, high doses (alone or in combination with other steroids) have been implicated in cases of serious life-threatening hepatotoxicity in bodybuilders. Injectable stanozolol has also been implicated in severe hepatotoxicity in an otherwise healthy bodybuilder,622 and should not be used as an alternative medication when liver toxicity precludes oral stanozolol use. The use of a liver detoxification supplement such as Liver Stabil, Liv-52, or Essentiale Forte is advised while taking any hepatotoxic anabolic/androgenic steroids.

4 - Side Effects (Cardiovascular):

Anabolic/androgenic steroids can have deleterious effects on serum cholesterol. This includes a tendency to reduce HDL (good) cholesterol values and increase LDL (bad) cholesterol values, which may shift the HDL to LDL balance in a direction that favors greater risk of arteriosclerosis. The relative impact of an anabolic/androgenic steroid on serum lipids is dependant on the dose, route of administration (oral vs. injectable), type of steroid (aromatizable or nonaromatizable), and level of resistance to hepatic metabolism. Stanozolol has a strong effect on the hepatic management of cholesterol due to its structural resistance to liver breakdown, non-aromatizable nature, and route of administration. Studies using an oral dose of 6 mg per day for six weeks demonstrated a mean serum HDL reduction of 33% in healthy male weight-training subjects, which was combined with a 29% increase in serum LDL.623 Anabolic/androgenic steroids may also adversely affect blood pressure and triglycerides, reduce endothelial relaxation, and support left ventricular hypertrophy, all potentially increasing the risk of cardiovascular disease and myocardial infarction. Injectable stanozolol has also been documented to produce strong negative changes in serum lipids. One study was carried out on a group of 12 healthy male subjects, and demonstrated a measurable reduction in HDL cholesterol values, as well as an increase in LDL and total cholesterol values, following a single injection of 50 mg.624 These changes persisted for 4 weeks after the drug was administered, and represent a potential increased risk for developing arteriosclerosis. Injectable stanozolol should not be used as an alternative medication when cardiovascular risk factors preclude oral stanozolol use. To help reduce cardiovascular strain it is advised to maintain an active cardiovascular exercise program and minimize the intake of saturated fats, cholesterol, and simple carbohydrates at all times during active AAS administration. Supplementing with fish oils (4 grams per day) and a natural cholesterol/antioxidant formula such as Lipid Stabil or a product with comparable ingredients is also recommended.

5 - Side Effects (Testosterone Suppression):

All anabolic/androgenic steroids when taken in doses sufficient to promote muscle gain are expected to suppress endogenous testosterone production. Stanozolol is no exception, and is noted for its strong influence on the hypothalamic-pituitary-testicular axis. Clinical studies giving 10 mg per day to healthy male subjects for 14 days caused the mean plasma testosterone level to fall by 55%.625 Without the intervention of testosterone-stimulating substances, testosterone levels should return to normal within 1-4 months of drug secession. Note that prolonged hypogonadotrophic hypogonadism can develop secondary to steroid abuse, necessitating medical intervention.

Dose:

Studies have shown that taking an oral anabolic steroid with food may decrease its bioavailability.626 This is caused by the fat-soluble nature of steroid hormones, which can allow some of the drug to dissolve with undigested dietary fat, reducing its absorption from the gastrointestinal tract. For maximum utilization, oral forms of stanozolol should be taken on an empty stomach. There can be large discrepancies in the steroid particle size between injectable stanozolol preparations. For example, Winstrol from Zambon (Spain) was designed for human use, and uses a refined powder that will pass through a 27-gauge needle. Winstrol®-V is a veterinary product in the U.S. and Canada, and has larger particles that will jam in needles smaller than 22-gauge. Solutions that utilize a larger particle size may also cause more discomfort at the site of injection. Injectable forms of stanozolol can be taken in measured oral doses should injection prove intolerable.

Male:

The original prescribing guidelines for Winstrol called for a daily dosage of 6 mg, which was administered on a schedule of one 2 mg tablet three times per day. The usual dosage for physique- or performance-enhancing purposes is between 15 mg and 25 mg per day, or three to five 5 mg tablets, taken for no longer than 6-8 weeks. Injectable Winstrol is generally recommended at a clinical dosage of one 50 mg injection every 2-3 weeks. When used for physique- or performanceenhancing purposes, a dosage of 50 mg every other day is most commonly applied. Veterinary stanozolol preparations with a larger particle size will be more slowly dispersed by the body, and are commonly given at 75 mg every third day. Doses of 50 mg per day with injectable stanozolol are not uncommon, although probably not advised. Note that injectable forms of the drug are expected to have, milligram for milligram, a greater anabolic effect than oral.627 Stanozolol is often combined with other steroids for a more dramatic result. For example, while bulking one might opt to add in 200-400 mg of a testosterone ester (cypionate, enanthate, or propionate) per week. The result should be a considerable gain in new muscle mass, with a more comfortable level of water and fat retention than if taking a higher dose of testosterone alone. For dieting phases, one might alternately combine stanozolol with a non-aromatizing steroid such as 150 mg per week of a trenbolone ester or 200-300 mg of Primobolan® (methenolone enanthate). Such stacks are highly favored for increasing definition and muscularity. An in-between (lean mass gain) might be to add in 200-400 mg of a low estrogenic compound like DecaDurabolin® (nandrolone decanoate) or Equipoise® (boldenone undecylenate).

Female:

The original prescribing guidelines for Winstrol called for a daily dosage of 4 mg (one 2mg tablet twice daily) with young women particularly susceptible to the androgenic effects of anabolic steroids. This dosage was increased to 6mg (the same as the recommended dose for males) when necessary. When used for physique- or performance-enhancing purposes, a dosage of 5 mg to 10 mg daily is most common, taken for no longer than 4-6 weeks. Injectable Winstrol is generally recommended at a clinical dose of 50 mg every 2-3 weeks. The injectable is usually not advised with women for physique- or performance-enhancing purposes, as it allows for less control over blood hormone levels. Those women who absolutely must use the injectable commonly administer 25 mg every 3 or 4 days. Although this compound is weakly androgenic, the risk of virilization symptoms cannot be completely excluded, even at therapeutic doses.

Stanozolol USP29, Ph.Eur.5.5, Micronized grade

Molecular Formula: C22H36N2O

Molecular Weight: 344.53 gm/mol

Active life: 8 hours

Detection Time: 3 weeks

Anabolic/Androgenic Ratio (Range): 320:30

DESCRIPTION:

Stanozolol®, brand of Stanozolol tablets, is an anabolic steroid, a synthetic derivative of testosterone. Each tablet contains 5 mg and 10 mg of Stanozolol USP29, Ph.Eur.5.5, micronized grade. It is designated chemically as 17-methyl-2'H -5α-androst-2eno[3,2-c]pyrazol-17β-ol.

Each tablet also contains lactose monohydrate, sodium starch glycolate, polyvidone 25,000, microcrystalline cellulose and magnesium stearate as excipients. The 5 mg tablet also contains yellow ferric oxide (E172) and indigo carmine aluminium lake (E132) as colouring agent and the 10 mg tablet also contains yellow ferric oxide (E172)

Stanozolol® is an oral androgen derived from dihydrotestosterone. Stanozolol® acts on androgen receptors to promote anabolism through increased nitrogen retention and protein synthesis in muscle tissue. Stanozolol® is a strong anabolic substance with androgenic action. Stanozolol does not convert to estrogen and therefore does not produce typical estrogen mediated side effects such as water retention. Stanozolol has a large oral bioavailability, due to a C17 a-alkylation which allows the hormone to survive first pass liver metabolism. Stanozolol reduces SHBG increasing free testosterone levels.

Stanozolol Oral

Alternative Names:

Androstanazole,Methylstanazole

Proprietary Names:

Stromba (5 mg.),Winstrol (2 mg.)

Chemical Name:

17alpha-Methyl-2’H-5alpha-androst-2-eno(3,2-c)pyrazol-17beta-ol

Description:

Stanozolol has anabolic and androgenic properties and has been used in the treatment of vascular manifestations of Behcet’s syndrome and in the management of hereditary angioedema. Stanozolol, when given for prolonged periods, has been associated with elevated liver function results since it is an 17alpha-alkylated compound.

Stanozolol tablets have a reputation for causing gastrointestinal discomfort after prolonged use. Both the tablets and injection form are not considered to aromatise. Tablets are often taken in divided doses to reduce gastric irritation. This practice is popular with female users, as it reduced the risks of virilization which is associated with large amounts of androgens in the female system.

Dose:

2.5 – 10 mg. daily.

Male: 15 – 30 mg. daily,

Female: 10 – 15 mg. daily.

RAD-140, also known as Testolone, is a selective androgen receptor modulator (SARM). It is a synthetic compound that binds to androgen receptors in the body, mimicking the effects of testosterone.

RAD-140 is primarily studied for its potential in muscle-building and increasing bone density, with fewer androgenic side effects compared to traditional anabolic steroids. It is believed to selectively target muscle and bone tissue, promoting muscle growth and improving bone density without significantly affecting other tissues in the body.

In preclinical studies, RAD-140 has shown promising results in increasing lean muscle mass, enhancing physical performance, and improving bone health, making it a subject of interest in the fitness and bodybuilding communities.

However, like other SARMs, RAD-140 is still undergoing clinical trials to determine its safety and efficacy. While it may offer potential benefits for muscle growth and athletic performance, its long-term effects and safety profile are not yet fully understood. Therefore, its use outside of medical settings is not recommended, and it should only be used under the supervision of a qualified healthcare professional for legitimate medical purposes

--------------------------

Vosilasarm (RAD140, EP0062, Testolone)

Structure Characteristic:

2-chloro-4-[[(1R,2S)-1-[5-(4-cyanophenyl)-1,3,4-oxadiazol-2-yl]-2-hydroxypropyl]amino]-3- methylbenzonitrile

HALF-LIFE: 24 hours

DOSE: 10 – 20 mg.-day

CYCLE LENGTH: 8 weeks

Benefit:

1 - MUSCLE

Testolone is known for its ability to accrue a significant amount of lean muscle mass in short periods of time. It will not add as much weight as something like Ligandrol, but it won’t cause water retention either, meaning that what you gain will be purely lean muscle mass. Gains of up to 8 lbs can be expected after 8 weeks. The consensus among users of SARMs is that both Ligandrol and Testolone add a similar amount of muscle mass, with the latter being drier and therefore more cosmetically pleasing. The lack of water retention makes Testolone a very versatile compound, both useful for a lean bulk or a cutting cycle. Like all SARMs, it will retain and even increase muscle mass while on a caloric deficit.

2 - STRENGTH AND PERFORMANCE

Testolone is famously known for its performance enhancing benefits. Your strength will shoot through the roof and your stamina will be never-ending. Users often report increased aggression and impatience when taking Testolone.

This can be seen as a negative side-effect outside of the gym, but when working out that aggression translates into better focus and performance.

3 - FAT LOSS

Contrary to what some people claim, Testolone will not make you lose more fat. However, since it is a dry SARM it will make you look leaner and tighter than you really are. Like all SARMs, it is excellent at keeping muscle mass and even increasing it while on a caloric deficit.

4 - BONES AND JOINTS

Testolone, like all SARMs, will increase the density and strength of your bones. It does not appear to have any impact on joints nor tendons.

5 - RECOVERY

Testolone will make your recovery faster. You will feel less soreness the next day and you will be able to work out those same muscles sooner. It is hard to tell whether it is better than other SARMs at doing this, but given how powerful it is, it would be safe to assume that it is more effective than at boosting recovery than weaker SARMs.

6 - COSMETIC BENEFITS

Testolone is one of the best SARMs when it comes to improving aesthetics. It will make your muscles dry, hard and tight. Users also report better pumps, more vascularity and a more 3D look to their muscles.

7 - OTHER BENEFITS

It has been proven to be effective at fighting breast cancer, reducing prostate size and protecting the brain in rats, so it can potentially do that in humans as well.

— Testolone does not alter liver enzymes significantly (proven empirically with bloodwork).

— Improved libido and sense of wellbeing (anecdotal and empirical proven), possibly due to its antagonistic effect on estrogen receptors.

Side Effect:

1 - TESTOSTERONE SUPPRESSION

Testolone, like all SARMs, will cause a significant drop in your Testosterone levels. Testolone is a moderately suppressive SARM, and proper measures must be taken in order to manage and reverse this suppression. The consequences of this drop in your testosterone levels can be: - Decreased libido - Weaker erections - Lethargy - Lack of motivation - Irritability - Testicular atrophy - Testicular pain The suppression of testosterone levels will be more noticeable during a cycle of Testolone than it will be during a cycle of Ostarine or Andarine. In fact, some users struggle so much with the suppression that they have to cut their cycle short at week 6 or 7. As you can see, it is similar in terms of suppression to Ligandrol, with some people claiming that Testolone is more suppressive and some people claiming that Ligandrol is worse.

Thankfully, there are things that can be taken in order to mitigate this side-effect. (More information on this in the chapters about On-Cycle Therapy and Post-Cycle Therapy). It is worth noting that Testolone, like all SARMs, will decrease your SHBG. This will lead to an increase in your free testosterone levels which usually causes libido, motivation and well-being to improve during the first few weeks of the cycle, until the suppression of the Total Testosterone levels offsets the increase in Free Testosterone.

2 - CHOLESTEROL

Testolone, like all SARMs, will mess with your HDL and LDL cholesterol levels. Your HDL (good) cholesterol will be significantly decreased, and your LDL (bad) cholesterol will probably increase. This side-effect will not manifest itself by impacting the way you feel, so you will have no symptoms. Getting bloodwork at the end of a cycle will show the true impact of the SARM on your lipid panel.

3 - LIVER TOXICITY

It is unclear whether RAD-140 is hepatotoxic or not, because we have anecdotal bloodwork showing elevated AST and ALT levels, as well as anecdotal bloodwork showing no signs of liver toxicity whatsoever. One of the goals of the Clinical Trial that Testolone is currently undergoing is finding out whether liver toxicity is a concern with this SARM. For the sake of safety, you should not drink during a cycle of Testolone (or of any other SARM) and you should include some form of liver protection in your cycle (More info on this on the chapter about On-Cycle Therapy).

4 - HAIR SHEDDING

While this side effect can also happen with other SARMs, reports of hair shedding are way more common for Testolone than any other SARM. The cause is unknown, but thankfully it only happens to a small minority of people and it tends to be reversible after the cycle.

5 - AGGRESSION

As mentioned before, Testolone is known for causing increased aggression, sometimes in the form of irritability or impatience. This is obviously a negative side-effect, but it can be a positive benefit in the gym.

6 - OTHER SIDE-EFFECTS

There are some side effects that only happen to an extremely small minority of people. For example:

- Gynecomastia:

The growth of breast tissue on males. This is an extremely rare side effect that is caused by an imbalance between your estrogen and testosterone levels. Men who have had pubertal gynecomastia are at risk of developing it if they take Testolone.

- Insomnia:

This is another rare side-effect that some people experience. This one is entirely unpredictable but can be mitigated easily.

Oxymetholone

BENEFIT:

Oxymetholone has anabolic and androgenic properties. It is used orally in the treatment of anaemias such as aplastic anaemias.

SIDE EFFECT:

1 - Oxymetholone is 17alpha-alkylated, with liver disturbances and jaundice common even in therapeutic doses. There has also been links between Oxymetholone treatment and the development of leukemia.

2 - Oxymetholone, a derivative of dihydrotestosterone (DHT) and is commonly recognized as the strongest oral anabolic steroid available. It is both highly anabolic and androgenic and being 17 alpha alkylated, very toxic to the liver. There have been many reports of acne and hair loss (due to high levels of DHT) in addition to its strong association with liver damage and gynecomastia. There have also been reports of headaches and stomach pains. There is substantial evidence of loss of size and weight, which has been attributed to the drug being too ‘hard on the body’. Very few women can tolerate oxymetholone due to its virilizing effects.

3 – Estrogenic issue:

Oxymetholone is a highly estrogenic steroid. Gynecomastia is often a concern during treatment and may present itself quite early into a cycle (particularly when higher doses are used). At the same time water retention can become a problem, causing a notable loss of muscle definition as both subcutaneous water retention and fat levels build. To avoid strong estrogenic side effects, it may be necessary to use an anti-estrogen such as Nolvadex® or Clomid®. It is important to note that oxymetholone does not directly convert to estrogen in the body. This steroid is a derivative of dihydrotestosterone, and as such cannot be aromatized. Anti-aromatase compounds such as Cytadren and Arimidex® will, likewise, not affect the relative estrogenicity of this steroid. Some have suggested that the high level of estrogenic activity in oxymetholone is due to the drug acting as a progestin, like nandrolone. The side effects of both estrogens and progestins can be very similar, which might have made this explanation a plausible one. There was a medical study examining the progestational activity of oxymetholone, however, and it determined that there was no such activity present.386 With such findings, it seems most plausible that oxymetholone can activate the estrogen receptor, like, but more profoundly than, the estrogenic androgen methandriol.

4 – Androgenic issue:

Although oxymetholone is classified as an anabolic steroid, androgenic side effects are still possible with this substance. These may include bouts of oily skin, acne, and body/facial hair growth. Higher doses are more likely to cause such side effects. Anabolic/androgenic steroids may also aggravate male pattern hair loss. Women are additionally warned of the potential virilizing effects of anabolic/androgenic steroids. These may include a deepening of the voice, menstrual irregularities, changes in skin texture, facial hair growth, and clitoral enlargement. While Anadrol is classified as an anabolic steroid, it does retain a notable androgenic component. It is interesting to note that oxymetholone does exhibit some tendency to convert to dihydrotestosterone in the body, although this does not occur via the 5-alpha reductase enzyme. Oxymetholone is already a dihydrotestosteronebased steroid, so no such alteration can take place. Aside from the added c-17 alpha alkylation (discussed below), oxymetholone differs from DHT only by the addition of a 2- hydroxymethylene group. This grouping can be removed metabolically, reducing oxymetholone to the potent androgen 17alpha-methyl dihydrotestosterone (mestanolone).387 There is little doubt that this biotransformation contributes at least on some level to the androgenic nature of this steroid. Note that since 5-alpha reductase is not involved, the relative androgenicity of oxymetholone is not affected by the concurrent use of finasteride or dutasteride.

5 – Hepatotoxicity issue:

Oxymetholone is a c17-alpha alkylated compound. This alteration protects the drug from deactivation by the liver, allowing a very high percentage of the drug entry into the bloodstream following oral administration. C17-alpha alkylated anabolic/androgenic steroids can be hepatotoxic. Prolonged or high exposure may result in liver damage. In rare instances life-threatening dysfunction may develop. It is advisable to visit a physician periodically during each cycle to monitor liver function and overall health. Intake of c17- alpha alkylated steroids is commonly limited to 6-8 weeks, in an effort to avoid escalating liver strain. Oxymetholone has a saturated A-ring, which slightly reduces its relative hepatotoxicity.388 Still, this agent, particularly at the doses commonly used, can present substantial hepatotoxicity to the user. Studies administering 50 mg or 100 mg daily to 31 elderly men for 12 weeks produced significant increases in liver enzymes (transaminases AST and ALT) only in patients taking 100 mg. A second study administering 50 mg daily to 30 patients for up to and exceeding one year (in some patients) has demonstrated elevations in y-glutamyltransferase (GGT) in 17% of patients, significant increases in bilirubin in 10%, and serum albumin increases in 20%.389 One patient developed a liver tumor that could have been peliosis hepatitis, a lifethreatening adverse event characterized by blood filled cysts in the liver. A small number of other cases of peliosis hepatitis have been linked to oxymetholone, suggesting the potential for hepatotoxicity should still be carefully considered before use. The use of a liver detoxification supplement such as Liver Stabil, Liv-52, or Essentiale Forte is advised while taking any hepatotoxic anabolic/androgenic steroids.

6 – Cardiovascular issue:

Anabolic/androgenic steroids can have deleterious effects on serum cholesterol. This includes a tendency to reduce HDL (good) cholesterol values and increase LDL (bad) cholesterol values, which may shift the HDL to LDL balance in a direction that favors greater risk of arteriosclerosis. The relative impact of an anabolic/androgenic steroid on serum lipids is dependent on the dose, route of administration (oral vs. injectable), type of steroid (aromatizable or nonaromatizable), and level of resistance to hepatic metabolism. Anabolic/androgenic steroids may also adversely affect blood pressure and triglycerides, reduce endothelial relaxation, and support left ventricular hypertrophy, all potentially increasing the risk of cardiovascular disease and myocardial infarction. Oxymetholone has a strong effect on the hepatic management of cholesterol due to its structural resistance to liver breakdown and route of administration. Studies administering 50 mg or 100 mg daily to a group of elderly men for 12 weeks have demonstrated insignificant increases in LDL cholesterol, accompanied by very significant (dramatic) suppressions of HDL cholesterol (reduced 19 and 23 points in the 50 mg and 100 mg groups, respectively).390 The use of oxymetholone should be undertaken only after careful consideration in people with high cholesterol or a familial history of heart disease. To help reduce cardiovascular strain it is advised to maintain an active cardiovascular exercise program and minimize the intake of saturated fats, cholesterol, and simple carbohydrates always during active AAS administration. Supplementing with fish oils (4 grams per day) and a natural cholesterol/antioxidant formula such as Lipid Stabil or a product with comparable ingredients is also recommended.

7 – Testosterone Suppression:

All anabolic/androgenic steroids, when taken in doses sufficient to promote muscle gain are expected to suppress endogenous testosterone production. Without the intervention of testosterone stimulating substances, testosterone levels should return to normal within 1-4 months of drug secession. Note that prolonged hypogonadotrophic hypogonadism can develop secondary to steroid abuse, necessitating medical intervention. Note that when discontinuing oxymetholone, the crash can be as equally powerful as the on-cycle results. To begin with, the level of water retention will quickly diminish, dropping the user’s body weight dramatically. This should be expected, and not of much concern. What is usually of most concern is restoring endogenous testosterone production with a proper PCT program (Post Cycle Therapy). Before going off, some alternately choose to first switch over to a milder injectable like Deca-Durabolin® for several weeks. This is to “harden up the new mass,” and can prove to be an effective practice, at least from a mental standpoint. A drop of weight is likely when making the switch, although the result is still often viewed as allowing the retention of more (quality) muscle mass. It is sort of stepping down, first off, the water retention, and weeks later finally off the hormones. Remember ancillaries though, as testosterone production will not be rebounding during Deca therapy.

Dose:

Male: Up to 100 mg. daily.

Early prescribing guidelines for oxymetholone recommended a dosage of 2.5 mg three times per day to reverse the wasting process and provide lean body mass gain. Doses as high as 30 mg were employed in some cases. Current prescribing guidelines recommend a dosage of 1-5 mg per kilogram of bodyweight per day for treating anemia, although indicate that a dose of 1-2 mg/kg is typically sufficient. A 175-pound person would take approximately 150 mg per day at the 2 mg/kg dosage level. In some other countries, it is recommended to limit the dosing of oxymetholone to 100 mg per day. Therapy is usually given for a minimum of three to six months. When used for physique- or performance enhancing purposes, an effective oral daily dosage would fall in the range of 25-150 mg, taken in cycles lasting no more than 6-8 weeks to minimize hepatotoxicity. This level is sufficient for dramatic increases in muscle mass and strength. Higher doses are rarely administered due to the strong estrogenic nature of the drug, as well as the high potential for hepatotoxicity. When used for physique- or performance-enhancing purposes, an effective oral daily dosage would fall in the range of 25-150 mg, taken in cycles lasting no more than 6-8 weeks to minimize hepatotoxicity. This level is sufficient for dramatic increases in muscle mass and strength. Higher doses are rarely administered due to the strong estrogenic nature of the drug, as well as the high potential for hepatotoxicity.

Female:

not recommended for women for physique- or performance-enhancing purposes due to its very strong nature and tendency to produce virilizing side effects.

Oxandrolone

Proprietary Names:

Anavar (2.5 mg.),Lipidex (2.5 mg.),Lonavar (2 mg.),Oxandrin (2.5 mg.),Vasorome (2.5 mg.)

Oxandrolone is rapidly absorbed from the gastro-intestinal tract, resulting in a maximum plasma concentration between 30 and 90 minutes and a plasma half-life of about 9 hours.

Oxandrolone Benefit:

1 - Oxandrolone is an oral anabolic steroid derived from dihydrotestosterone. It was designed to have a very strong separation of anabolic and androgenic effect, and no significant estrogenic or progestational activity. Oxandrolone is noted for being quite mild as far as oral steroids are concerned, well tailored for the promotion of strength and quality muscle tissue gains without significant side effects. Milligram for milligram it displays as much as six times the anabolic activity of testosterone in assays, with significantly less androgenicity.402 This drug is a favorite of dieting bodybuilders and competitive athletes in speed/anaerobic performance sports, where its tendency for pure tissue gain (without fat or water retention) fits well with the desired goals.

2 - Oxandrolone has been given orally in the treatment of constitutional delayed growth and puberty in boys. Courses of treatment are short (about 3 to 4 months) because of the risk of epiphyseal closure. Oxandrolone has been prescribed to post-menopausal women in the treatment of osteoporosis.

Oxandrolone Side Effects:

1 - Oxandrolone is also under investigation in the treatment of Turner’s syndrome in girls. As Oxandrolone is C17 alpha-alkylated there is the potential for liver damage.

2 - Oxandrolone has relatively low androgenic properties, with little aromatization in males. It has a reputation for increasing strength but not size. It is popular with women because of its low incidence of side-effects de to virilization. However, some cases of facial hair growth and deepening of the voice have been reported following prolonged dosages. Gastrointestinal irritation, including pain and diarrhea are commonly reported side-effects in both male and female users.

3 – Estrogenic issue:

Oxandrolone is not aromatized by the body and is not measurably estrogenic. Oxandrolone also offers no related progestational activity.404 An anti-estrogen is not necessary when using this steroid, as gynecomastia should not be a concern even among sensitive individuals. Since estrogen is the usual culprit with water retention, oxandrolone instead produces a lean, quality look to the physique with no fear of excess subcutaneous fluid retention. This makes it a favorable steroid to use during cutting cycles, when water and fat retention are major concerns. Oxandrolone is also very popular among athletes in strength/speed sports such as sprinting, swimming, and gymnastics. In such disciplines one usually does not want to carry around excess water weight and may find the raw muscle-growth brought about by oxandrolone to be quite favorable over the lower quality mass gains of aromatizable agents.

4 – Androgenic issue:

Although classified as an anabolic steroid, androgenic side effects are still possible with this substance. This may include bouts of oily skin, acne, and body/facial hair growth. Anabolic/androgenic steroids may also aggravate male pattern hair loss. Women are warned of the potential virilizing effects of anabolic/androgenic steroids. These may include a deepening of the voice, menstrual irregularities, changes in skin texture, facial hair growth, and clitoral enlargement. Oxandrolone is a steroid with low androgenic activity relative to its tissue-building actions, making the threshold for strong androgenic side effects comparably higher than with more androgenic agents such as testosterone, methandrostenolone, or fluoxymesterone. The low androgenic activity of oxandrolone is due in part to it being a derivative of dihydrotestosterone. This creates a less androgenic steroid because the agent lacks the capacity to interact with the 5-alpha reductase enzyme and convert to a more potent “di-hydro” form. This is unlike testosterone, which is several times more active in androgen responsive target tissues such as the scalp, skin, and prostate (where 5- alpha reductase is present in high amounts) due to its conversion to DHT. In essence, oxandrolone has a more balanced level of potency between muscle and androgenic target tissues. This is a similar situation as is noted with Primobolan and Stanozolol, which are also derived from dihydrotestosterone and not known to be very androgenic substances.

5 – Hepatotoxicity issue:

Oxandrolone is a c17-alpha alkylated compound. This alteration protects the drug from deactivation by the liver, allowing a very high percentage of the drug entry into the bloodstream following oral administration. C17-alpha alkylated anabolic/androgenic steroids can be hepatotoxic. Prolonged or high exposure may result in liver damage. In rare instances life-threatening dysfunction may develop. It is advisable to visit a physician periodically during each cycle to monitor liver function and overall health. Intake of c17- alpha alkylated steroids is commonly limited to 6-8 weeks, in an effort to avoid escalating liver strain. Oxandrolone appears to offer less hepatic stress than other c17 alpha alkylated steroids. The manufacturer identifies oxandrolone as a steroid that is not extensively metabolized by the liver like other 17-alpha alkylated orals, which may be a factor in its reduced hepatotoxicity. This is evidenced by the fact that more than a third of the compound is still intact when excreted in the urine.405 Another study comparing the effects of oxandrolone to other alkylated agents including methyltestosterone, norethandrolone, fluoxymesterone, and methandriol demonstrated that oxandrolone causes the lowest sulfobromophthalein (BSP; a marker of liver stress) retention of the agents tested.406 20 mg of oxandrolone produced 72% less BSP retention than an equal dosage of fluoxymesterone, which is a considerable difference being that they are both 17-alpha alkylated. A more recent study looked at escalating doses (20 mg, 40 mg, and 80 mg) of oxandrolone in 262 HIV men. The drug was administered for a period of 12 weeks. The group taking 20 mg of oxandrolone per day showed no statistically significant trends of hepatotoxicity in liver enzyme (AST/ALT; amino-transferase and alanine aminotransferase) values. Those men taking 40 mg noticed a mean increase of approximately 30-50% in liver enzyme values, while the group of men taking 80 mg noticed an approximate 50-100% increase. Approximately 10-11% of the patients in the 40 mg group noticed World Health Organization grade III and IV toxicity according to AST and ALT values. This figure jumped to 15% in the 80 mg group. While serious hepatotoxicity cannot be excluded with oxandrolone, these studies do suggest that it is measurably safer than other alkylated agents. The use of a liver detoxification supplement such as Liver Stabil, Liv-52, or Essentiale Forte is advised while taking any hepatotoxic anabolic/androgenic steroids.

6 – Cardiovascular issue:

Anabolic/androgenic steroids can have deleterious effects on serum cholesterol. This includes a tendency to reduce HDL (good) cholesterol values and increase LDL (bad) cholesterol values, which may shift the HDL to LDL balance in a direction that favors greater risk of arteriosclerosis. The relative impact of an anabolic/androgenic steroid on serum lipids is dependant on the dose, route of administration (oral vs. injectable), type of steroid (aromatizable or nonaromatizable), and level of resistance to hepatic metabolism. Oxandrolone has a strong effect on the hepatic management of cholesterol due to its structural resistance to liver breakdown, non-aromatizable nature, and route of administration. In the previously cited study in HIV males, 20 mg of oxandrolone daily for 12 weeks caused a mean serum HDL reduction of 30%. HDL values were suppressed 33% in the 40 mg group, and 50% in the 80 mg group. This was accompanied by a statistically significant increase in LDL values (approximately 30-33%) in the 40 mg and 80 mg groups, further increasing atherogenic risk. Anabolic/androgenic steroids may also adversely affect blood pressure and triglycerides, reduce endothelial relaxation, and support left ventricular hypertrophy, all potentially increasing the risk of cardiovascular disease and myocardial infarction. At one time oxandrolone was looked at as a possible drug for those suffering from disorders of high cholesterol or triglycerides. Early studies showed it to be capable of lowering total cholesterol and triglyceride values in certain types of hyperlipidemic patients, which was thought to signify potential for this drug as a lipid-lowering agent.407 With further investigation it was found, however, that any lowering of total cholesterol values was accompanied by a redistribution in the ratio of good (HDL) to bad (LDL) cholesterol that favored greater atherogenic risk.408 409 This negates any positive effect this drug might have on triglycerides or total cholesterol, and actually makes it a potential danger in terms of cardiac risk, especially when taken for prolonged periods of time. Today we understand that as a group, anabolic/androgenic steroids tend to produce unfavorable changes in lipid profiles and are really not useful in disorders of lipid metabolism. As an oral c17 alpha alkylated steroid, oxandrolone is even more risky to use in this regard than an esterified injectable such as a testosterone or nandrolone. To help reduce cardiovascular strain it is advised to maintain an active cardiovascular exercise program and minimize the intake of saturated fats, cholesterol, and simple carbohydrates always during active AAS administration. Supplementing with fish oils (4 grams per day) and a natural cholesterol/antioxidant formula such as Lipid Stabil or a product with comparable ingredients is also recommended.

7 - Testosterone Suppression:

All anabolic/androgenic steroids when taken in doses sufficient to promote muscle gain are expected to suppress endogenous testosterone production. Oxandrolone is no exception. In the above-cited study on HIV males, twelve weeks of 20 mg or 40 mg per day caused an approximate 45% reduction in serum testosterone levels. The group taking 80 mg noticed a 66% decrease in testosterone. Similar trends of decrease were noticed in LH production, with the 20 mg and 40 mg doses causing a 25-30% reduction, and the 80 mg group noticing a decline of more than 50%. Additionally, studies on boys with constitutionally delayed puberty have demonstrated significant suppression of endogenous LH and testosterone with as little as 2.5 mg per day.410 Without the intervention of testosterone stimulating substances, testosterone levels should return to normal within 1-4 months of drug secession. Note that prolonged hypogonadotrophic hypogonadism can develop secondary to steroid abuse, necessitating medical intervention.

Oxandrolone Dose:

Male: 8 – 10 tablets daily

The original prescribing guidelines for Anavar called for a daily dosage of between 2.5 mg and 20 mg per day (5-10 mg being most common). This was usually recommended for a period of two to four weeks, but occasionally it was taken for as long as three months. The dosing guidelines recommended with the current U.S. production form of the drug (Oxandrin, Savient Pharmaceuticals) also call for between 2.5 and 20 mg of drug per day, taken in intermittent cycles of 2 to 4 weeks. The usual dosage for physique- or performance-enhancing purposes is in the range of 15-25 mg per day, taken for 6 to 8 weeks. These protocols are not far removed from those of normal therapeutic situations. Oxandrolone is often combined with other steroids for a more dramatic result. For example, while bulking one might opt to add in 200-400 mg of a testosterone ester (cypionate, enanthate, or propionate) per week. The result should be a considerable gain in new muscle mass, with a more comfortable level of water and fat retention than if taking a higher dose of testosterone alone. For dieting phases, one might alternately combine oxandrolone with a nonaromatizing steroid such as 150 mg per week of a trenbolone ester or 200-300 mg of Primobolan® (methenolone enanthate). Such stacks are highly favored for increasing definition and muscularity. An in-between (lean mass gain) might be to add in 200-400 mg of a low estrogenic compound like Deca-Durabolin® (nandrolone decanoate) or Equipoise® (boldenone undecylenate).

Female: 5 tablets daily

The original prescribing guidelines for Anavar did not offer separate dosing recommendations for women, although it was indicated that women who were pregnant, or may become pregnant, should not use the drug. The current guidelines for Oxandrin also do not make special dosing recommendations for women. Women who fear the masculinizing effects of many steroids would be quite comfortable using this drug, as these properties are very rarely seen with low doses. For physique- or performanceenhancing purposes, a daily dosage of 5-10 mg should illicit considerable growth without the noticeable androgenic side effects of other drugs. This would be taken for no longer than 4-6 weeks. Eager females may wish to add another mild anabolic such as Winstrol®, Primobolan® or Durabolin®. When combined with such anabolics, the user should notice faster, more pronounced muscle-building effects, but it may also increase the likelihood of seeing androgenic side effects (or hepatotoxicity in the case of Winstrol).

Oxandrolone Cycle:

Oxandrolone, commonly known as Anavar, is an anabolic steroid that is often used for performance enhancement, particularly in bodybuilding and athletics. An Oxandrolone cycle refers to a period during which an individual uses Oxandrolone as part of their steroid regimen.

The specifics of an Oxandrolone cycle can vary depending on factors such as the individual's goals, experience with steroids, and tolerance to the drug. However, typical cycles might involve taking Oxandrolone orally in tablet form for a set duration, usually ranging from 6 to 12 weeks.

A common Oxandrolone cycle might look something like this:

1. Start with a Low Dose: Beginners typically start with a lower dosage to assess tolerance and minimize potential side effects. A common starting dosage might be around 20-30mg per day.
2. Gradual Increase: Depending on how the individual responds, the dosage may be gradually increased over the course of the cycle. However, it's essential to be cautious and not exceed recommended dosages to avoid adverse effects.
3. Mid-Cycle Evaluation: Around halfway through the cycle, individuals may evaluate their progress and adjust dosage or other aspects of their regimen as needed.
4. Post-Cycle Therapy (PCT): After completing the Oxandrolone cycle, individuals often undergo a post-cycle therapy regimen to help restore natural hormone production, minimize potential side effects, and maintain gains achieved during the cycle. PCT may involve the use of medications such as SERMs (Selective Estrogen Receptor Modulators) like Clomid or Nolvadex.

It's crucial to note that the use of anabolic steroids like Oxandrolone should be approached with caution and under the supervision of a qualified medical professional. Misuse or abuse of steroids can lead to various health risks and side effects, including liver damage, cardiovascular issues, hormonal imbalances, and more. Additionally, the use of steroids for performance enhancement is often prohibited in sports and can result in serious consequences for athletes if detected

Nandrolone Phenylpropionate, Durabolin

Nandrolone phenylpropionate or Durabolin is an injectable form of the anabolic steroid nandrolone. The properties of this drug are strikingly similar to those of Deca-Durabolin®, which uses the slower acting drug nandrolone decanoate. The primary difference between these two preparations is the speed in which nandrolone is released into the blood. While nandrolone decanoate provides a release of nandrolone from the area of injection lasting approximately 3 weeks, nandrolone phenylpropionate is active for only about a week. In clinical situations, Deca-Durabolin can thus be injected once every 2 or 3 weeks, while Durabolin® is usually administered every several days to once weekly. Otherwise, the two drugs are virtually interchangeable.

Nandrolone Phenylpropionate Benefit:

Like DecaDurabolin, Durabolin is valued by athletes and bodybuilders for its abilities to promote strength and lean muscle mass gains without significant estrogenic or androgenic side effects. 

Nandrolone Phenylpropionate Side Effect:

1 – Estrogenic issue:

Nandrolone has a low tendency for estrogen conversion, estimated to be only about 20% of that seen with testosterone.472 This is because while the liver can convert nandrolone to estradiol, in other more active sites of steroid aromatization such as adipose tissue nandrolone is far less open to this process.473 Consequently, estrogen- related side effects are a much lower concern with this drug than with testosterone. Elevated estrogen levels may still be noticed with higher dosing, however, and may cause side effects such as increased water retention, body fat gain, and gynecomastia. An anti-estrogen such as clomiphene citrate or tamoxifen citrate may be necessary to prevent estrogenic side effects if they occur. One may alternately use an aromatase inhibitor like Arimidex® (anastrozole), which more efficiently controls estrogen by preventing its synthesis. Aromatase inhibitors can be quite expensive in comparison to anti-estrogens, however, and may also have negative effects on blood lipids. It is of note that nandrolone has some activity as a progestin in the body.474 Although progesterone is a c-19 steroid, removal of this group as in 19-norprogesterone creates a hormone with greater binding affinity for its corresponding receptor. Sharing this trait, many 19-nor anabolic steroids are shown to have some affinity for the progesterone receptor as well.475 The side effects associated with progesterone are similar to those of estrogen, including negative feedback inhibition of testosterone production and enhanced rate of fat storage. Progestins also augment the stimulatory effect of estrogens on mammary tissue growth. There appears to be a strong synergy between these two hormones here, such that gynecomastia might even occur with the help of progestins, without excessive estrogen levels. The use of an antiestrogen, which inhibits the estrogenic component of this disorder, is often sufficient to mitigate gynecomastia caused by nandrolone.

2 – Androgenic issue:

Although classified as an anabolic steroid, androgenic side effects are still possible with this substance, especially with higher doses. This may include bouts of oily skin, acne, and body/facial hair growth. Anabolic/androgenic steroids may also aggravate male pattern hair loss. Women are warned of the potential virilizing effects of anabolic/androgenic steroids. These may include a deepening of the voice, menstrual irregularities, changes in skin texture, facial hair growth, and clitoral enlargement. Nandrolone is a steroid with relatively low androgenic activity relative to its tissuebuilding actions, making the threshold for strong androgenic side effects comparably higher than with more androgenic agents such as testosterone, methandrostenolone, or fluoxymesterone. It is also important to point out that due to its mild androgenic nature and ability to suppress endogenous testosterone, nandrolone is prone to interfering with libido in males when used without another androgen. Note that in androgen-responsive target tissues such as the skin, scalp, and prostate, the relative androgenicity of nandrolone is reduced by its reduction to dihydronandrolone (DHN).476 477 The 5-alpha reductase enzyme is responsible for this metabolism of nandrolone. The concurrent use of a 5-alpha reductase inhibitor such as finasteride or dutasteride will interfere with site-specific reduction of nandrolone action, considerably increasing the tendency of nandrolone to produce androgenic side effects. Reductase inhibitors should be avoided with nandrolone if low androgenicity is desired.

3 – Androgenic issue:

Although classified as an anabolic steroid, androgenic side effects are still possible with this substance, especially with higher doses. This may include bouts of oily skin, acne, and body/facial hair growth. Anabolic/androgenic steroids may also aggravate male pattern hair loss. Women are warned of the potential virilizing effects of anabolic/androgenic steroids. These may include a deepening of the voice, menstrual irregularities, changes in skin texture, facial hair growth, and clitoral enlargement. Nandrolone is a steroid with relatively low androgenic activity relative to its tissuebuilding actions, making the threshold for strong androgenic side effects comparably higher than with more androgenic agents such as testosterone, methandrostenolone, or fluoxymesterone. It is also important to point out that due to its mild androgenic nature and ability to suppress endogenous testosterone, nandrolone is prone to interfering with libido in males when used without another androgen. Note that in androgen-responsive target tissues such as the skin, scalp, and prostate, the relative androgenicity of nandrolone is reduced by its reduction to dihydronandrolone (DHN).476 477 The 5-alpha reductase enzyme is responsible for this metabolism of nandrolone. The concurrent use of a 5-alpha reductase inhibitor such as finasteride or dutasteride will interfere with site-specific reduction of nandrolone action, considerably increasing the tendency of nandrolone to produce androgenic side effects. Reductase inhibitors should be avoided with nandrolone if low androgenicity is desired.

4 – Cardiovascular issue:

Anabolic/androgenic steroids can have deleterious effects on serum cholesterol. This includes a tendency to reduce HDL (good) cholesterol values and increase LDL (bad) cholesterol values, which may shift the HDL to LDL balance in a direction that favors greater risk of arteriosclerosis. The relative impact of an anabolic/androgenic steroid on serum lipids is dependant on the dose, route of administration (oral vs. injectable), type of steroid (aromatizable or nonaromatizable), and level of resistance to hepatic metabolism. Studies administering 600 mg of nandrolone decanoate per week for 10 weeks demonstrated a 26% reduction in HDL cholesterol levels.478 This suppression is slightly greater than that reported with an equal dose of testosterone enanthate, and is in agreement with earlier studies showing a slightly stronger negative impact on HDL/LDL ratio with nandrolone decanoate as compared to testosterone cypionate.479 Nandrolone should still have a significantly weaker impact on serum lipids than c-17 alpha alkylated agents. Anabolic/androgenic steroids may also adversely effect blood pressure and triglycerides, reduce endothelial relaxation, and support left ventricular hypertrophy, all potentially increasing the risk of cardiovascular disease and myocardial infarction. To help reduce cardiovascular strain it is advised to maintain an active cardiovascular exercise program and minimize the intake of saturated fats, cholesterol, and simple carbohydrates at all times during active AAS administration. Supplementing with fish oils (4 grams per day) and a natural cholesterol/antioxidant formula such as Lipid Stabil or a product with comparable ingredients is also recommended.

5 - Testosterone Suppression issue:

All anabolic/androgenic steroids when taken in doses sufficient to promote muscle gain are expected to suppress endogenous testosterone production. Studies administering 100 mg injection of nandrolone phenylpropionate demonstrated a rapid suppression of serum testosterone following a single injection. Testosterone levels declined to approximately 30% of initial level by day 3 after drug administration, and stayed suppressed for approximately 13 days. Regular use is expected to significantly lengthen the endogenous hormone recovery window. It is believed that the progestational activity of nandrolone notably contributes to the suppression of testosterone synthesis during therapy, which can be marked in spite of a low tendency for estrogen conversion.480 Without the intervention of testosteronestimulating substances, testosterone levels should return to normal within 2-6 months of drug secession. Note that prolonged hypogonadotrophic hypogonadism can develop secondary to steroid abuse, necessitating medical intervention.

Nandrolone Phenylpropionate Dose:

Male:

For general anabolic effects, early prescribing guidelines recommend a dosage of 25-50 mg per week for 12 weeks. The usual dosage for physique- or performance-enhancing purposes is in the range of 200-400 mg per week, taken in cycles 8 to 12 weeks in length. This level is sufficient for most users to notice measurable gains in lean muscle mass and strength. Note that due to the fast acting nature of the phenylpropionate ester, the weekly dosage is usually subdivided into 2 separate applications spaced evenly apart.

Female:

For general anabolic effects, early prescribing guidelines recommend a dosage of 25-50 mg per week for 12 weeks. When used for physique- or performance-enhancing purposes, a dosage of 50 mg per week (given in a single weekly injection) is most common, taken for cycle lasting 4 to 6 weeks. Higher doses or longer durations of use are discouraged due to potential for androgenic side effects. Although only slightly androgenic, women are occasionally confronted with virilization symptoms when taking this compound. Should virilizing side effects become a concern, nandrolone phenylpropionate should be discontinued immediately to help prevent a permanent appearance.

Nandrolone Phenylpropionate (NPP) Cycle:

is a shorter-acting ester of nandrolone, similar to Nandrolone Decanoate (Deca Durabolin) but with a shorter half-life. Due to its shorter half-life, NPP requires more frequent injections to maintain stable blood levels. Here's a typical outline of a Nandrolone Phenylpropionate cycle:

Cycle Length: 6-8 weeks

Dosage:

• Beginner: 200-300mg per week (divided into 2-3 injections per week)
• Intermediate: 300-400mg per week (divided into 2-3 injections per week)
• Advanced: 400-600mg per week (divided into 2-3 injections per week)

NPP is often used in bulking cycles to promote muscle growth, increase strength, and aid in recovery. It can also be utilized in cutting cycles to help preserve lean muscle mass while dieting.

Nandrolone Phenylpropionate is commonly stacked with other steroids for enhanced results. It's frequently combined with testosterone and/or other compounds like Dianabol or Anadrol during bulking cycles.

Nandrolone Phenylpropionate Post-cycle therapy (PCT)

is typically recommended after completing a Nandrolone Phenylpropionate cycle to help restore natural testosterone production. This may involve the use of drugs like Clomid or Nolvadex.

It's important to be aware of the potential side effects of Nandrolone Phenylpropionate, which can include estrogenic effects such as water retention and gynecomastia, androgenic effects such as acne and hair loss, as well as cardiovascular issues and suppression of natural testosterone production. Therefore, it's crucial to use Nandrolone Phenylpropionate responsibly, under the guidance of a healthcare professional, and to follow proper post-cycle therapy protocols to mitigate any adverse effects and maintain overall health and well-being

Nandrolone Decanoate

Alternative Names:

Nortestosterone Decanoate,Nortestesterone Decylate

Proprietary Names:

Anaboline (50 mg./ml.),Anaboline LA-100,Deca-Durabol (25, 50, 100, 200 mg./ml.),Deca-ject (25, 50 mg./ml.),Elpihormo (50 mg./ml.),Extraboline (50 mg./ml.),Hyboline Decanoate (50, 100 mg./ml.),Jebolan (50 mg./ml.),Nandrolone Decanoate (50, 100, 200 mg./ml.),Nurezan (50 mg./ml.),Retabolil (25, 50 mg./ml.),Retabolin (50 mg./ml.),Turinabol Depot (50 mg./ml.),Ziremilon (50 mg./ml.)

Veterinary Products:

Anabolicum, Norandren

Therapeutic Dose:

50 mg. every 3 weeks (osteoporosis in postmenopausal women)

50 – 100 mg. weekly (aplastic anemia)

Nandrolone Decanoate in the form of the Organon product, Deca-Duraboline has been around for over thirty years, it has anabolic, androgenic, progestogenic and erythropoietic activity. The steroid maintains the anabolic activity of testosterone, but the androgenic action is markedly diminished. The anabolic/androgenic quotient after 2 weeks treatment has been shown to be 12 times of that obtained with testosterone decanoate.

Nandrolone Decanoate Benefit:

1 - Nandrolone Decanoate has been shown to positively influence calcium metabolism and to increase bone mass. In osteoporosis. Androgenic effects are relatively uncommon at the recommended therapeutic dosages.

2 - As Nandrolone is not C 17 alpha-alkylated It does not have as strong an association with the occurrence of liver dysfunction and cholestasis. However, it may cause fluid retention and oedema due to sodium retention by the kidney. Nandrolone decanoate is slowly released from the injection site into the blood with a half-life of 6 – 8 days. Nandrolone Decanoate has been used to treat a variety of disorders, including:

Osteoporosis in post-menopausal women,

Disseminated breast cancer in women,

Protein deficiency states occurring after major surgery or trauma,

Anemia,

Chronic renal failure

Nandrolone Decanoate Side Effect:

1 - Nandrolone decanoate is an injectable form of the anabolic steroid nandrolone. The decanoate ester provides a slow release of nandrolone from the site of injection, lasting for up to three weeks. Nandrolone is very similar to testosterone in structure, although it lacks a carbon atom at the 19th position (hence its other name, 19- nortestosterone). Like testosterone, nandrolone exhibits relatively strong anabolic properties. Unlike testosterone, however, its tissue-building activity is accompanied by weak androgenic properties. Much of this has to do with the reduction of nandrolone to a weaker steroid, dihydronandrolone, in the same androgen- responsive target tissues that potentate the action of testosterone (by converting it to DHT). The mild properties of nandrolone decanoate have made it one of the most popular injectable steroids worldwide, highly favored by athletes for its ability to promote significant strength and lean muscle mass gains without strong androgenic or estrogenic side effects.

2 - Nandrolone Decanoate (Deca) is widely considered to be the most used injectable anabolic steroid used for performance enhancement. It also has the reputation for being one of the most frequently detected banned substances (metabolites can be detected for periods more than one year). Because of its popularity Deca has been widely counterfeited. Due to its relatively low androgenic properties, it is also commonly thought to aromatise only at high doses. Deca is commonly used for ‘bulking-up’ and has a reputation for promoting size and strength. There have also been reports of Deca being effective in alleviating joint and tendon pains. Although some bodybuilders have found Deca effective during the pre-competition phase, others have found water retention to be a problem. Reports of side-effects include hypertension, acne, sexual and reproductive problems. The occurrence of side-effects appears to be more common in female and influenced strongly by the dosage used. The most common incidence of adverse effects includes facial hair growth, deepening of the voice and clitoral enlargement.

3 – Estrogenic issue:

Nandrolone has a low tendency for estrogen conversion, estimated to be only about 20% of that seen with testosterone.434 This is because while the liver can convert nandrolone to estradiol, in other more active sites of steroid aromatization such as adipose tissue nandrolone is far less open to this process.435 Consequently, estrogen-related side effects are a much lower concern with this drug than with testosterone. Elevated estrogen levels may still be noticed with higher dosing, however, and may cause side effects such as increased water retention, body fat gain, and gynecomastia. An anti-estrogen such as clomiphene citrate or tamoxifen citrate may be necessary to prevent estrogenic side effects if they occur. One may alternately use an aromatase inhibitor like Arimidex® (anastrozole), which more efficiently controls estrogen by preventing its synthesis. Aromatase inhibitors can be quite expensive in comparison to anti-estrogens, however, and may also have negative effects on blood lipids. It is of note that nandrolone has some activity as a progestin in the body.436 Although progesterone is a c-19 steroid, removal of this group as in 19-norprogesterone creates a hormone with greater binding affinity for its corresponding receptor. Sharing this trait, many 19-nor anabolic steroids are shown to have some affinity for the progesterone receptor as well.437 The side effects associated with progesterone are similar to those of estrogen, including negative feedback inhibition of testosterone production and enhanced rate of fat storage. Progestins also augment the stimulatory effect of estrogens on mammary tissue growth. There appears to be a strong synergy between these two hormones here, such that gynecomastia might even occur with the help of progestins, without excessive estrogen levels. The use of an antiestrogen, which inhibits the estrogenic component of this disorder, is often sufficient to mitigate gynecomastia caused by nandrolone.

4 – Androgenic issue:

Although classified as an anabolic steroid, androgenic side effects are still possible with this substance, especially with higher doses. This may include bouts of oily skin, acne, and body/facial hair growth. Anabolic/androgenic steroids may also aggravate male pattern hair loss. Women are warned of the potential virilizing effects of anabolic/androgenic steroids. These may include a deepening of the voice, menstrual irregularities, changes in skin texture, facial hair growth, and clitoral enlargement. Nandrolone is a steroid with relatively low androgenic activity relative to its tissuebuilding actions, making the threshold for strong androgenic side effects comparably higher than with more androgenic agents such as testosterone, methandrostenolone, or fluoxymesterone. It is also important to point out that due to its mild androgenic nature and ability to suppress endogenous testosterone, nandrolone is prone to interfering with libido in males when used without another androgen. Note that in androgen-responsive target tissues such as the skin, scalp, and prostate, the relative androgenicity of nandrolone is reduced by its reduction to dihydronandrolone (DHN).438 439 The 5-alpha reductase enzyme is responsible for this metabolism of nandrolone. The concurrent use of a 5- alpha reductase inhibitor such as finasteride or dutasteride will interfere with site-specific reduction of nandrolone action, considerably increasing the tendency of nandrolone to produce androgenic side effects. Reductase inhibitors should be avoided with nandrolone if low androgenicity is desired.

5 – Hepatotoxicity issue:

Nandrolone is not c-17 alpha alkylated, and not known to have hepatotoxic effects in healthy subjects. Liver toxicity is unlikely.

6 – Cardiovascular issue:

Anabolic/androgenic steroids can have deleterious effects on serum cholesterol. This includes a tendency to reduce HDL (good) cholesterol values and increase LDL (bad) cholesterol values, which may shift the HDL to LDL balance in a direction that favors greater risk of arteriosclerosis. The relative impact of an anabolic/androgenic steroid on serum lipids is dependant on the dose, route of administration (oral vs. injectable), type of steroid (aromatizable or nonaromatizable), and level of resistance to hepatic metabolism. Studies administering 600 mg of nandrolone decanoate per week for 10 weeks demonstrated a 26% reduction in HDL cholesterol levels.440 This suppression is slightly greater than that reported with an equal dose of testosterone enanthate, and is in agreement with earlier studies showing a slightly stronger negative impact on HDL/LDL ratio with nandrolone decanoate as compared to testosterone cypionate.441 Nandrolone decanoate should still have a significantly weaker impact on serum lipids than c-17 alpha alkylated agents. Anabolic/androgenic steroids may also adversely affect blood pressure and triglycerides, reduce endothelial relaxation, and support left ventricular hypertrophy, all potentially increasing the risk of cardiovascular disease and myocardial infarction. To help reduce cardiovascular strain it is advised to maintain an active cardiovascular exercise program and minimize the intake of saturated fats, cholesterol, and simple carbohydrates always during active AAS administration. Supplementing with fish oils (4 grams per day) and a natural cholesterol/antioxidant formula such as Lipid Stabil or a product with comparable ingredients is also recommended.

7 - Testosterone Suppression:

All anabolic/androgenic steroids, when taken in doses sufficient to promote muscle gain are expected to suppress endogenous testosterone production. Studies administering 100 mg per week of nandrolone decanoate for 6 weeks have demonstrated an approximate 57% reduction in serum testosterone levels during therapy. At a dosage of 300 mg per week, this reduction reached 70%.442 It is believed that the progestational activity of nandrolone notably contributes to the suppression of testosterone synthesis during therapy, which can be marked despite a low tendency for estrogen conversion.443 Without the intervention of testosteronestimulating substances, testosterone levels should return to normal within 2-6 months of drug secession. Note that prolonged hypogonadotrophic hypogonadism can develop secondary to steroid abuse, necessitating medical intervention.

Nandrolone Decanoate Dose:

Male: 200 – 400 mg. per week.

For general anabolic effects, early prescribing guidelines recommend a dosage of 50-100 mg every 3-4 weeks for 12 weeks. To treat renal anemia, the prescribing guidelines for nandrolone decanoate recommend a dosage of 100- 200 mg per week. The usual dosage for physique- or performanceenhancing purposes is the range of 200-600 mg per week, taken in cycles 8 to 12 weeks in length. This level is sufficient for most users to notice measurable gains in lean muscle mass and strength. It is often stated that nandrolone decanoate will exhibit its optimal effect (best gain/side effect ratio) at 2 mg per pound of bodyweight/weekly, although individual differences in response will likely dictate varying ideal doses for different users. Deca is not known as a very “fast” builder. The muscle-building effect of this drug is quite noticeable, but not dramatic. In general, one can expect to gain muscle weight at about half the rate of that with an equal amount of testosterone. Nandrolone decanoate is often combined with other steroids for an enhanced effect. A combination of 200-400 mg/week of nandrolone decanoate and 10-20 mg daily of Stanozolol, for example, is noted to greatly enhance the look of muscularity and definition when dieting/cutting. A strong non-aromatizing androgen like Fluoxymetholone or trenbolone could also be used, again providing an enhanced level of hardness and density to the muscles. Being a moderately strong muscle builder, nandrolone can also be incorporated into bulk cycles with acceptable results. The classic “Deca and D-bol” stack (usually 200-400 mg of nandrolone decanoate per week and 15-25 mg of Dianabol per day) has been a bodybuilding basic for decades, and always seems to provide excellent muscle growth. A stronger androgen such as Anadrol 50® or testosterone could also be substituted, producing greater results, but with more water retention.

Female: 50 – 100 mg. per week.

For general anabolic effects, early prescribing guidelines recommend a dosage of 50-100 mg every 3-4 weeks for 12 weeks. To treat renal anemia, the prescribing guidelines for nandrolone decanoate recommend a dosage of 50-100 mg per week. When used for physique- or performance-enhancing purposes, a dosage of 50 mg per week is most common, taken for 4-6 weeks. Although only slightly androgenic, women are occasionally confronted with virilization symptoms when taking this compound. Studies have demonstrated high tolerability (minor but statistically insignificant incidence of virilizing side effects) with a dose of 100 mg every other week for 12 weeks,444 while longterm studies ( 12 months of use) have demonstrated virilizing side effects on a dose as low as 50 mg every 2-3 weeks.445 Should virilizing side effects become a concern, nandrolone decanoate should be discontinued immediately to help prevent their permanent appearance. After a sufficient period of withdrawal, the shorter-acting nandrolone Durabolin® might be considered a safer option. This drug stays active for only several days, greatly reducing the withdrawal time if indicated.

Nandrolone Decanoate Cycle:

commonly known as Deca Durabolin, is an injectable anabolic steroid derived from testosterone. It is valued in the bodybuilding and athletic communities for its ability to promote muscle growth, increase strength, and aid in recovery.

Here's a typical outline of a Nandrolone Decanoate cycle:

Cycle Length: 10-12 weeks (some may extend to 14 weeks, but longer cycles increase the risk of side effects)

Dosage:

• Beginner: 200-300mg per week
• Intermediate: 300-400mg per week
• Advanced: 400-600mg per week

Nandrolone Decanoate has a long half-life, so it can be injected once a week. Some users prefer to split the dosage into two injections per week to maintain stable blood levels.

Nandrolone Decanoate is often used in combination with other steroids for enhanced results. It's commonly stacked with testosterone and/or other compounds like Dianabol or Anadrol during bulking cycles.

Nandrolone Decanoate Post-cycle therapy (PCT)

is typically recommended after completing a Nandrolone Decanoate cycle to help restore natural testosterone production. This may involve the use of drugs like Clomid or Nolvadex.

It's important to be aware of the potential side effects of Nandrolone Decanoate, including but not limited to estrogenic effects such as water retention and gynecomastia, androgenic effects such as acne and hair loss, as well as cardiovascular issues and suppression of natural testosterone production. Therefore, it's crucial to use Nandrolone Decanoate responsibly, under the guidance of a healthcare professional, and to follow proper post-cycle therapy protocols to mitigate any adverse effects and maintain overall health and well-being

Nandrolone Decanoate

Alternative Names:

Nortestosterone Decanoate,Nortestesterone Decylate

Proprietary Names:

Anaboline (50 mg./ml.),Anaboline LA-100,Deca-Durabol (25, 50, 100, 200 mg./ml.),Deca-ject (25, 50 mg./ml.),Elpihormo (50 mg./ml.),Extraboline (50 mg./ml.),Hyboline Decanoate (50, 100 mg./ml.),Jebolan (50 mg./ml.),Nandrolone Decanoate (50, 100, 200 mg./ml.),Nurezan (50 mg./ml.),Retabolil (25, 50 mg./ml.),Retabolin (50 mg./ml.),Turinabol Depot (50 mg./ml.),Ziremilon (50 mg./ml.)

Veterinary Products:

Anabolicum, Norandren

Therapeutic Dose:

50 mg. every 3 weeks (osteoporosis in postmenopausal women)

50 – 100 mg. weekly (aplastic anemia)

Nandrolone Decanoate in the form of the Organon product, Deca-Duraboline has been around for over thirty years, it has anabolic, androgenic, progestogenic and erythropoietic activity. The steroid maintains the anabolic activity of testosterone, but the androgenic action is markedly diminished. The anabolic/androgenic quotient after 2 weeks treatment has been shown to be 12 times of that obtained with testosterone decanoate.

Nandrolone Decanoate Benefit:

1 - Nandrolone Decanoate has been shown to positively influence calcium metabolism and to increase bone mass. In osteoporosis. Androgenic effects are relatively uncommon at the recommended therapeutic dosages.

2 - As Nandrolone is not C 17 alpha-alkylated It does not have as strong an association with the occurrence of liver dysfunction and cholestasis. However, it may cause fluid retention and oedema due to sodium retention by the kidney. Nandrolone decanoate is slowly released from the injection site into the blood with a half-life of 6 – 8 days. Nandrolone Decanoate has been used to treat a variety of disorders, including:

Osteoporosis in post-menopausal women,

Disseminated breast cancer in women,

Protein deficiency states occurring after major surgery or trauma,

Anemia,

Chronic renal failure

Nandrolone Decanoate Side Effect:

1 - Nandrolone decanoate is an injectable form of the anabolic steroid nandrolone. The decanoate ester provides a slow release of nandrolone from the site of injection, lasting for up to three weeks. Nandrolone is very similar to testosterone in structure, although it lacks a carbon atom at the 19th position (hence its other name, 19- nortestosterone). Like testosterone, nandrolone exhibits relatively strong anabolic properties. Unlike testosterone, however, its tissue-building activity is accompanied by weak androgenic properties. Much of this has to do with the reduction of nandrolone to a weaker steroid, dihydronandrolone, in the same androgen- responsive target tissues that potentate the action of testosterone (by converting it to DHT). The mild properties of nandrolone decanoate have made it one of the most popular injectable steroids worldwide, highly favored by athletes for its ability to promote significant strength and lean muscle mass gains without strong androgenic or estrogenic side effects.

2 - Nandrolone Decanoate (Deca) is widely considered to be the most used injectable anabolic steroid used for performance enhancement. It also has the reputation for being one of the most frequently detected banned substances (metabolites can be detected for periods more than one year). Because of its popularity Deca has been widely counterfeited. Due to its relatively low androgenic properties, it is also commonly thought to aromatise only at high doses. Deca is commonly used for ‘bulking-up’ and has a reputation for promoting size and strength. There have also been reports of Deca being effective in alleviating joint and tendon pains. Although some bodybuilders have found Deca effective during the pre-competition phase, others have found water retention to be a problem. Reports of side-effects include hypertension, acne, sexual and reproductive problems. The occurrence of side-effects appears to be more common in female and influenced strongly by the dosage used. The most common incidence of adverse effects includes facial hair growth, deepening of the voice and clitoral enlargement.

3 – Estrogenic issue:

Nandrolone has a low tendency for estrogen conversion, estimated to be only about 20% of that seen with testosterone.434 This is because while the liver can convert nandrolone to estradiol, in other more active sites of steroid aromatization such as adipose tissue nandrolone is far less open to this process.435 Consequently, estrogen-related side effects are a much lower concern with this drug than with testosterone. Elevated estrogen levels may still be noticed with higher dosing, however, and may cause side effects such as increased water retention, body fat gain, and gynecomastia. An anti-estrogen such as clomiphene citrate or tamoxifen citrate may be necessary to prevent estrogenic side effects if they occur. One may alternately use an aromatase inhibitor like Arimidex® (anastrozole), which more efficiently controls estrogen by preventing its synthesis. Aromatase inhibitors can be quite expensive in comparison to anti-estrogens, however, and may also have negative effects on blood lipids. It is of note that nandrolone has some activity as a progestin in the body.436 Although progesterone is a c-19 steroid, removal of this group as in 19-norprogesterone creates a hormone with greater binding affinity for its corresponding receptor. Sharing this trait, many 19-nor anabolic steroids are shown to have some affinity for the progesterone receptor as well.437 The side effects associated with progesterone are similar to those of estrogen, including negative feedback inhibition of testosterone production and enhanced rate of fat storage. Progestins also augment the stimulatory effect of estrogens on mammary tissue growth. There appears to be a strong synergy between these two hormones here, such that gynecomastia might even occur with the help of progestins, without excessive estrogen levels. The use of an antiestrogen, which inhibits the estrogenic component of this disorder, is often sufficient to mitigate gynecomastia caused by nandrolone.

4 – Androgenic issue:

Although classified as an anabolic steroid, androgenic side effects are still possible with this substance, especially with higher doses. This may include bouts of oily skin, acne, and body/facial hair growth. Anabolic/androgenic steroids may also aggravate male pattern hair loss. Women are warned of the potential virilizing effects of anabolic/androgenic steroids. These may include a deepening of the voice, menstrual irregularities, changes in skin texture, facial hair growth, and clitoral enlargement. Nandrolone is a steroid with relatively low androgenic activity relative to its tissuebuilding actions, making the threshold for strong androgenic side effects comparably higher than with more androgenic agents such as testosterone, methandrostenolone, or fluoxymesterone. It is also important to point out that due to its mild androgenic nature and ability to suppress endogenous testosterone, nandrolone is prone to interfering with libido in males when used without another androgen. Note that in androgen-responsive target tissues such as the skin, scalp, and prostate, the relative androgenicity of nandrolone is reduced by its reduction to dihydronandrolone (DHN).438 439 The 5-alpha reductase enzyme is responsible for this metabolism of nandrolone. The concurrent use of a 5- alpha reductase inhibitor such as finasteride or dutasteride will interfere with site-specific reduction of nandrolone action, considerably increasing the tendency of nandrolone to produce androgenic side effects. Reductase inhibitors should be avoided with nandrolone if low androgenicity is desired.

5 – Hepatotoxicity issue:

Nandrolone is not c-17 alpha alkylated, and not known to have hepatotoxic effects in healthy subjects. Liver toxicity is unlikely.

6 – Cardiovascular issue:

Anabolic/androgenic steroids can have deleterious effects on serum cholesterol. This includes a tendency to reduce HDL (good) cholesterol values and increase LDL (bad) cholesterol values, which may shift the HDL to LDL balance in a direction that favors greater risk of arteriosclerosis. The relative impact of an anabolic/androgenic steroid on serum lipids is dependant on the dose, route of administration (oral vs. injectable), type of steroid (aromatizable or nonaromatizable), and level of resistance to hepatic metabolism. Studies administering 600 mg of nandrolone decanoate per week for 10 weeks demonstrated a 26% reduction in HDL cholesterol levels.440 This suppression is slightly greater than that reported with an equal dose of testosterone enanthate, and is in agreement with earlier studies showing a slightly stronger negative impact on HDL/LDL ratio with nandrolone decanoate as compared to testosterone cypionate.441 Nandrolone decanoate should still have a significantly weaker impact on serum lipids than c-17 alpha alkylated agents. Anabolic/androgenic steroids may also adversely affect blood pressure and triglycerides, reduce endothelial relaxation, and support left ventricular hypertrophy, all potentially increasing the risk of cardiovascular disease and myocardial infarction. To help reduce cardiovascular strain it is advised to maintain an active cardiovascular exercise program and minimize the intake of saturated fats, cholesterol, and simple carbohydrates always during active AAS administration. Supplementing with fish oils (4 grams per day) and a natural cholesterol/antioxidant formula such as Lipid Stabil or a product with comparable ingredients is also recommended.

7 - Testosterone Suppression:

All anabolic/androgenic steroids, when taken in doses sufficient to promote muscle gain are expected to suppress endogenous testosterone production. Studies administering 100 mg per week of nandrolone decanoate for 6 weeks have demonstrated an approximate 57% reduction in serum testosterone levels during therapy. At a dosage of 300 mg per week, this reduction reached 70%.442 It is believed that the progestational activity of nandrolone notably contributes to the suppression of testosterone synthesis during therapy, which can be marked despite a low tendency for estrogen conversion.443 Without the intervention of testosteronestimulating substances, testosterone levels should return to normal within 2-6 months of drug secession. Note that prolonged hypogonadotrophic hypogonadism can develop secondary to steroid abuse, necessitating medical intervention.

Nandrolone Decanoate Dose:

Male: 200 – 400 mg. per week.

For general anabolic effects, early prescribing guidelines recommend a dosage of 50-100 mg every 3-4 weeks for 12 weeks. To treat renal anemia, the prescribing guidelines for nandrolone decanoate recommend a dosage of 100- 200 mg per week. The usual dosage for physique- or performanceenhancing purposes is the range of 200-600 mg per week, taken in cycles 8 to 12 weeks in length. This level is sufficient for most users to notice measurable gains in lean muscle mass and strength. It is often stated that nandrolone decanoate will exhibit its optimal effect (best gain/side effect ratio) at 2 mg per pound of bodyweight/weekly, although individual differences in response will likely dictate varying ideal doses for different users. Deca is not known as a very “fast” builder. The muscle-building effect of this drug is quite noticeable, but not dramatic. In general, one can expect to gain muscle weight at about half the rate of that with an equal amount of testosterone. Nandrolone decanoate is often combined with other steroids for an enhanced effect. A combination of 200-400 mg/week of nandrolone decanoate and 10-20 mg daily of Stanozolol, for example, is noted to greatly enhance the look of muscularity and definition when dieting/cutting. A strong non-aromatizing androgen like Fluoxymetholone or trenbolone could also be used, again providing an enhanced level of hardness and density to the muscles. Being a moderately strong muscle builder, nandrolone can also be incorporated into bulk cycles with acceptable results. The classic “Deca and D-bol” stack (usually 200-400 mg of nandrolone decanoate per week and 15-25 mg of Dianabol per day) has been a bodybuilding basic for decades, and always seems to provide excellent muscle growth. A stronger androgen such as Anadrol 50® or testosterone could also be substituted, producing greater results, but with more water retention.

Female: 50 – 100 mg. per week.

For general anabolic effects, early prescribing guidelines recommend a dosage of 50-100 mg every 3-4 weeks for 12 weeks. To treat renal anemia, the prescribing guidelines for nandrolone decanoate recommend a dosage of 50-100 mg per week. When used for physique- or performance-enhancing purposes, a dosage of 50 mg per week is most common, taken for 4-6 weeks. Although only slightly androgenic, women are occasionally confronted with virilization symptoms when taking this compound. Studies have demonstrated high tolerability (minor but statistically insignificant incidence of virilizing side effects) with a dose of 100 mg every other week for 12 weeks,444 while longterm studies ( 12 months of use) have demonstrated virilizing side effects on a dose as low as 50 mg every 2-3 weeks.445 Should virilizing side effects become a concern, nandrolone decanoate should be discontinued immediately to help prevent their permanent appearance. After a sufficient period of withdrawal, the shorter-acting nandrolone Durabolin® might be considered a safer option. This drug stays active for only several days, greatly reducing the withdrawal time if indicated.

Nandrolone Decanoate Cycle:

commonly known as Deca Durabolin, is an injectable anabolic steroid derived from testosterone. It is valued in the bodybuilding and athletic communities for its ability to promote muscle growth, increase strength, and aid in recovery.

Here's a typical outline of a Nandrolone Decanoate cycle:

Cycle Length: 10-12 weeks (some may extend to 14 weeks, but longer cycles increase the risk of side effects)

Dosage:

• Beginner: 200-300mg per week
• Intermediate: 300-400mg per week
• Advanced: 400-600mg per week

Nandrolone Decanoate has a long half-life, so it can be injected once a week. Some users prefer to split the dosage into two injections per week to maintain stable blood levels.

Nandrolone Decanoate is often used in combination with other steroids for enhanced results. It's commonly stacked with testosterone and/or other compounds like Dianabol or Anadrol during bulking cycles.

Nandrolone Decanoate Post-cycle therapy (PCT)

is typically recommended after completing a Nandrolone Decanoate cycle to help restore natural testosterone production. This may involve the use of drugs like Clomid or Nolvadex.

It's important to be aware of the potential side effects of Nandrolone Decanoate, including but not limited to estrogenic effects such as water retention and gynecomastia, androgenic effects such as acne and hair loss, as well as cardiovascular issues and suppression of natural testosterone production. Therefore, it's crucial to use Nandrolone Decanoate responsibly, under the guidance of a healthcare professional, and to follow proper post-cycle therapy protocols to mitigate any adverse effects and maintain overall health and well-being

MK-677, also known as Ibutamoren, is a growth hormone secretagogue (GHS) that stimulates the secretion of growth hormone (GH) and insulin-like growth factor 1 (IGF-1) in the body. Unlike traditional growth hormone (GH) therapy, which involves injections of synthetic GH, MK-677 works by increasing the natural production of GH and IGF-1.

MK-677 achieves this by binding to ghrelin receptors in the brain, which triggers the release of growth hormone from the pituitary gland. This mechanism of action makes MK-677 particularly appealing for its potential to increase lean body mass, improve bone density, and promote muscle growth without the need for exogenous growth hormone injections.

In addition to its effects on muscle growth and body composition, MK-677 has been studied for its potential therapeutic benefits in a variety of conditions, including growth hormone deficiency, sarcopenia (age-related muscle loss), osteoporosis, and wasting syndromes associated with chronic illnesses.

MK-677 is typically taken orally in the form of capsules or liquid. It is often used in cycles, with users typically taking it for several weeks to months, followed by a period of rest. It is important to note that MK-677 is not approved for human use by regulatory agencies such as the FDA, and its long-term effects on health are not well understood.

Like all medications, MK-677 may cause side effects. Common side effects may include increased appetite, water retention, fatigue, and transient increases in blood sugar levels. It may also interact with other medications or supplements, so it's essential to use MK-677 under the supervision of a healthcare provider experienced in its use.

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IBUTAMOREN (MK-677)

Structure Characteristic:

2-amino-2-methyl-N-[(2R)-1-(1-methylsulfonylspiro[2H-indole-3,4'-piperidine]-1'-yl)-1-oxo-3- phenylmethoxypropan-2-yl]propenamide

HALF-LIFE:

24 Hours

DOSE:

10 - 20 mg.-day

CYCLE LENGTH:

8 - 16 weeks

Description:

Ibutamoren (also known as MK-677 and Oratrope) is an oral Growth Hormone Secretagogue and an agonist of the Ghrelin Receptor. It was developed by Reverse Pharmacology for the treatment of growth hormone deficiency, muscle wasting conditions and osteoporosis.

This is an extremely popular compound used as a replacement for regular HGH injections. It is not as powerful as elevated doses of HGH, but it is way cheaper, rarely faked and orally bioavailable. It also has some properties that make it a very interesting, unique and versatile drug.

Benefit:

1 - MUSCLE Even though Ibutamoren will increase IGF-1, one of the most anabolic hormones in our bodies, it will not accrue a significant amount of muscle mass on its own. It will, however, amplify the effects of actual anabolics like SARMs or steroids if you choose to stack it with those. Furthermore, Ibutamoren has been proven to be anticatabolic, so it will help preserve muscle on a caloric deficit. Growth Hormone (and thus Ibutamoren) helps everything work better, but it will not add much muscle on its own.

2 - STRENGTH AND PERFORMANCE Ibutamoren is known for increasing water retention, which often helps improve strength. The positive effect of high HGH on the joints and tendons will also help you become stronger and perform better.

3 - FAT LOSS Growth Hormone is known for boosting fat loss, so Ibutamoren will indeed help you burn fat. Unfortunately, it will make you a lot hungrier, so not overeating may prove to be difficult and it could stop you from losing weight.

4 - BONES AND JOINTS As previously mentioned, having elevated levels of Growth Hormone will not only strengthen bones, but it will also heal, repair, and strengthen your joints, ligaments and tendons. For this reason, one will be less likely to get injured in the gym. Many people claim that Ibutamoren has fixed chronic pain in some areas of their body, and it will definitely boost the speed at which your body heals itself (whether it be skin damage, skin burns, bone fractures, injured joints, etc…)

5 - RECOVERY Since HGH speeds up tissue healing and regeneration, one can expect faster muscle recovery when taking Ibutamoren. This means you will feel less sore and you will be read to work out again sooner.

6 - INCREASED HUNGER This can be an undesired side-effect of Ibutamoren but being more hungry during a bulk will help you eat enough to keep growing. Bodybuilders who struggle to gain weight due to lack of hunger benefit greatly from this property.

Some people report having no extra hunger when they take Ibutamoren before bed, so if you want to benefit from the increased hunger, take Ibutamoren first thing in the morning.

7 - BETTER SLEEP One of the best things about Ibutamoren is that it makes sleep better. It causes deeper and longer REM sleep and helps you feel more refreshed and energized the next day. According to some people, 6 hours of sleep on Ibutamoren are as effective, refreshing and energizing as 8 hours of normal sleep. Another great thing about better sleep is that it will help you recover faster and gain more muscle in the long run, as well as improve your hormonal levels.

8 - COSMETIC BENEFITS The added water retention helps fill out the muscles and makes them look bigger. Gains of up to 10lbs in water retention are possible. Unfortunately, the drawback of water retention is that you will look puffy and bloated, but if you are already very lean, the extra water weight can make you look fuller and more pumped. Having extra growth hormone will also make your skin and hair look younger and healthier.

— Efficiently helps to increase GH and IGF1 levels.

— Improves sleep quality.

Side-Effects:

1 - INSULIN SENSITIVITY AND BLOOD SUGAR LEVELS It was found in clinical studies that Ibutamoren can decrease insulin sensitivity and increase blood sugar levels. For this reason, taking Ibutamoren at high doses for prolonged periods of time while having an elevated carb intake can potentially cause Diabetes. Thankfully this side-effect can be mitigated and avoided completely. (More information in the chapter about On-Cycle Therapy).

2 - WATER RETENTION Even though the water retention can be useful when it comes to looking bigger, getting stronger and protecting your joints, it is an undesired effect for some people Firstly, it can make your muscles blurry and less defined if you are not extremely lean to begin with, and it will make your face chubby and round, therefore making you less attractive. Secondly, if the water retention becomes too heavy (due to taking a very high dose or eating insane amounts of carbs), it can have a negative impact on the joints. And finally, excessive water retention can cause high blood pressure.

3 - LETHARGY Some users report feeling lethargic throughout the day if they take more than 15mg/day.

4 - CANCER Ibutamoren will NOT cause cancer. However, if a user already has cancer (whether he is aware of it or not), Ibutamoren will speed up the growth and development of his cancer cells.

5 - OTHER SIDE-EFFECTS The increased hunger be a negative side-effect for those who are trying to lose weight. Fortunately, it can be mitigated by taking the compound before bed instead of taking it in the morning. Another possible side-effect of Ibutamoren is growth of hands, feet, nose and other parts of the body due to having elevated levels of Growth Hormone, but one would have to take Ibutamoren for years on end for that to happen. Prolactin-induced erectile dysfunction, low libido and gynecomastia can happen, but they are extremely rare. Take Vitamin B6 to keep prolactin in check and avoid these sideeffects.

Enobosarm (ostarine, GTx-024, MK-2866, S-22)

Structure Characteristic:

(2S)-3-(4-cyanophenoxy)-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide

HALF-LIFE: 24 Hours

DOSE: 10 – 25 mg/day

CYCLE LENGTH: 8 – 12 weeks

Description:

Ostarine was one of the first SARMs ever created and the most popular one in the market today. It was developed by GTx, Inc. for the treatment of muscle wasting conditions and osteoporosis.

Benefit:

1 - MUSCLE

Ostarine will definitely increase your muscle mass. You can expect gains of up to 4-5 pounds of lean muscle gains in 8 to 12 weeks, while eating on a caloric surplus. With proper training and nutrition, you can even gain 1 to 2 pounds of lean muscle mass while on a caloric deficit. This makes Ostarine an excellent cutting compound.

2 - STRENGTH AND PERFORMANCE

Ostarine will increase your strength considerably if you are on a caloric surplus. On a caloric deficit, your strength will increasse during the first few weeks of the cycle, but it will then plateau as you start losing a significant amount of weight. Users often report increased stamina in the gym, which translates into shorter resting times between sets, more reps, and the ability to train longer than they are used to.

3 - FAT LOSS

Contrary to what some people believe, Ostarine will not help you lose more fat. It is not a fat burner by any means. SARMs ARE NOT APPROVED FOR HUMAN CONSUMPTION. THIS IS NOT MEDICAL ADVICE. 8 However, it will help retain and even gain muscle mass during a cut, making cutting cycles more effective and allowing you to lose fat without sacrificing your hard-earned gains.

4 - BONES AND JOINTS

Ostarine will increase the density and strength of your bones. This has been proven to be true in clinical studies and it is one of the purposes it was designed for in the first place. It is often claimed that Ostarine helps strengthen and heal joints and tendons. While there is not any clinical evidence to prove that this is true, anecdotal reports suggest that Ostarine can indeed strengthen joints and tendons.

5 - RECOVERY

Ostarine will make your recovery faster. You will feel less sore the next day and your muscles will be ready to work out again sooner.

6 - COSMETIC BENEFITS

Ostarine will not cause any extra water retention and it will significantly harden your muscles, giving them a lean and dense look. Users often claim that Ostarine makes their muscles pop more. It will also make your pumps more pronounced.

Side Effect:

1 - TESTOSTERONE SUPPRESSION

Ostarine, like all SARMs, will cause a significant drop in your Testosterone levels. Fortunately, it is one of the least suppressive SARMs out there and this side effect is very manageable and easily reversible. The consequences of this drop in your testosterone levels can be: - Decreased libido - Weaker erections - Lethargy - Lack of motivation - Irritability - Testicular atrophy - Testicular pain Thankfully, the vast majority of users do not experience more than a couple of these and only for a very limited amount of time, usually by the end of the cycle and during the first week or two after the cycle is over. It is also worth noting that Ostarine, like all SARMs, will decrease your SHBG. This will lead to an increase in your free testosterone levels which may cause libido, motivation and well-being to improve during the first few weeks of the cycle, until the suppression of the Total Testosterone levels offsets the increase in Free Testosterone.

2 - CHOLESTEROL

Ostarine, like all SARMs, will mess with your HDL and LDL cholesterol levels. Your HDL (good) cholesterol will be significantly decreased and your LDL (bad) cholesterol will probably increase. There is some evidence indicating that your LDL levels could actually decrease during the cycle, but there is evidence pointing the other way as well. This side-effect will not manifest itself by impacting the way you feel, so you will have no symptoms. Getting bloodwork at the end of a cycle will show the true impact of the SARM on your lipid panel.

3 - OTHER SIDE-EFFECTS

The two side effects we just touched upon will impact every user, but there are some side effects that only happen to an extremely small minority of people. For example:

Gynecomastia:

The growth of breast tissue on males. This is an extremely rare side effect that is caused by an imbalance between your estrogen and testosterone levels. Men who have had pubertal gynecomastia are at risk of developing it if they take Ostarine.

Hair shedding:

This side effect is even rarer than the previous one, and thankfully it only seems to be temporary and completely reversible. Any substance that interferes with your hormonal levels has the potential of causing hair shedding, and Ostarine is no exception.

Insomnia:

This is another rare side-effect that some people experience. This one is entirely unpredictable but can be mitigated easily.

— Worsening of the liver profile (proven in studies and with bloodwork), this is because SARMs cause liver stress, although to a much lesser extent than conventional oral steroids.

— Libido problems (anecdotally proven), this is due to the inhibition of the hormonal axis and the reduction of endogenous testosterone production.

— Inhibition of the axis (proven in studies and with bloodwork).

— Acne (anecdotally proven).

— Water retention (anecdotally proven), as said before, this cannot happen unless there is an underlying problem, due to the product being contaminated or it is a placebo effect.

Methyltrienolone

Description:

Methyltrienolone, commonly known as methyl trenbolone or MT, is a synthetic androgenic-anabolic steroid (AAS) that is derived from trenbolone, which itself is a modified form of nandrolone (a testosterone derivative). Methyltrienolone is considered one of the most potent and toxic AAS available due to its extremely high anabolic and androgenic activity.

Benefit:

1. Potency: Methyltrienolone is one of the most potent AAS ever synthesized. It has an anabolic rating that is several times greater than testosterone and even higher than that of its parent compound, trenbolone. Additionally, its androgenic potency is also significantly elevated, making it a very powerful steroid in terms of muscle-building effects.
2. Chemical Modification: Methyltrienolone is trenbolone with a methyl group attached at the 17th carbon position, which increases its oral bioavailability and resistance to metabolism. This modification enhances its potency but also increases its hepatotoxicity (liver toxicity).

Side Effect:

1. Medical Use: Methyltrienolone has never been approved for medical use in humans. It was initially developed for veterinary purposes, particularly for use in livestock to promote muscle growth and increase feed efficiency. However, due to its extreme potency and associated risks, it has never been approved for human use.
2. Side Effects: Methyltrienolone is associated with a range of side effects, including those commonly observed with AAS use, such as suppression of natural testosterone production, liver toxicity, cardiovascular effects, and androgenic side effects like acne, hair loss, and virilization in females. Additionally, due to its high potency, the risk of adverse effects is heightened compared to other steroids.
3. Legal Status: Methyltrienolone is classified as a controlled substance in many countries due to its potential for abuse and misuse. It is often regulated as a Schedule III controlled substance in the United States under the Controlled Substances Act.

Due to its extreme potency and associated risks, methyltrienolone is not recommended for use by athletes, bodybuilders, or individuals seeking to enhance physical performance. Its use is also discouraged in medical settings due to safety concerns. Anyone considering the use of methyltrienolone or any other AAS should carefully weigh the potential benefits against the risks and should consult with a qualified healthcare provider.

Methasterone

Description:

Methasterone, also known as methyldrostanolone or Superdrol, is a synthetic androgenic-anabolic steroid (AAS) that belongs to the class of compounds known as 17α-alkylated AAS. It was developed for medical use but has never been approved for human use due to safety concerns. Instead, it gained popularity as a performance-enhancing drug and was sold as a dietary supplement under various brand names.

Benefit:

1. Anabolic Effects: Methasterone exhibits strong anabolic properties, promoting muscle growth, strength gains, and improvements in physical performance. It is known for its high anabolic potency, with effects comparable to or greater than those of other AAS like testosterone or nandrolone.
2. Androgenic Effects: Methasterone also has androgenic effects, contributing to its ability to enhance masculine characteristics such as facial hair growth and deepening of the voice. However, it generally has a lower androgenic potency compared to testosterone.
3. Chemical Structure: Methasterone is derived from dihydrotestosterone (DHT) and is a modified form of drostanolone (Masteron), with a methyl group attached at the 17th carbon position. This modification increases its oral bioavailability and resistance to metabolism, making it suitable for oral administration.
4. Medical Use: Methasterone was initially developed for medical use, primarily for the treatment of conditions such as wasting syndromes, muscle wasting diseases, and osteoporosis. However, it was never approved for human use due to safety concerns, including hepatotoxicity (liver toxicity) and potential for abuse.

Side Effect:

1. Side Effects: Methasterone is associated with a range of side effects, similar to other AAS. These may include suppression of natural testosterone production, liver toxicity, cardiovascular effects, and androgenic side effects such as acne, hair loss, and virilization in females. Additionally, due to its high potency, the risk of adverse effects is heightened compared to other steroids.
2. Legal Status: Methasterone is classified as a controlled substance in many countries due to its potential for abuse and misuse. It is often regulated as a Schedule III controlled substance in the United States under the Controlled Substances Act.

Due to its safety concerns and potential for abuse, methasterone is not recommended for use by athletes, bodybuilders, or individuals seeking to enhance physical performance. Its use is also discouraged in medical settings due to safety concerns. Anyone considering the use of methasterone or any other AAS should carefully weigh the potential benefits against the risks and should consult with a qualified healthcare provider

Methenolone Enanthate

Description:

Methenolone Enanthate is an injectable version of the steroid methenolone. This is the same constituent in Primobolan® orals (methenolone acetate), although here an enanthate ester is used to slow the steroid’s release from a site of injection. Methenolone enanthate offers a similar pattern of steroid release as testosterone enanthate, with blood hormone levels remaining markedly elevated for approximately 2 weeks. Methenolone itself is a moderately strong anabolic steroid with very low androgenic properties. Its anabolic effect is considered to be slightly less than Deca-Durabolin® (nandrolone decanoate) on a milligram for milligram basis. Methenolone enanthate is most commonly used during cutting cycles, when lean mass gain, not a raw mass increase, is the main objective.

History:

Methenolone was first described in 1960.567 Squibb introduced the drug (as methenolone enanthate) to the U.S. prescription drug market in 1962,568 sold for a very short time in the U.S. under the brand name of Nibal® Depot. Rights to the drug were given to Schering in West Germany (now Bayer) that same year, and Nibal® Depot soon disappeared from the U.S. market. Schering would sell methenolone enanthate under its new and ultimately most recognizable brand name, Methenolone Enanthate. During the 1960s and ’70’s Methenolone Enanthate was available mainly in Europe, including such countries as Switzerland, Italy, Germany, Austria, Belgium, France, Portugal, and Greece. Schering maintained patent control over methenolone enanthate until the late 1970s. Before its patents expired, Schering had rigorously protected its intellectual property rights against any potential infringement, even in the U.S. market, where the company had not been marketing Methenolone Enanthate. Although methenolone enanthate has not been available for commercial sale in the United States for decades, it has technically retained its status as an FDA- approved drug. Methenolone Enanthate is typically prescribed as a lean tissue building anabolic agent, often used in cases where body wasting has occurred secondary to an operation, prolonged infection, wasting disease, aggressive corticosteroid administration, or convalescence. Some clinicians also prescribe this agent for treating osteoporosis, sarcopenia (the natural loss of muscle mass with aging), certain cases of chronic hepatitis, and breast carcinoma (usually as a secondary medication following other therapies). The steroid has also been used to promote weight gain in underweight premature infants and children in clinical studies, and was able to do so effectively and without signs of toxicity or undesirable effects.569 Athletes have long favored the combined strong anabolic, weak androgenic, and nonestrogenic nature of this drug, which makes it very desirable for building lean muscularity without side effects. Although Methenolone Enanthate demonstrated a good record of clinical safety, by the 1990s Schering had grown to be a multinational pharmaceutical giant, and was inevitably forced to reexamine its global steroid offerings in light of public concerns about sports doping. Methenolone Enanthate would be voluntarily withdrawn from most of the countries that had originally sold it. Today, the brand is sold in just a handful of countries including Spain, Turkey, Japan, Paraguay, and Ecuador. In spite of its limited supply, Bayer has remained (nearly) the exclusive producer of methenolone enanthate in the human drug business worldwide. In recent years, however, methenolone enanthate has shown up in a small number of other preparations, most from underground or export-only companies.

Methenolone Enanthate Structural Characteristics:

Methenolone is a derivative of dihydrotestosterone. It contains one additional double bond between carbons 1 and 2, which helps to stabilize the 3-keto group and increase the steroid’s anabolic properties, and an additional 1-methyl group, which gives the steroid some protection against hepatic metabolism. Methenolone Enanthate makes use of methenolone with a carboxylic acid ester (enanthoic acid) attached to the 17-beta hydroxyl group. Esterified steroids are less polar than free steroids, and are absorbed more slowly from the area of injection. Once in the bloodstream, the ester is removed to yield free (active) methenolone. Esterified steroids are designed to prolong the window of therapeutic effect following administration, allowing for a less frequent injection schedule compared to injections of free (unesterified) steroid.

Methenolone Enanthate Side Effect:

1 - Side Effects (Estrogenic):

Methenolone is not aromatized by the body,570 and is not measurably estrogenic. Estrogen-linked side effects should not be seen when administering this steroid. Sensitive individuals need not worry about developing gynecomastia, nor should they be noticing any appreciable water retention with this drug. The increase seen with methenolone should be quality muscle mass, not the smooth bulk that often accompanies steroids open to aromatization. During a cycle, the user should additionally not notice strong elevations in blood pressure, as this effect is also related (generally) to estrogen and water retention. Methenolone is a steroid most favored during cutting phases of training, when water and fat retention are major concerns, and sheer mass not the central objective.

2 - Side Effects (Androgenic):

Although classified as an anabolic steroid, androgenic side effects are still possible with this substance. This may include bouts of oily skin, acne, and body/facial hair growth. Anabolic/androgenic steroids may also aggravate male pattern hair loss. Women are warned of the potential virilizing effects of anabolic/androgenic steroids. These may include a deepening of the voice, menstrual irregularities, changes in skin texture, facial hair growth, and clitoral enlargement. Methenolone is still a very mild steroid, however, and strong androgenic side effects are typically related to higher doses. Women often find this preparation an acceptable choice, observing it to be a very comfortable and effective anabolic.

3 - Side Effects (Hepatotoxicity):

Methenolone is not considered a hepatotoxic steroid; liver toxicity is unlikely. Studies have failed to produce appreciable changes in markers of hepatic stress when the drug was given in therapeutic levels.

4 - Side Effects (Cardiovascular):

Anabolic/androgenic steroids can have deleterious effects on serum cholesterol. This includes a tendency to reduce HDL (good) cholesterol values and increase LDL (bad) cholesterol values, which may shift the HDL to LDL balance in a direction that favors greater risk of arteriosclerosis. The relative impact of an anabolic/androgenic steroid on serum lipids is dependant on the dose, route of administration (oral vs. injectable), type of steroid (aromatizable or nonaromatizable), and level of resistance to hepatic metabolism. Methenolone should have a stronger negative effect on the hepatic management of cholesterol than testosterone or nandrolone due to its non-aromatizable nature, but a much weaker impact than c-17 alpha alkylated steroids. Anabolic/androgenic steroids may also adversely affect blood pressure and triglycerides, reduce endothelial relaxation, and support left ventricular hypertrophy, all potentially increasing the risk of cardiovascular disease and myocardial infarction. To help reduce cardiovascular strain it is advised to maintain an active cardiovascular exercise program and minimize the intake of saturated fats, cholesterol, and simple carbohydrates at all times during active AAS administration. Supplementing with fish oils (4 grams per day) and a natural cholesterol/antioxidant formula such as Lipid Stabil or a product with comparable ingredients is also recommended.

5 - Side Effects (Testosterone Suppression):

All anabolic/androgenic steroids when taken in doses sufficient to promote muscle gain are expected to suppress endogenous testosterone production. Without the intervention of testosterone-stimulating substances, testosterone levels should return to normal within 1-4 months of drug secession. Note that prolonged hypogonadotrophic hypogonadism can develop secondary to steroid abuse, necessitating medical intervention. At a moderate dosage of 100-200 mg weekly, methenolone should offer measurably less testosterone suppression than an equal dose of nandrolone or testosterone, due to its non-aromatizable nature. If used for less than eight weeks, hormonal recovery should not be a protracted experience.

Methenolone Enanthate Dose:

Male:

The prescribing guidelines for Methenolone Enanthate recommend a maximum dosage of 200 mg at the onset of therapy, and a continuing dosage of 100 mg every week. Prolonged administration protocols generally call for a 100 mg dosage every 1-2 weeks, or 200 mg every 2-3 weeks. The usual administration protocols among male athletes call for a 200-400 mg per week dosage, which is taken for 6 to 12 weeks, which is sufficient to promote very noticeable increases in lean muscle tissue. It is, however, not unusual to see the drug taken in doses as high as 600 mg per week or more, although such amounts are likely to highlight a more androgenic side of methenolone, as well as exacerbate its negative effects on serum lipids. Methenolone enanthate is often stacked with other (typically stronger) steroids in order to obtain a faster and more enhanced effect. During a dieting or cutting phase, a nonaromatizing androgen like Halotestin® or trenbolone can be added. The stronger androgenic component here should help to bring about an added density and hardness to the muscles. On the other hand, one might add another mild anabolic steroid such as stanozolol. The result of such a combination should again be a notable increase in muscle mass and hardness, which still should not be accompanied by greatly increased side effects. Methenolone enanthate is also used effectively during bulking phases of training. In such a scenario, the addition of testosterone or boldenone would prove quite effective for adding new muscle mass without presenting any notable hepatotoxicity to the user.

Female:

The prescribing guidelines for Methenolone Enanthate do not offer separate dosing recommendations for women, although it was indicated that women who were pregnant, or may become pregnant, should not use the drug. Female athletes generally respond well to a dosage of 50-100 mg per week. If both oral and injectable versions are available, the oral is often given preference, as it allows for greater control over blood hormone levels. Additionally, some women choose to include Winstrol® Depot (25 mg twice per week) or Oxandrolone (7.5-10 mg daily), and with it receive a greatly enhanced anabolic effect. Androgenic activity can be a concern with such dosing, however, and should be monitored closely. If stacking, it would be best to use a much lower starting dosage for each drug than if they were to be used alone. This is especially good advice if you are unfamiliar with the effect such a combination may have on you. A popular recommendation would also be to first experiment by stacking with oral Primobolan®, and later venture into the injectable if this is still necessary.

Methenolone Enanthate Cycle:

Methenolone enanthate is an injectable form of the anabolic steroid methenolone, which is also known as Primobolan. Methenolone enanthate has a longer-lasting ester attached to it, which means it stays active in the body for a longer period compared to methenolone acetate.

A typical methenolone enanthate cycle can vary depending on individual goals, experience level, and tolerance to the compound. Here's an example of a methenolone enanthate cycle:

Week 1-12:

• Methenolone enanthate: 400-800 mg per week

Some individuals may choose to stack methenolone enanthate with other anabolic steroids or compounds to enhance results. Common compounds used in methenolone enanthate cycles include testosterone (to maintain normal physiological functions), an aromatase inhibitor (to control estrogen levels), and compounds for liver support.

Methenolone Enanthate Post-cycle therapy (PCT)

is essential after completing a methenolone enanthate cycle to help restore natural hormone production and minimize potential side effects. PCT usually includes medications such as selective estrogen receptor modulators (SERMs) like tamoxifen or aromatase inhibitors (AIs) to regulate estrogen levels and stimulate the production of testosterone.

It's crucial to remember that the use of methenolone enanthate and other anabolic steroids carries risks, including potential side effects such as liver toxicity, suppression of natural hormone production, and others. Therefore, it's essential to use these substances responsibly, under the supervision of a qualified healthcare professional, and to prioritize overall health and safety. Additionally, it's important to adhere to legal regulations regarding the use of anabolic steroids in your country or region.

Methandienone, commonly known as Dianabol or Dbol, is an orally active anabolic steroid that belongs to the class of androgenic drugs. It was developed in the 1950s by Dr. John Ziegler and released by the pharmaceutical company Ciba. Methandienone is derived from testosterone and is characterized by its strong anabolic effects, promoting muscle growth and enhancing strength.

Methandienone works by binding to androgen receptors in cells, which increases protein synthesis and nitrogen retention, leading to muscle growth and improved recovery. It also has androgenic effects, which can contribute to increased masculine characteristics such as facial hair growth and deepening of the voice.

Methandienone was originally used medically to treat conditions such as hypogonadism, certain types of anemia, and wasting syndromes. However, its medical use has declined over the years due to concerns about its side effects and the availability of safer alternatives.

Outside of medical settings, methandienone has been widely used by athletes and bodybuilders to enhance performance and improve physique. It is often used in bulking cycles to promote rapid muscle gains and strength increases. However, its use is associated with a range of potential side effects, including liver toxicity, cardiovascular issues, and suppression of natural testosterone production.

Due to its potential for misuse and adverse effects, methandienone is classified as a controlled substance in many countries and is banned by most sports organizations. It should only be used under the supervision of a qualified healthcare professional for legitimate medical purposes

Mesterolone

Description:

Similar to dihydrotestosterone, mesterolone is a strong androgen with only a weak level of anabolic activity. This is due to the fact that like dihydrotestosterone, mesterolone is rapidly reduced to inactive diol metabolites in muscle tissue where concentrations of the 3-hydroxysteroid dehydrogenase enzyme are high. The belief that the weak anabolic nature of this compound indicates a tendency to block the androgen receptor in muscle tissue, thereby reducing the gains of other more potent muscle-building steroids, should likewise not be taken seriously. In fact, due to its extremely high affinity for plasma binding proteins such as SHBG, mesterolone may actually work to potentate the activity of other steroids by displacing a higher percentage into a free, unbound state. Among athletes, mesterolone is primarily used to increase androgen levels when dieting or preparing for a contest, and as an anti-estrogen due to its intrinsic ability to antagonize the aromatase enzyme.

History:

According to company literature, Schering developed Proviron® in 1934, making this is an extremely old medication as far as anabolic/androgenic steroids. Schering also states that it was the first medication put into clinical practice for the treatment of “hormone-related diseases and complaints in men. ”Accordingly, mesterolone would have been developed around the same time as methyltestosterone (1935) and testosterone propionate (1937), which are both very old agents generally considered obsolete by today’s standards. In spite of its age, Proviron has a long history of clinical effectiveness and safety, and remains in widespread clinical use today. It is generally prescribed to males for the treatment of declining physical and mental capacity caused by age and subnormal androgen levels, low libido caused by insufficient androgen levels, hypogonadism (in pre- and post- pubescent males), and infertility (in certain situations mesterolone increases the quality and quantity of sperm). The use of mesterolone as a fertility aid is perhaps one of the most controversial indications for this drug considering that anabolic/androgenic steroids are generally linked to infertility. It is also a use of mesterolone that is quite often misunderstood by athletes. Mesterolone is applicable here because it is an effective androgen that offers minimal suppression of gonadotropins in normal therapeutic doses, not because it increases LH output. Absent gonadotropin suppression, the drug may supplement androgenicity necessary for sperm production. It is well understood that androgens have direct stimulatory effects on spermatogenesis, and also influence the transportation and maturation of sperm via effects on the epididymis, ductus deferens, and seminal vesicles. So the role of these hormones is not entirely suppressive. Mesterolone seems to have a unique positive influence on certain cases of male fertility because its potential stimulatory effects on sperm quantity and quality are not overridden by the suppression of gonadotropins. Mesterolone is widely manufactured by Bayer (formerly Schering), which currently sells the drug in more than thirty countries worldwide. The most common brand name used for its sale is Proviron, although Schering/Bayer has sold the agent under other names in certain markets, including Mestoranum and Provironum. Additionally, other manufacturers have sold mesterolone over the years, appearing under such brand names as Pluriviron (Asche, Germany), Vistimon (Jenepharm, Germany), and Restore (Brown & Burke, India). In spite of its long track record of safety and efficacy, mesterolone was never approved for sale in the United States. It remains available in many Western nations, however. Bayer remains the major (almost exclusive) global supplier of mesterolone today, although on rare occasion other brands of the drug can be located.

Structural Characteristics:

Mesterolone is a modified form of dihydrotestosterone. It differs by the addition of a methyl group at carbon 1, which helps protect the hormone from hepatic metabolism during oral administration. The same structural modification is also used with oral Primobolan® (methenolone) tablets. Alkylation at the one position slows hepatic metabolism of the steroid during the first pass, although much less profoundly than c-17 alpha alkylation. Mesterolone is resistant enough to breakdown to allow therapeutically beneficial blood levels to be achieved, although the overall bioavailability remains much lower than c-17 alpha alkylated oral steroids. Mesterolone also has a very strong binding affinity for Sex Hormone Binding Globulin.572 This may act to displace other steroids more weakly bound to SHBG into a free (active) state.

MESTEROLONE Side Effect:

1 - Side Effects (Estrogenic):

Mesterolone is not aromatized by the body, and is not measurably estrogenic. An anti-estrogen is not necessary when using this steroid, as the drug is unlikely to induce gynecomastia, water retention, or other estrogen-related side effects. Mesterolone is actually believed to act as an anti-aromatase in the body, preventing or slowing the conversion of steroids into estrogen. The result is somewhat comparable to Arimidex®, although less profound. The anti-estrogenic properties of mesterolone are not unique, and a number of other steroids have demonstrated similar activity. Dihydrotestosterone and Masteron (2-methyldihydrotestosterone), for example, have been successfully used as therapies for gynecomastia and breast cancer due to their strong androgenic and potentially anti-estrogenic effect. It has also been suggested that nandrolone may even lower aromatase activity in peripheral tissues where it is more resistant to estrogen conversion (the most active site of nandrolone aromatization seems to be the liver). The antiestrogenic effect of all of these compounds is presumably caused by their ability to compete with other substrates for binding to the aromatase enzyme. With the aromatase enzyme bound to the steroid, yet being unable to alter it, an inhibiting effect is achieved as it is temporarily blocked from interacting with other hormones.

2 - Side Effects (Androgenic):

Mesterolone is classified as an androgenic steroid. Androgenic side effects are common with this substance, especially with higher doses. This may include bouts of oily skin, acne, and body/facial hair growth. Anabolic/androgenic steroids may also aggravate male pattern hair loss. Women are also warned of the potential virilizing effects of anabolic/androgenic steroids. These may include a deepening of the voice, menstrual irregularities, changes in skin texture, facial hair growth, and clitoral enlargement. Additionally, the 5-alpha reductase enzyme does not metabolize mesterolone, so its relative androgenicity is not affected by finasteride or dutasteride.

3 - Side Effects (Hepatotoxicity):

Mesterolone is not c17-alpha alkylated, and not known to produce hepatotoxic effects; liver toxicity is unlikely.

4 - Side Effects (Cardiovascular):

Anabolic/androgenic steroids can have deleterious effects on serum cholesterol. This includes a tendency to reduce HDL (good) cholesterol values and increase LDL (bad) cholesterol values, which may shift the HDL to LDL balance in a direction that favors greater risk of arteriosclerosis. The relative impact of an anabolic/androgenic steroid on serum lipids is dependant on the dose, route of administration (oral vs. injectable), type of steroid (aromatizable or nonaromatizable), and level of resistance to hepatic metabolism. Mesterolone is an oral non-aromatizable androgen, and expected to have a notable negative effect on lipids. Studies administering 100 mg of mesterolone per day to hypogonadal men for approximately 6 months demonstrated a significant increase in total cholesterol (18.8%) and LDL cholesterol (65.2%), accompanied by a significant decrease in HDL cholesterol (-35.7%).573 Mesterolone should not be used when cardiovascular risk factors preclude the use of other oral steroids. To help reduce cardiovascular strain it is advised to maintain an active cardiovascular exercise program and minimize the intake of saturated fats, cholesterol, and simple carbohydrates at all times during active AAS administration. Supplementing with fish oils (4 grams per day) and a natural cholesterol/antioxidant formula such as Lipid Stabil or a product with comparable ingredients is also recommended.

5 - Side Effects (Testosterone Suppression):

Mesterolone has a very weak suppressive effect on gonadotropins and serum testosterone. Studies show that when given in moderate doses (150 mg per day or less), significant suppression of testosterone levels does not occur.574 In studies with higher doses (300 mg per day and above), the agent strongly suppressed serum testosterone.

MESTEROLONE Dose:

Male:

To treat androgen insufficiency, mesterolone is usually given in a dose of 1 tablet (25 mg) three times per day at the initiation of therapy. The drug is later continued at a lower maintenance dose, which usually consists of taking 1 tablet (25 mg) one to two times per day. Similar doses are used to support male fertility, usually in conjunction with other fertility drugs like injectable FSH. The usual dosage among male athletes is between 50 mg and 150 mg of mesterolone per day, or two to six 25 mg tablets. The drug is typically taken in cycles of 6-12 weeks in length, which is usually a sufficient period of time to notice the benefits of drug therapy. Many bodybuilders favor the use of mesterolone during dieting phases or contest preparation, when low estrogen and high androgen levels are particularly desirable. This is especially beneficial when anabolics like Winstrol®, Anavar, or Primobolan® are being used alone, as the androgenic content of these drugs is relatively low. Mesterolone can be effectively used here to adjust the androgen to estrogen ratio upwards, bringing about an increase in the hardness and density of the muscles, supporting libido and general sense of well being, and increasing the tendency to burn body fat. It is also commonly used (at a similar dosage) to prevent gynecomastia when other aromatizable steroids are being administered, often in conjunction with 10-20 mg per day of Nolvadex.

Female:

Mesterolone is not approved for use in women. This agent is not recommended for women for physique- or performance- enhancing purposes due to its strong androgenic nature and tendency to produce virilizing side effects. Some women do favor the drug, however, and find a single 25 mg tablet enough to efficiently shift the hormone balance in the body, greatly impacting the look of definition to the physique. Intake is usually limited to no longer than four or five weeks in such situations to minimize the chance of developing lasting virilizing effects. One tablet used in conjunction with 10 or 20 mg of Nolvadex® can be even more efficient for muscle hardening, creating an environment here the body is much more inclined to burn off extra body fat, especially in female trouble areas like the hips and thighs. Extreme caution should be taken with such use, however.

Mesterolone Cycle:

Mesterolone, also known by its brand name Proviron, is an orally active derivative of dihydrotestosterone (DHT). It's not a strong anabolic steroid but is often used in bodybuilding and athletic circles for its unique properties. Mesterolone is known for its ability to enhance libido, improve mood, and potentially reduce estrogen levels by acting as an aromatase inhibitor.

A typical Mesterolone cycle may involve its use for various purposes, including:

1. Libido Enhancement: Mesterolone is commonly used to enhance libido and sexual performance. In such cases, it may be used at a dosage of 25-50 mg per day, usually for a short duration.
2. Estrogen Control: Mesterolone can help reduce estrogen levels in the body by inhibiting aromatase enzyme activity. It may be used during a steroid cycle to mitigate estrogenic side effects such as water retention and gynecomastia. Typical dosages for estrogen control range from 25-50 mg per day.
3. Enhancing Mood and Well-being: Mesterolone is sometimes used to improve mood and overall well-being, especially during periods of intense training or when using other anabolic steroids that may have mood-altering effects. Dosages for mood enhancement are similar to those used for libido enhancement, typically ranging from 25-50 mg per day.
4. Hardening Effects: Some individuals may use Mesterolone during cutting phases to achieve a harder, more defined physique. It can be stacked with other cutting agents such as Winstrol or Anavar for synergistic effects. Dosages during cutting cycles are typically similar to those used for libido enhancement or estrogen control.

It's important to note that Mesterolone is generally considered a mild steroid with low anabolic activity. It's often used as an adjunctive therapy rather than as the primary compound in a cycle.

MESTEROLONE Post-Cycle Therapy (PCT):

Additionally, Mesterolone does not typically cause significant suppression of natural testosterone production, so it may not require extensive post-cycle therapy (PCT). However, individual responses to Mesterolone may vary, and it's always advisable to use it responsibly and under the guidance of a healthcare professional.

MGF stands for Mechano Growth Factor, which is a splice variant of insulin-like growth factor 1 (IGF-1). It is produced in response to mechanical stress or muscle damage and plays a crucial role in muscle repair and growth.

When muscles undergo mechanical stress, such as during resistance training or intense exercise, MGF is released as part of the repair and growth process. It acts locally in the damaged muscle tissue to stimulate satellite cells, which are precursor cells involved in muscle repair and regeneration. MGF promotes the proliferation and differentiation of satellite cells, leading to muscle hypertrophy (growth) and repair.

Research suggests that MGF may have potential therapeutic applications in promoting muscle growth and enhancing muscle repair, particularly in conditions associated with muscle wasting or injury. However, its use as a performance-enhancing substance is controversial and not supported by sufficient scientific evidence.

As with any peptide or hormone, the use of MGF should be approached with caution and under the supervision of a qualified healthcare professional. Its use outside of legitimate medical settings is not recommended and may carry risks and potential side effects.

Liothyronine Sodium

Description:

Liothyronine sodium is a synthetically manufactured prescription thyroid hormone. It specially consists of the Lisomer of the natural thyroid hormone triiodothyronine (T3). Thyroid hormones stimulate basal metabolic rate, and are involved with many cellular functions including protein, fat, and carbohydrate metabolism. Liothyronine sodium is used medically to treat hypothyroidism, a condition where the thyroid gland does not produce sufficient levels of thyroid hormone. Hypothyroidism is usually diagnosed with a serum hormone profile (T3, T4, & TSH), and may manifest itself with symptoms including loss of energy, lethargy, weight gain, hair loss, and changes in skin texture. T3 is the most active thyroid hormone in the body, and consequently liothyronine sodium is considered to be a more potent thyroid medication than levothyroxine sodium (T4). Bodybuilders and athletes are attracted to liothyronine sodium for its ability to increase metabolism and support the breakdown of body fat. Most often utilized during contest preparation or periods of “cutting”, the drug is usually said to significantly aid in the loss of fat, often on higher levels of caloric intake than would normally be permissive of such fat loss. To this end, the drug is also commonly used in conjunction with other fat loss agents such as human growth hormone or beta agonists. Some users also ascribe an ability of thyroid hormones like liothyronine sodium to increase the anabolic effect of steroids. While in theory these drugs may support the greater utilization of protein and carbohydrates for muscle growth, they are not widely proven or accepted for this purpose.

History:

The first medication that included T3 was technically a thyroid extract, first given to a patient with myxedema (a skin disorder associated with hypothyroidism) in 1891.695 Natural thyroid extracts contained therapeutically viable levels of the thyroid hormones T3 and T4, and were widely used in medical practice for more than 60 years. In the 1950s, however, these drugs slowly start giving way to new synthetic thyroid medications, namely liothyronine sodium and levothyroxine sodium, which were consistent in dosage and effect, and more desirable to consumers than prepared animal extracts. Although liothyronine sodium and levothyroxine sodium are both widely available in the U.S. and abroad to this day, liothyronine retains a significantly smaller portion of the global thyroid market. Given its more potent and fast acting effect, however, liothyronine sodium remains a popular thyroid drug with bodybuilders and athletes. Cytomel® is the most recognized trade name for the drug in the U.S, where it is presently sold under the King Pharmaceuticals brand name.

Structural Characteristics:

Liothyronine sodium is a synthetic form of T3 thyroid hormone. It has the chemical designation l-tyrosine,o-(4- hydroxy-3-iodophenyl)-3,5-diiodo-,monosodium salt.

Warnings:

FDA requires the following black box warning accompany prescription liothyronine sodium products sold in the U.S.: “Drugs with thyroid hormone activity, alone or together with other therapeutic agents, have been used for the treatment of obesity. In euthyroid patients, doses within the range of daily hormonal requirements are ineffective for weight reduction. Larger doses may produce serious or even life-threatening manifestations of toxicity, particularly when given in association with sympathomimetic amines such as those used for their anorectic effects.”

Side Effects:

Side effects are generally associated with overdosage, and may include headache, irritability, nervousness, sweating, irregular heartbeat, increased bowel motility, or menstrual irregularities. Overdosage may also induce shock, and may aggravate or trigger angina or congestive heart failure. Chronic overexposure to liothyronine sodium will produce symptoms normally associated with hyperthyroidism or the overproduction of natural thyroid hormones in the body.The occurrence of overexposure-linked side effects is normally cause to immediately reduce or discontinue therapy with liothyronine sodium. Acute massive overdose may be life threatening.

Dose:

When used to treat mild hypothyroidism, the typical recommended starting dosage is 25 mcg daily. The daily dosage then may be increased by no more than 25 mcg every 1 to 2 weeks. The established maintenance dose is usually 25-75 mcg per day. Once a day administration of the full daily dose is usually recommended. Although liothyronine sodium is fast acting, its effects may persist in the body for several days after discontinuance. The usual protocol among bodybuilders and athletes taking liothyronine sodium to accelerate fat loss involves initiating its use with a dosage of 25 mcg per day. This dosage may be increased by 25 mcg every 4 to 7 days, usually reaching a maximum of no more than 75 mcg per day. As in a medical setting, the intent of this slow buildup is to help the body become adjust to the increasing thyroid hormone levels, and avoid sudden changes that may initiate side effects. Cycles of liothyronine sodium usually last no longer than 6 weeks, and administration of the drug should not be halted abruptly. Instead, it is discontinued in the same slow manner in which it was initiated. This usually entails reducing the dosage by 25 mcg every 4 to 7 days. This tapering is done so that the body has time to readjust its endogenous hormone production at the conclusion of therapy, and to avoid the onset of side effects.

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LGD-4033 (VK5211, ligandrol)

Structure Characteristic:

4-[(2R)-2-[(1R)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-yl]-2-(trifluoromethyl)benzonitrile

HALF-LIFE: 24 – 36 hours

DOSE: 2.5 – 10 mg.-day

CYCLE LENGTH: 8 weeks

Description:

Ligandrol (also known as LGD-4033 and VK5211) is an extremely popular SARM, known for its ability to significantly increase muscle mass in short periods of time. It was discovered by Ligand Pharmaceuticals, but it is currently being developed by Viking Therapeutics. Like Ostarine, it was designed for the treatment of muscle wasting conditions and osteoporosis. It has gone through multiple clinical trials, which have proven it to be extremely effective at building lean muscle, even at very low doses. It was well tolerated in all studies, but it usually comes with more side-effects than weaker SARMs like Ostarine and Andarine.

Benefit:

1 - MUSCLE

Ligandrol is most people’s go-to SARM for bulking up. You can expect gains of up to 10 lbs of weight in 8 weeks. Some people report gains of up to 15 lbs. Now, unlike dry SARMs like Ostarine and Testolone, Ligandrol is known for adding water weight, meaning that not all the weight you gain will be lean muscle. You will lose 2-4 lbs of excess water after the cycle is over. Ligandrol will also increase your muscle mass on a caloric deficit, but it is rarely used in cutting cycles.

2 - STRENGTH AND PERFORMANCE

Ligandrol will increase your strength more than weaker SARMs like Ostarine and Andarine. By the end of the cycle you will be able to rep weights that you could barely rep once before the cycle. Like all SARMs, it will boost your stamina and performance in the gym. Shorter rest times between sets, the ability to do more reps and to work out for longer are to be expected. A lot of users report a feeling of euphoria, a desire to keep working out endlessly when they take LGD-4033.

3 - FAT LOSS

Contrary to what some people believe, Ligandrol will not make you lose more fat. If anything, it may make you look fatter due to the water retention it causes. However, like all SARMs, it is excellent at preserving muscle mass and even increasing it while on a caloric deficit, even though other SARMs are better choices for that purpose.

4 - BONES AND JOINTS

Ligandrol will increase the density of your bones and it will make them stronger. This has been proven to be true in clinical studies and it is one of the purposes it was designed for in the first place. It does not have the ability to heal joints and tendons that Ostarine is purported to have, but the water retention that it causes can help protect and lubricate them, making an injury less likely.

5 - RECOVERY

Ligandrol will make your recovery faster. Like with any SARM, your muscles will feel less sore the next day and it they will be ready to work out again sooner.

6 - COSMETIC BENEFITS

Ligandrol is not the SARM you want to take if your goal is to look as aesthetic as possible. It will not give your muscles the hard, dry look that most other SARMs will. The water retention can make your muscles appear less lean and blurrier. The benefit of this added water, however, is a fuller look and better pumps. If you don’t care about looking dry and you just want to fill out your clothes, Ligandrol is your best choice.

7 - Improved libido (anecdotally)

during the first 3-4 weeks after that, there was a decrease in libido, this is due to the reduction of SHBG levels prior to the suppression of testosterone.

Side Effect:

1 - TESTOSTERONE SUPPRESSION

Ligandrol, like all SARMs, will cause a significant drop in your Testosterone levels. Ligandrol is a moderately suppressive SARM, and proper measures must be taken in order to manage and reverse this suppression. The consequences of this drop in your testosterone levels can be: - Decreased libido - Weaker erections - Lethargy - Lack of motivation - Irritability - Testicular atrophy - Testicular pain The suppression of testosterone levels will be more noticeable during a cycle of Ligandrol than it will be during a cycle of Ostarine or Andarine. In fact, some users struggle so much with the drop in testosterone that they must cut their cycle short at week 6 or 7. Thankfully, there are things that can be taken in order to mitigate this side-effect. (More information on this in the chapters about On-Cycle Therapy and Post-Cycle Therapy)

It is worth noting that Ligandrol, like all SARMs, will decrease your SHBG. This will lead to an increase in your free testosterone levels which usually causes libido, motivation and well-being to improve during the first few weeks of the cycle, until the suppression of the Total Testosterone levels offsets the increase in Free Testosterone.

2 - CHOLESTEROL

Ligandrol, like all SARMs, will mess with your HDL and LDL cholesterol levels. Your HDL (good) cholesterol will be significantly decreased, and your LDL (bad) cholesterol will probably increase. This side-effect will not manifest itself by impacting the way you feel, so you will have no symptoms. Getting bloodwork at the end of a cycle will show the true impact of the SARM on your lipid panel.

3 - LGDFLU

There is a unique side-effect that apparently only Ligandrol can cause (even though there are some reports of it happening with other SARMs), commonly called “LGD flu”. This side-effect was proven to be real in a clinical trial where the participants developed the symptoms of an Upper Respiratory Tract infection for no apparent reason.

There seems to be no way to predict, avoid or manage this side-effect other than powering through this 3 to 5 day period where you will feel the symptoms of a common flu. This side-effect does not affect everyone, but a significant portion of users do report it.

4 - OTHER SIDE-EFFECTS

There are some side effects that only happen to an extremely small minority of people. For example:

Gynecomastia:

The growth of breast tissue on males. This is an extremely rare side effect that is caused by an imbalance between your estrogen and testosterone levels. Men who have had pubertal gynecomastia are at risk of developing it if they take Ligandrol.

Hair shedding:

This side effect is even rarer than the previous one, and thankfully it only seems to be temporary and completely reversible. Any substance that interferes with your hormonal levels has the potential of causing hair shedding.

Insomnia:

This is another rare side-effect that some people experience. This one is entirely unpredictable but can be mitigated easily.

— Does not cause significant fat loss as seen in clinical trials (proven in studies, with various dexascans and empirically).

— Water retention, many users experienced water retention (anecdotally proven), as said before, this cannot happen unless there is an underlying problem, due to the fact that the product is contaminated or that it is a placebo effect. As an anecdote, none of my athletes who used the same brand experienced any type of water retention according to their experience, those who used «gray» or little known brands were those who experienced some type of water retention.

— Libido problems (anecdotally proven), this is due to the inhibition of the hormonal axis and the reduction of endogenous testosterone production.

— Inhibition of the axis (proven in studies and with bloodwork).

— Elevated liver enzymes (proven in studies and with bloodwork)

Ipamorelin

Description:

Ipamorelin is a synthetic peptide that stimulates the secretion of growth hormone (GH) from the pituitary gland. It belongs to a class of compounds known as growth hormone-releasing peptides (GHRPs). Ipamorelin works by binding to and activating the ghrelin receptor (also known as the growth hormone secretagogue receptor, GHSR) in the hypothalamus and pituitary gland.

Benefit:

1. Stimulation of Growth Hormone Release: Ipamorelin promotes the release of GH in a pulsatile manner, mimicking the natural pattern of GH secretion observed in the body. This pulsatile release of GH is thought to be beneficial for maintaining optimal levels of GH in the body.
2. Selective Action: Ipamorelin is selective in its action on the ghrelin receptor, primarily stimulating the release of GH without significantly affecting the release of other hormones such as cortisol or prolactin. This selectivity may reduce the likelihood of certain side effects compared to other GH-releasing agents.
3. Metabolic Effects: In addition to its effects on GH secretion, Ipamorelin may have metabolic effects, including promoting fat loss and improving insulin sensitivity. These effects are thought to be mediated by the increase in GH and subsequent elevation of insulin-like growth factor 1 (IGF-1) levels.
4. Potential Benefits: Ipamorelin has been studied for its potential therapeutic benefits in various conditions, including growth hormone deficiency, age-related decline in GH secretion, and metabolic disorders such as obesity and insulin resistance. It has also been investigated for its potential anti-aging effects.
5. Administration: Ipamorelin is typically administered via subcutaneous injection. It is available as a synthetic peptide and is often used in research settings. However, it's important to note that Ipamorelin and other GH-releasing peptides are not approved for medical use by regulatory agencies such as the FDA in the United States.

Side Effect:

Ipamorelin is generally considered to be well-tolerated, with few reported side effects. Common side effects may include transient increases in hunger, mild water retention, and changes in cortisol levels. Long-term safety data are limited, particularly in humans.

As with any peptide or medication, it's important to use Ipamorelin under the guidance of a qualified healthcare professional. Self-administration without proper medical supervision can pose risks, and it's essential to weigh the potential benefits against the risks and to adhere to appropriate dosing and monitoring protocols

CARDARINE (GW-501516)

Structure Characteristic:

2-[2-methyl-4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5- yl]methylsulfanyl]phenoxy]acetic acid

HALF-LIFE: 24 Hours

DOSE: 10 - 20 mg.-day

CYCLE LENGTH: 8 weeks

Description:

Cardarine (also known as GW-501516 and Endurobol) is a PPARδ receptor agonist that was developed by Ligand Pharmaceuticals and GSK for the treatment of metabolic and cardiovascular diseases. Unfortunately, it was later abadoned because it was found to cause cancer in rats. Despite posing this risk, it has been used by numerous professional athletes and by tens of thousands of users for the purpose of improving endurance, burning fat and protecting the heart.

Benefit:

1 - ENDURANCE Cardarine is famous for dramatically increasing endurance and stamina overnight. Some users claim that this compound doubles their endurance and allows them to run, swim or ride a bike at a higher intensity for longer periods of time. Even though this is primarily helpful to endurance athletes, bodybuilders who do cardio with the goal of burning fat and staying healthy will also appreciate this benefit.

2 - CHOLESTEROL Cardarine will significantly improve the lipid panel by increasing HDL (good cholesterol) and lowering LDL (bad cholesterol) as well as Triglycerides. This makes Cardarine a great tool for offsetting the negative impact on the lipid panel that SARMs and steroids can cause.

3 - FAT LOSS Cardarine activates the genes that are involved in burning fat and prioritises the use of stored fat as a source of energy for the body. This makes Cardarine a great fat-burner.

— Increases slow twitch fibers.

— It significantly improves the lipid profile of the athlete.

Side Effect:

1 - The study in question involved the administration of Cardarine to Wistar Rats for 2 years. I am no expert on cancer nor do I intend to be, but if we do some research we can find out that Wistar rats have a life expectancy of up to 3 years and that they are prone to developing cancer regardless of what drug they are administered. There is a lot of discussion online about the human equivalent dose of the dose that these rats were administered. Some people claim that the human equivalent would be 200mg/day, whereas some people say it is closer to 40 mg/day. Regardless of what the real equivalent dose is, what is clear is that if one were to take Cardarine, he should not take more than 20mg/day, and he should take breaks and limit its use as much as possible.

Andarine,S-4,GTx-007

Structure Characteristic:

(2S)-3-(4-acetamidophenoxy)-2-hydroxy-2-methyl-N-[4-nitro-3- (trifluoromethyl)phenyl]propenamide

HALF-LIFE: 3 - 6 Hours

DOSE: 25 - 75 mg/day

CYCLE LENGTH: 8 – 12 weeks

Benefit:

1 - MUSCLE

While Andarine is clearly effective at building lean muscle mass, it is not what it excels at. The muscle gains one can get from Andarine are comparable to those that can be achieved with Ostarine. Like all SARMs, however, it will preserve and even increase muscle mass while on a caloric deficit.

2 - STRENGTH AND PERFORMANCE

According to anecdotal information, Andarine’s strength increase is slightly greater than that of Ostarine. Performance and stamina in the gym are also improved.

3 - FAT LOSS

Contrary to what some people claim, Andarine will not make you lose more fat. However, since it is a dry SARM, it will make you look leaner and tighter than you really are. Like all SARMs, it is excellent at keeping muscle mass and even increasing it while on a caloric deficit.

4 - BONES AND JOINTS

Andarine, like all SARMs, will increase the density and strength of your bones. It does not appear to have any impact on joints nor tendons.

5 - RECOVERY

Andarine will make your recovery faster. You will feel less sore the next day and you will be able to work out those same muscles sooner.

6 - COSMETIC BENEFITS

The cosmetic benefits of Andarine are the only reason why some people still choose to run it. This compound is known for providing a very dry, vascular and tight look. This makes Andarine a perfect choice when preparing for a Bodybuilding contest or a photoshoot. Pumps are also improved, and a more 3D look is guaranteed with this SARM.

7 - OTHER BENEFITS

Andarine, like Testolone, is effective at reducing prostate size in rats with enlarged prostates.

— It does not inhibit the hormonal axis significantly (proven with bloodwork, empirically and anecdotally).

Side Effect:

1 - TESTOSTERONE SUPPRESSION

Andarine, like all SARMs, will cause a significant drop in your Testosterone levels. Fortunately, Andarine is one of the least suppressive SARMs out there so this side effect is very manageable and easily reversible. Suppression from Andarine is comparable to that of Ostarine. The consequences of this drop in your testosterone levels can be:

- Decreased libido –

Weaker erections

- Lethargy

- Lack of motivation

- Irritability

- Testicular atrophy

- Testicular pain

Thankfully, most users do not experience more than a couple of these and only for a very limited amount of time, usually by the end of the cycle and during the first week or two after the cycle is over.

It is worth noting that Andarine, like all SARMs, will decrease your SHBG. This will lead to an increase in your free testosterone levels which usually causes libido, motivation and well-being to improve during the first few weeks of the cycle, until the suppression of the Total Testosterone levels offsets the increase in Free Testosterone.

2 - CHOLESTEROL

Andarine, like all SARMs, will mess with your HDL and LDL cholesterol levels. Your HDL (good) cholesterol will be significantly decreased, and your LDL (bad) cholesterol will probably increase. This side-effect will not manifest itself by impacting the way you feel, so you will have no symptoms. Getting bloodwork at the end of a cycle will show the true impact of the SARM on your lipid panel.

3 - VISION SIDE EFFECTS

The one thing that puts most people away from Andarine is that it affects the user’s vision. As crazy as it sounds, S-4 will give a yellowish tint to your eyes and will make adapting to changes in lighting a lot harder. Fortunately, these problems disappear after the cycle is over and according to most users, they are easy to get used to and they do not impair vision to a significant extent during the cycle. Still, this side-effect is no joke and it should not be taken lightly. Some people do not get this side-effect, but most users will, so it is safe to assume that you will too.

4 - OTHER SIDE-EFFECTS

The three side effects we just touched upon will impact almost every user, but there are some side effects that only happen to an extremely small minority of people. For example:

- Gynecomastia:

The growth of breast tissue on males. This is an extremely rare side effect that is caused by an imbalance between your estrogen and testosterone levels. Men who have had pubertal gynecomastia are at risk of developing it if they take Andarine.

- Hair shedding:

This side effect is even rarer than the previous one, and thankfully it only seems to be temporary and completely reversible. Any substance that interferes with your hormonal levels has the potential of causing hair shedding, and Andarine is no exception.

- Insomnia:

This is another rare side-effect that some people experience. This one is entirely unpredictable but can be mitigated easily.

GHRP-2

Description:

GHRP-2, or Growth Hormone Releasing Peptide-2, is a synthetic peptide belonging to the class of growth hormone-releasing peptides (GHRPs). Like other GHRPs, GHRP-2 stimulates the secretion of growth hormone (GH) from the pituitary gland.

Benefit:

1. Stimulation of Growth Hormone Release: GHRP-2 works by binding to and activating the ghrelin receptor (also known as the growth hormone secretagogue receptor, GHSR) in the hypothalamus and pituitary gland. This leads to the release of growth hormone in a pulsatile manner, mimicking the natural pattern of GH secretion observed in the body.
2. Selective Action: GHRP-2 is selective in its action on the ghrelin receptor, primarily stimulating the release of GH without significantly affecting the release of other hormones such as cortisol or prolactin. This selectivity may reduce the likelihood of certain side effects compared to other GH-releasing agents.
3. Metabolic Effects: In addition to its effects on GH secretion, GHRP-2 may have metabolic effects, including promoting fat loss and improving insulin sensitivity. These effects are thought to be mediated by the increase in GH and subsequent elevation of insulin-like growth factor 1 (IGF-1) levels.
4. Medical Uses: GHRP-2 and other GH-releasing peptides have been studied for their potential therapeutic benefits in various conditions, including growth hormone deficiency, age-related decline in GH secretion, and metabolic disorders such as obesity and insulin resistance. They have also been investigated for their potential anti-aging effects.
5. Administration: GHRP-2 is typically administered via subcutaneous injection. It is available as a synthetic peptide and is often used in research settings. However, it's important to note that GHRP-2 and other GH-releasing peptides are not approved for medical use by regulatory agencies such as the FDA in the United States.

Side Effects:

GHRP-2 is generally considered to be well-tolerated, with few reported side effects. Common side effects may include transient increases in hunger, mild water retention, and changes in cortisol levels. Long-term safety data are limited, particularly in humans.

As with any peptide or medication, it's important to use GHRP-2 under the guidance of a qualified healthcare professional. Self-administration without proper medical supervision can pose risks, and it's essential to weigh the potential benefits against the risks and to adhere to appropriate dosing and monitoring protocols.

Fluoxymesterone

BENEFIT:

Fluoxymesterone is an oral anabolic steroid derived from testosterone. More specifically, it is a methyltestosterone derivative, differing by the addition of 11-beta-hydroxy and 9-alpha-fluoro groups. The result is a potent orally active non-aromatizable steroid that exhibits extremely strong androgenic properties. Fluoxymesterone is considerably more androgenic than testosterone, while at the same time the anabolic effects of this agent are considered to be moderate in comparison. This makes fluoxymesterone a great strength drug, but not the most ideal agent for gaining muscle mass. The predominant effects seen when taking fluoxymesterone are increased strength, increased muscle density, and increased definition, with only modest size increases.

SIDE EFFECT:

1 – Estrogenic issue:

Fluoxymesterone is not aromatized by the body, and is not measurably estrogenic. An anti-estrogen is not necessary when using this steroid, as gynecomastia should not be a concern even among sensitive individuals. Since estrogen is the usual culprit with water retention, this steroid instead produces a lean, quality look to the physique with no fear of excess subcutaneous fluid retention. This makes it a favorable steroid to use during cutting cycles, when water and fat retention are major concerns.

2 – Androgenic issue:

Fluoxymesterone is classified as an androgen. Androgenic side effects are common with this substance, and may include bouts of oily skin, acne, and body/facial hair growth. Anabolic/androgenic steroids may also aggravate male pattern hair loss. Those genetically prone to male pattern hair loss may wish to opt for a milder, less androgenic, anabolic steroid. As a potent androgen, this steroid may also increase aggressiveness. Women are additionally warned of the potential virilizing effects of anabolic/androgenic steroids. These may include a deepening of the voice, menstrual irregularities, changes in skin texture, facial hair growth, and clitoral enlargement. Fluoxymesterone appears to be a good substrate for the 5- alpha reductase enzyme. This is evidenced by the fact that a large number of its metabolites are found to be 5-alpha reduced androgens,511 which coupled with its outward androgenic nature, suggests that this steroid is converting to a much more active steroid in androgen responsive target tissues such as the skin, scalp and prostate. It may be possible to reduce the relative androgenicity of fluoxymesterone by the concurrent use of finasteride or dutasteride. It is also of note that fluoxymesterone has been shown to possess usual androgenic properties. In human studies published back in 1961, the steroid displayed a much stronger tendency to promote phallic enlargement compared to other androgenic effects such as hair growth, libido, and changes in vocal pitch.512 Fluoxymesterone was offering a somewhat different androgenic profile compared to testosterone, and as such demonstrated that it was possible, at some level, to actually tailor drug effect within the broad category of androgenic action. Fluoxymesterone remains considered an androgen, but studies like the above suggest that it may not offer a complete biological equivalent to testosterone where androgenicity is concerned.

3 – Hepatotoxicity issue:

Fluoxymesterone is a c17-alpha alkylated compound. This alteration protects the drug from deactivation by the liver, allowing a very high percentage of the drug entry into the bloodstream following oral administration. C17-alpha alkylated anabolic/androgenic steroids can be hepatotoxic. Prolonged or high exposure may result in liver damage. In rare instances life-threatening dysfunction may develop. It is advisable to visit a physician periodically during each cycle to monitor liver function and overall health. Intake of c17- alpha alkylated steroids is commonly limited to 6-8 weeks, in an effort to avoid escalating liver strain. Studies administering 20 mg of fluoxymesterone to a group of nine male subjects for two weeks resulted in most patients (6/9) noticing abnormal sulfobromophthalein (BSP) retention,513 a marker of liver stress. The use of a liver detoxification supplement such as Liver Stabil, Liv-52, or Essentiale Forte is advised while taking any hepatotoxic anabolic/androgenic steroids.

4 – Cardiovascular issue:

Anabolic/androgenic steroids can have deleterious effects on serum cholesterol. This includes a tendency to reduce HDL (good) cholesterol values and increase LDL (bad) cholesterol values, which may shift the HDL to LDL balance in a direction that favors greater risk of arteriosclerosis. The relative impact of an anabolic/androgenic steroid on serum lipids is dependant on the dose, route of administration (oral vs. injectable), type of steroid (aromatizable or nonaromatizable), and level of resistance to hepatic metabolism. Fluoxymesterone has a strong effect on the hepatic management of cholesterol due to its structural resistance to liver breakdown and route of administration. Anabolic/androgenic steroids may also adversely affect blood pressure and triglycerides, reduce endothelial relaxation, and support left ventricular hypertrophy, all potentially increasing the risk of cardiovascular disease and myocardial infarction. To help reduce cardiovascular strain it is advised to maintain an active cardiovascular exercise program and minimize the intake of saturated fats, cholesterol, and simple carbohydrates at all times during active AAS administration. Supplementing with fish oils (4 grams per day) and a natural cholesterol/antioxidant formula such as Lipid Stabil or a product with comparable ingredients is also recommended.

5 - Testosterone Suppression issue:

All anabolic/androgenic steroids when taken in doses sufficient to promote muscle gain are expected to suppress endogenous testosterone production. Without the intervention of testosterone-stimulating substances, testosterone levels should return to normal within 1-4 months of drug secession. Note that prolonged hypogonadotrophic hypogonadism can develop secondary to steroid abuse, necessitating medical intervention. Studies administering 10 mg, 20 mg, or 30 mg of fluoxymesterone to nine healthy male subjects for up to 12 weeks have demonstrated the strong suppression of endogenous testosterone levels, with inconsistent effects on gonadotropin levels. Although not fully understood, fluoxymesterone is proposed to have a direct suppressive effect on testicular steroidogenesis that is not mediated by the suppression gonadotropins.

Dose:

Male:

To treat androgen insufficiency, early prescribing guidelines for fluoxymesterone called for a dose of 2-10 mg per day. Modern prescribing guidelines call for a daily dosage of 5- 20 mg. Therapy is usually initiated at the full 20 mg dosage,which is later adjusted downward to meet the individual needs of the patient. The drug would be continued long-term unless laboratory tests (lipids, liver enzymes, etc.) or side effects contraindicate its continued use. For physique- or performance-enhancing purposes, an effective oral daily dosage would fall in the range of 10-40 mg, taken in cycles lasting no more than 6-8 weeks to minimize hepatotoxicity. This level is sufficient for measurable increases in muscle strength, which may be accompanied by modest increases in lean muscle mass. Fluoxymesterone is commonly used by athletes in weightrestricted sports like wrestling, powerlifting, and boxing, due to the fact that strength gained from the drug is usually not accompanied by great increases in bodyweight. When properly used, it can allow a competitor to stay within a specified weight range, yet drastically improve his performance. Fluoxymesterone is also commonly used for bodybuilding contest preparation. When the competitor has an acceptably low body fat percentage, the strong androgen level (in absence of excess estrogen) can elicit an extremely hard and defined (“ripped”) look to the muscles. The shift in androgen/estrogen ratio additionally seems to bring about a state in which the body may be more inclined to burn off excess fat and prevent new fat storage. The “hardening” effect of fluoxymesterone would, therefore, be somewhat similar to that seen with trenbolone, although it will be without the same level of mass gain. In cutting phases, a milder anabolic such as DecaDurabolin® or Equipoise® is commonly stacked with fluoxymesterone, as they provide good anabolic effect without excessive estrogen buildup. Here, fluoxymesterone provides a well-needed androgenic component, helping to promote a more solid and defined gain in muscle mass, with less interference with energy and libido, than might be obtained with a primarily anabolic agent alone. Perhaps Primobolan®-Depot would be an even better choice, as with such a combination there is no buildup of estrogen, and likewise even less worry of water and fat retention. For mass, one might alternately use an injectable testosterone. A mix of 400 mg per week of testosterone enanthate and 20-30 mg daily of fluoxymesterone, for example, often provides exceptional increases in strength and lean muscle mass. A more significant level of androgenic side effects usually accompanies such a combination, however, as both compounds exhibit strong androgenic activity in the body.

Female:

Fluoxymesterone is most often used as a secondary medication during inoperable androgen-sensitive breast cancer, when other therapies have failed to produce a desirable effect. The dosage used for this application is 10- 40 mg per day. Virilizing effects are common at doses of only 10-15 mg per day in these patients. Fluoxymesterone is not recommended for women for physique- or performanceenhancing purposes due to its strong androgenic nature and tendency to produce virilizing side effects.

Finasteride

Description:

Finasteride is an inhibitor of 5a-reductase, which is the enzyme responsible for converting testosterone into DHT (dihydrotestosterone). This drug can efficiently reduce the serum concentration of DHT, thereby minimizing the unwanted androgenic effects that result from its presence. The effect of this drug is quite rapid, suppressing serum DHT concentrations as much as 65% within 24 hours after taking a single 1mg tablet. Medically, this drug is used to treat benign prostate hyperplasia (prostate enlargement) and androgenetic alopecia (male pattern hair loss). It is also being investigated as a potential treatment for hirsutism, which describes male patterned hair growth on the face or body of a woman. Male athletes and bodybuilders are interested in finasteride for its ability to reduce the androgenic side effects associated with the use of testosterone and certain derivatives. Finasteride is a specific inhibitor of the Type-II 5a reductase enzyme. There are actually two isozymes of reductase in the human body, labeled as Type-I and Type-II. Type-I 5areductase is predominantly found in the liver and sebaceous glands of the skin. Type-II 5a-reductase is primarily found in the prostate and hair follicles. The Type-II enzyme is responsible for about 2/3rd of the circulating DHT, while the Type-I enzyme produces the remaining 1/3rd. As an inhibitor of Type-II reductase only, finasteride has a more pronounced effect with regard to preventing hair loss, but is somewhat less effective at mitigating oily skin and acne. Since hair loss is the primary worry among most male steroid users who use reductase inhibitors, finasteride remains a popular ancillary drug in spite of its inability to block DHT conversion in all tissues. Finasteride is considered a highly specific drug, as it has little spillover effect on the other hormones in the body. It has no affinity for the androgen or estrogen receptors, and therefore does not exhibit any androgenic, antiandrogenic, estrogenic, or anti-estrogenic properties. It has no appreciable impact on circulating levels of cortisol, thyroidstimulating hormone, or thyroxine, nor does it appear to alter HDL/LDLcholesterol levels. Changes in luteinizing hormone (LH) or follicle-stimulating hormone (FSH) are also not notable, and it is not shown to have a significant effect on the hypothalamic-pituitary-testicular axis. Finasteride has been shown to increase the circulating levels of testosterone by roughly 15%, however, since a greater amount of the androgen is being left unaltered by the reductase enzyme.

History:

The first release of finasteride in the U.S. was under the brand name of Proscar® (Merck), which was approved by the FDA in 1992. It was specifically given approval for use by patients with benign prostate hyperplasia (prostate enlargement). In December 1997, the Food and Drug Administration again approved finasteride, this time for a different purpose, namely the treatment of male pattern hair loss. Merck released the drug under a different brand name for this purpose, Propecia®, which contained only 1/5th of the Proscar® dosage. Today, both Proscar® and Propecia® remain the dominant brands of finasteride on the global market.

Structural Characteristics:

Finasteride is a synthetic 4-azasteroid. It has the chemical designation 4-azaandrost-1-ene-17-carboxamide,N-(1,1- dimethylethyl)-3-oxo-,(5·,17‚)-.

Warnings (Pregnancy):

This drug must never be taken during pregnancy. Finasteride can be absorbed through the skin.Women who are, or might become pregnant, should never handle broken or uncoated finasteride tablets. The DHT blocking action of finasteride can cause severe developmental problems to an unborn male fetus, even in very small amounts. Unaltered finasteride can also be recovered in the semen.It is unknown if enough drug can be absorbed during sexual intercourse to harm a developing male fetus. The use of condoms or abstinence is recommended during therapy.

Side Effects:

Adverse reactions commonly associated with the short- term (1 year) use of finasteride include impotence (8.1%), decreased libido (6.4%), decreased ejaculate volume located. (3.7%), ejaculation disorder (.8%), gynecomastia (.5%), breast tenderness (.4%), and rash (.5%).

Administration (General Considerations):

Reductase inhibitors cannot completely protect against androgenic side effects such as steroid-induced hair loss, oily skin, and acne. Reductase inhibitors lessen these side effects by reducing, not eliminating, the level of androgenic activity in the skin and scalp. Androgenic and anabolic effects are both mediated by the same receptor, and there is no way presently known to completely separate these two properties. Dihydrotestosterone is also not unique in its ability to facilitate androgenetic alopecia (male pattern hair loss). DHT inhibition, therefore, does not offer complete protection against this side effect. Reductase inhibitors are only applicable with testosterone, methyltestosterone, and fluoxymesterone. These three drugs are converted to stronger “dihydro” derivatives by the reductase enzyme. Nandrolone and some of its derivatives become weaker upon interaction with this enzyme, as their “dihydro” metabolites bind the androgen receptor very poorly. Reductase inhibition may intensify their androgenic side effects. Methandrostenolone and boldenone undergo conversion to stronger 5-alpha reduced metabolites, but at such small levels that reductase inhibitors have little effect on their androgenicity. Most other synthetic anabolic steroids are unaffected by the reductase enzyme and reductase inhibitors.

Dose:

When used medically for the treatment of male pattern hair loss (androgenetic alopecia) in men, the recommended dosage is 1mg per day. When used for the treatment of benign prostatic hyperplasia (BPH), 5 mg per day is usually administered. When used by bodybuilders and athletes to reduce the androgenicity of testosterone, methyltestosterone, or fluoxymesterone, finasteride is commonly taken in a dosage of 1mg per day. The drug is typically administered for as long as the offending steroids are also taken. Since DHT inhibition can lessen strength and possibly muscle gains during testosterone, methyltestosterone, or fluoxymesterone therapy (given the positive actions of androgens on the neuromuscular system), a “use only when necessary” approach is usually taken with regard to this drug.

Exemestane

Description:

Exemestane is an oral medication classified as an aromatase inhibitor.

Benefit:

It is primarily used in the treatment of hormone receptor-positive breast cancer in postmenopausal women.

Aromatase inhibitors work by inhibiting the enzyme aromatase, which is responsible for converting androgens (male hormones) into estrogens (female hormones) in the body. By blocking this conversion, exemestane reduces the levels of estrogen in the body, which can help slow or stop the growth of estrogen-sensitive breast cancer cells.

Exemestane is typically prescribed for women who have gone through menopause and have already been treated with tamoxifen, another medication used in hormone receptor-positive breast cancer. It is often used as an adjuvant therapy after surgery or other treatments to reduce the risk of cancer recurrence.

Side Effect:

Like any medication, exemestane may cause side effects, which can include hot flashes, fatigue, joint pain, headache, insomnia, and increased sweating. It may also lead to bone thinning (osteoporosis) due to the reduction in estrogen levels. However, the benefits of exemestane in treating breast cancer generally outweigh the potential side effects for many patients. It should be used under the supervision of a qualified healthcare professional.

Dutasteride

Description:

Dutasteride is an inhibitor of the 5-alpha reductase enzyme. Reductase inhibitors are designed to prevent the conversion of testosterone to its more androgenic counterpart DHT (dihydrotestosterone). DHT is implicated in a number of disorders in men including male pattern hair loss and benign prostate enlargement. Dutasteride is specifically approved for the treatment of symptomatic benign prostate hyperplasia (BPH). While dutasteride is similar in structure and action to finasteride, it differs from the first generation reductase inhibitor in its tissue selectivity. Finasteride inhibits the type-2 isozyme of the 5- alpha reductase enzyme, found prominently in the scalp and prostate. Dutasteride is nonspecific for isotype, and inhibits both type-1 and type-2 reductase. As such, it inhibits DHT conversion in all tissues including the scalp, liver, prostate, and skin. Because of this it also lowers systemic levels of DHT much more effectively than finasteride. The DHT inhibiting effects of dutasteride make this drug of some interest to bodybuilders and athletes, particularly those concerned with the androgenic component of testosteronebased steroids. Dutasteride is capable of reducing the androgenic side effects produced by DHT conversion, changing the profile of testosterone drugs measurably. Provided moderate doses of testosterone are being used, the result can be a substantial reduction in the occurrence of oily skin and acne. For those prone to male pattern hair loss, dutasteride may also reduce the harsh impact of testosterone on the hairline. Note that as a selective type-2 inhibitor, finasteride is also effective at lowering DHT levels in the scalp (and reducing hairline impact of testosterone use), but does not work as well for reducing oily skin and acne. In terms of overall potency, a study published in the Journal of Clinical Endocrinology and Metabolism (May 2004) directly compared dutasteride to its closest pharmaceutical counterpart, finasteride.765 In this investigation 399 males suffering from benign prostatic hypertrophy were assembled and separated into three general groups, each receiving dutasteride (subdivided by doses of .01, .05, .5, 2.5, or 5.0 mg daily), finasteride (.5 mg daily) or placebo, for a period of 24 weeks. Over the 24- week period, the dutasteride group noted the strongest level of DHT inhibition. The beneficial effects of this drug also occurred over a wide range of dosages. For example, a 5 mg daily amount caused 98.4% inhibition in DHT levels, while 1/10th of this amount (.5 mg daily, the adopted therapeutic dose) lowered levels by an average of 94.7%. This was in great contrast to the 5 mg finasteride group, which noticed only 70.8% inhibition. Researchers also noted that there was significantly more of a variation in the results of the finasteride group, with some patients noting DHT suppression in the range of only 50-55%. Just as there can be benefits to lowering 5-alpha reductase activity by way of less androgenic side effects, there can also be some drawbacks. For one, a strong androgen like DHT helps with neuromuscular interaction, fostering strength and muscle gain. Users of reductase inhibitors often report a drop in their maximum lifts soon after the drug is initiated. Libido may also decline as DHT concentrations are lowered. A small percentage of men even find the need to keep Viagra on hand, as dutasteride renders them otherwise impotent. Dihydrotestosterone also serves as a potent endogenous antiestrogen, as this non-aromatizable steroid competes with other substrates (like testosterone, which aromatizes) to bind with the aromatase enzyme. Gynecomastia or other estrogenic side effects may occur when this competition is absent. Gynecomastia is listed in the warnings for this product, although the frequency of this in testing was very low (1.1% of users).

History:

Dutasteride was first described in 1997.766 It was developed by the U.S. based pharmaceutical company GlaxoSmithKline. It was approved by the FDA in November 2001, and introduced to market the following year by Glaxo under the Avodart trade name. GlaxoSmithKline also markets the drug in a number of other countries in Europe and South America under the same trade name.

Structural Characteristics:

Dutasteride is a synthetic 4-azasteroid. It has the chemical designation (5·,17‚)-N-{2,5 bis(trifluoromethyl)phenyl}-3- oxo-4-azaandrost-1-ene-17-carboxamide.

Warnings (Pregnancy):

This drug must never be taken during pregnancy. Be aware that dutasteride can be absorbed through the skin. Women who are, or might become pregnant, should never handle dutasteride capsules. The DHT blocking action of dutasteride can cause severe developmental problems to an unborn male fetus, even in very small amounts. Unaltered dutasteride can also be recovered in the semen. It is unknown if the drug can be absorbed during sexual intercourse enough to harm a developing male fetus. The use of condoms or abstinence is recommended during therapy.

Side Effects:

The most common adverse reactions to dutasteride therapy are impotence, reduced libido, and difficulty ejaculating. Gynecomastia was also noted during clinical trials, but occurred in less than 1% of patients. Some patients have also developed allergic reactions to the drug, including rash, itching, edema, and hives.

Administration (General Considerations):

Reductase inhibitors cannot completely protect against androgenic side effects such as steroid-induced hair loss, oily skin, and acne. Reductase inhibitors lessen these side effects by reducing, not eliminating, the level of androgenic activity in the skin and scalp. Androgenic and anabolic effects are both mediated by the same receptor, and there is presently no way known to completely separate these two properties. Dihydrotestosterone is also not unique in its ability to facilitate androgenetic alopecia (male pattern hair loss). DHT inhibition, therefore, does not offer complete protection against this side effect. Reductase inhibitors are only applicable with testosterone, methyltestosterone, and fluoxymesterone. These three drugs are converted to stronger “dihydro” derivatives by the reductase enzyme. Nandrolone and some of its derivatives become weaker upon interaction with this enzyme, as their “dihydro” metabolites bind the androgen receptor very poorly. Reductase inhibition may intensify their androgenic side effects. Methandrostenolone and boldenone undergo conversion to stronger 5-alpha reduced metabolites, but at such small levels that reductase inhibitors have little effect on their androgenicity. Most other synthetic anabolic steroids are unaffected by the reductase enzyme and reductase inhibitors.

Dose:

When used medically for the treatment of symptomatic benign prostatic hyperplasia (BPH), dutasteride is taken in a dosage of .5 mg (1 capsule) per day. When used by bodybuilders and athletes to reduce the androgenicity of testosterone, methyltestosterone, or fluoxymesterone, dutasteride is commonly taken in a dosage of .5 mg (1 capsule) once every 1-2 days. The drug is typically administered for as long as the offending steroids are also taken.

Drostanolone Enanthate

Description:

It is a synthetic anabolic-androgenic steroid (AAS) and a derivative of dihydrotestosterone (DHT). It is the enanthate ester variant of drostanolone, meaning it is attached to the drostanolone hormone to prolong its activity in the body when administered via intramuscular injection.

Drostanolone itself is known by its trade names, including Masteron.

Benefit:

Drostanolone enanthate shares many characteristics with its parent compound, including its strong androgenic and mild anabolic properties. It is primarily used in bodybuilding and athletic circles to promote muscle definition and hardness, rather than significant muscle mass gains. It's often favored by athletes and bodybuilders during cutting cycles to enhance muscle definition while reducing body fat.

As with all anabolic steroids, drostanolone enanthate is a controlled substance in many countries due to its potential for misuse, abuse, and associated health risks. Its use should be closely monitored by healthcare professionals, and it should only be used under prescription for legitimate medical conditions when deemed necessary. Misuse of drostanolone enanthate or any other AAS can lead to serious health complications

Drostanolone Propionate

Drostanolone propionate is an injectable anabolic steroid derived from dihydrotestosterone (DHT). Here, the DHT backbone has been modified with a 2-methyl group to increase its anabolic properties, making this agent significantly more effective at promoting the growth of muscle tissue than its non-methylated parent. Drostanolone propionate is described in product literature as a “steroid with powerful anabolic and anti-estrogenic properties,” and indeed does seem to share some of both properties. Admittedly, however, its anabolic properties are more properly described as moderate, especially when placed in the context of other agents. The drug is most often used by dieting bodybuilders and athletes in speed sports, where it is highly favored for its ability to produce solid increases in lean muscle mass and strength, which are usually accompanied by reductions in body fat level and minimal side effects.

Drostanolone Propionate Side Effects:

1 – Estrogenic issue:

Drostanolone is not aromatized by the body, and is not measurably estrogenic. An anti-estrogen is not necessary when using this steroid, as gynecomastia should not be a concern even among sensitive individuals. Since estrogen is the usual culprit with water retention, drostanolone instead produces a lean, quality look to the physique with no fear of excess subcutaneous fluid retention.This makes it a favorable steroid to use during cutting cycles, when water and fat retention are major concerns. As a non-aromatizable DHT derivative, drostanolone may impart an anti-estrogenic effect, the drug competing with other (aromatizable) substrates for binding to the aromatase enzyme.

2 – Androgenic issue:

Although classified as an anabolic steroid, androgenic side effects are still possible with this substance, especially with higher than normal therapeutic doses. This may include bouts of oily skin, acne, and body/facial hair growth. Anabolic/androgenic steroids may also aggravate male pattern hair loss. Women are warned of the potential virilizing effects of anabolic/androgenic steroids. These may include a deepening of the voice, menstrual irregularities, changes in skin texture, facial hair growth, and clitoral enlargement. Drostanolone is a steroid with relatively low androgenic activity relative to its tissue-building actions, making the threshold for strong androgenic side effects comparably higher than with more androgenic agents such as testosterone, methandrostenolone, or fluoxymesterone. Note that drostanolone is unaffected by the 5-alpha reductase enzyme, so its relative androgenicity is not affected by the concurrent use of finasteride or dutasteride.

3 – Hepatotoxicity issue:

Drostanolone is not c17-alpha alkylated, and not known to have hepatotoxic properties. Liver toxicity is unlikely.

4 – Cardiovascular issue:

Anabolic/androgenic steroids can have deleterious effects on serum cholesterol. This includes a tendency to reduce HDL (good) cholesterol values and increase LDL (bad) cholesterol values, which may shift the HDL to LDL balance in a direction that favors greater risk of arteriosclerosis. The relative impact of an anabolic/androgenic steroid on serum lipids is dependant on the dose, route of administration (oral vs. injectable), type of steroid (aromatizable or nonaromatizable), and level of resistance to hepatic metabolism. Drostanolone should have a stronger negative effect on the hepatic management of cholesterol than testosterone or nandrolone due to its non-aromatizable nature, but a weaker impact than c-17 alpha alkylated steroids. Anabolic/androgenic steroids may also adversely affect blood pressure and triglycerides, reduce endothelial relaxation, and support left ventricular hypertrophy, all potentially increasing the risk of cardiovascular disease and myocardial infarction. To help reduce cardiovascular strain it is advised to maintain an active cardiovascular exercise program and minimize the intake of saturated fats, cholesterol, and simple carbohydrates at all times during active AAS administration. Supplementing with fish oils (4 grams per day) and a natural cholesterol/antioxidant formula such as Lipid Stabil or a product with comparable ingredients is also recommended.

5 - Testosterone Suppression issue:

All anabolic/androgenic steroids when taken in doses sufficient to promote muscle gain are expected to suppress endogenous testosterone production. Without the intervention of testosterone-stimulating substances, testosterone levels should return to normal within 1-4 months of drug secession. Note that prolonged hypogonadotrophic hypogonadism can develop secondary to steroid abuse, necessitating medical intervention.

Drostanolone Propionate Dose:

Male:

Drostanolone propionate was not FDA approved for use in men. Prescribing guidelines are unavailable. For physiqueor performance-enhancing purposes, this drug is usually injected three times per week. The total weekly dosage is typically 200-400 mg, which is taken for 6-12 weeks. This level of use is sufficient to provide measurable gains in lean muscle mass and strength. Drostanolone propionate is often combined with other steroids for an enhanced effect. Common stacks include an injectable anabolic such as Deca-Durabolin® (nandrolone decanoate) or Equipoise® (boldenone undecylenate), which can provide notably enhanced muscle gains without excessive water retention. For mass gains, it is often combined with an injectable testosterone. The result here can be solid muscle gain, with a lower level of water retention and other estrogenic side effects than if these steroids were used alone (usually in higher doses). Drostanolone propionate, however, is most commonly applied during cutting phases of training. Here it is often combined with other non-aromatizable steroids such as Winstrol®, Primobolan®, Parabolan, or Anavar, which can greatly aid muscle retention and fat loss, during a period which can be very catabolic without steroids.

Female:

The prescribing guidelines for Drolban recommended a dose of 100 mg given three times per week. Therapy is given for a minimum of 8 to 12 weeks before an evaluation of its efficacy is made. If successful, the drug may be continued for as long as satisfactory results are obtained. Note that virilization symptoms were common at the recommended dosage. When used for physique- or performance-enhancing purposes, a dosage of 50 mg per week is most common, taken for 4 to 6 weeks. Virilization symptoms are rare in doses of 100 mg per week or below. Note that due to the short-acting nature of the propionate ester, the total weekly dosage is usually subdivided into smaller injections given once every second or third day.

Drostanolone Propionate Cycle:

Drostanolone Propionate, commonly known as Masteron, is an injectable anabolic steroid derived from dihydrotestosterone (DHT). It's valued in the bodybuilding community for its ability to provide a hard, dry look to muscles while helping to preserve lean muscle mass and enhance overall appearance.

Here's a typical cycle outline for Drostanolone Propionate:

Cycle Length: 6-10 weeks

Dosage:

• Beginner: 300-400mg per week (divided into 2-3 injections per week)
• Intermediate: 400-600mg per week (divided into 2-3 injections per week)
• Advanced: 600-800mg per week (divided into 2-3 injections per week)

Drostanolone Propionate has a relatively short half-life, so frequent injections are often necessary to maintain stable blood levels.

Drostanolone propionate is often stacked with other steroids for enhanced results. Commonly, it's used during cutting cycles alongside compounds like testosterone propionate, trenbolone acetate, or other non-aromatizing steroids to maximize its effects on muscle definition and hardness.

Drostanolone Propionate Post-cycle therapy (PCT)

is typically recommended after completing a Drostanolone propionate cycle to help restore natural testosterone production. This may involve the use of drugs like Clomid or Nolvadex.

As with any steroid cycle, it's essential to be aware of the potential side effects of Drostanolone Propionate, including but not limited to androgenic effects such as acne, hair loss, and virilization in females, as well as cardiovascular issues and suppression of natural testosterone production. Therefore, it's crucial to use Drostanolone Propionate responsibly, under the guidance of a healthcare professional, and to follow proper post-cycle therapy protocols to mitigate any adverse effects and maintain overall health and well-being

Boldenone Undecanoate

Alternative Names:

Boldenone Undecylenate

Veterinary Products:

Boldebal-H (50 mg./ml.),Equipoise (25, 50 mg./ml.),Ganabol (25, 50 mg./ml.),Pace (50 mg./ml.).Sybolin(25 mg./ml.),Vebonol (25 mg./ml.)

Description:

Boldenone undecanoate is an oil based anabolic steroid used in veterinary practice. It is highly anabolic and moderately androgenic and is not considered to be toxic to the live. Drive contains Boldenone undecanoate in addition to Methandriol Dipropionate.

BENEFIT:

Boldenone undecylenate is an injectable veterinary steroid that exhibits strong anabolic and moderately androgenic properties. The undecylenate ester extends the activity of the drug greatly (the undecylenate ester is only one carbon atom longer than decanoate), so that injections need to be repeated only once every 3 or 4 weeks. The well-balanced anabolic and androgenic properties of this drug are greatly appreciated by athletes, who generally consider it to be a stronger, slightly more androgenic, alternative to DecaDurabolin®. It is generally cheaper, and could replace Deca in most cycles without greatly changing the end result. Boldenone undecylenate is also commonly known as a drug capable of increasing red blood cell production, although there should be no confusion that this is an effect characteristic of nearly all anabolic/androgenic steroids.

SIDE EFFECT:

1 - Equipoise is commonly thought to be effective in producing rapid increases in strength and muscle mass and has also been used for ‘cutting’ prior to competition. It has a reputation for having low to moderate androgenic properties with little aromatization or water retention. Equipoise also has a reputation for increasing the appetite and for stimulating erythropoiesis.

2 – Estrogenic issue:

Boldenone is aromatized in the body to estradiol (estrogen). Elevated estrogen levels can cause side effects such as increased water retention, body fat gain, and gynecomastia. Boldenone is considered a mildly estrogenic steroid. Aromatization studies suggest that its rate of conversion to estradiol is roughly half that of testosterone.501 The tendency to develop noticeable estrogenic side effects with boldenone should be slightly higher than nandrolone, but much lower than with testosterone. Estrogenic side effects are usually not pronounced unless this drug is taken in doses above 200-400 mg per week. An anti-estrogen such as clomiphene citrate or tamoxifen citrate might be used to help mitigate these side effects, should they become present. One may alternately use an aromatase inhibitor like Arimidex® (anastrozole), although it is considerably more expensive, and may negatively affect blood lipids.

3 – Androgenic issue:

Although classified as an anabolic steroid, androgenic side effects are still common with this substance, especially with higher doses. This may include bouts of oily skin, acne, and body/facial hair growth. Anabolic/androgenic steroids may also aggravate male pattern hair loss. Women are also warned of the potential virilizing effects of anabolic/androgenic steroids. These may include a deepening of the voice, menstrual irregularities, changes in skin texture, facial hair growth, and clitoral enlargement. Note that while boldenone does reduce to a more potent androgen (dihydroboldenone) via the 5-alpha reductase enzyme in androgen-responsive target tissues such as the skin, scalp, and prostate, its affinity to do so in the human body is extremely low.502 The relative androgenicity of boldenone is, therefore, not significantly affected by finasteride or dutasteride.

4 - Hepatotoxicity issue:

Boldenone is not c-17 alpha alkylated, and not known to have hepatotoxic effects. Liver toxicity is unlikely.

5 – Cardiovascular issue:

Anabolic/androgenic steroids can have deleterious effects on serum cholesterol. This includes a tendency to reduce HDL (good) cholesterol values and increase LDL (bad) cholesterol values, which may shift the HDL to LDL balance in a direction that favors greater risk of arteriosclerosis. The relative impact of an anabolic/androgenic steroid on serum lipids is dependant on the dose, route of administration (oral vs. injectable), type of steroid (aromatizable or nonaromatizable), and level of resistance to hepatic metabolism. Anabolic/androgenic steroids may also adversely affect blood pressure and triglycerides, reduce endothelial relaxation, and support left ventricular hypertrophy, all potentially increasing the risk of cardiovascular disease and myocardial infarction. Boldenone is likely to have a less dramatic impact on cardiovascular risk factors than synthetic oral anabolic steroids. This is due in part to its openness to metabolism by the liver, which allows it to have less effect on the hepatic management of cholesterol. The aromatization of boldenone to estradiol may also help to mitigate the negative effects of androgens on serum lipids. To help reduce cardiovascular strain it is advised to maintain an active cardiovascular exercise program and minimize the intake of saturated fats, cholesterol, and simple carbohydrates at all times during active AAS administration. Supplementing with fish oils (4 grams per day) and a natural cholesterol/antioxidant formula such as Lipid Stabil or a product with comparable ingredients is also recommended.

6 - Testosterone Suppression issue:

All anabolic/androgenic steroids when taken in doses sufficient to promote muscle gain are expected to suppress endogenous testosterone production. Without the intervention of testosterone-stimulating substances, testosterone levels should return to normal within 1-4 months of drug secession. Note that prolonged hypogonadotrophic hypogonadism can develop secondary to steroid abuse, necessitating medical intervention.

Dose:

Male: 150 – 300 mg. per week.

Although it stays active for a much longer time, boldenone undecylenate is injected at least weekly for physique- or performance-enhancing purposes. It is most commonly used at a dosage of 200-400 mg (4-8ml,50 mg version) per week. The dosage schedule can be further divided to reduce the volume of each injection if necessary, perhaps administering the drug two to three times per week. One should also take caution to rotate injection sites regularly, so as to avoid irritation or infection. Not a rapid mass builder, boldenone undecylenate instead provides a slow but steady gain of strength and quality muscle mass. The positive effects of this drug become most apparent when it is used for longer cycles, usually lasting 8 weeks or more in duration. The muscle gained should also not be the smooth bulk associated with testosterone, but more defined and solid. Since water bloat is not contributing greatly to the diameter of the muscle, more of the visible size gained on a cycle of boldenone undecylenate should be retained after the drug has been discontinued. Boldenone undecylenate is a very versatile drug, and can be combined with a number of other agents depending on the desired result. For mass, it is commonly stacked with an injectable testosterone such as enanthate or cypionate. This should produce strong gains in muscle size and strength, without the same intensity of side effects of using testosterone (at a higher dose) alone. During a cutting phase, muscle hardness and density can be greatly improved when combining boldenone undecylenate with a non-aromatizable steroid such as trenbolone acetate or methenolone enanthate. Oral c-17 alpha alkylated agents such as fluoxymesterone or stanozolol may also be used, but will present some level of hepatotoxicity. For some, even the low buildup of estrogen associated with this compound is enough to relegate its use to bulking cycles only.

Female: 50 – 100 mg. per week.

When used for physique- or performance-enhancing purposes, women take much lower doses of boldenone undecylenate than men, typically 50-75 mg per week. Women should take caution with the slow-acting characteristics of this preparation, which make blood levels difficult to control and slow to decline should virilization symptoms become present.

Boldenone Undecanoate

Alternative Names:

Boldenone Undecylenate

Veterinary Products:

Boldebal-H (50 mg./ml.),Equipoise (25, 50 mg./ml.),Ganabol (25, 50 mg./ml.),Pace (50 mg./ml.).Sybolin(25 mg./ml.),Vebonol (25 mg./ml.)

Description:

Boldenone undecanoate is an oil based anabolic steroid used in veterinary practice. It is highly anabolic and moderately androgenic and is not considered to be toxic to the live. Drive contains Boldenone undecanoate in addition to Methandriol Dipropionate.

BENEFIT:

Boldenone undecylenate is an injectable veterinary steroid that exhibits strong anabolic and moderately androgenic properties. The undecylenate ester extends the activity of the drug greatly (the undecylenate ester is only one carbon atom longer than decanoate), so that injections need to be repeated only once every 3 or 4 weeks. The well-balanced anabolic and androgenic properties of this drug are greatly appreciated by athletes, who generally consider it to be a stronger, slightly more androgenic, alternative to DecaDurabolin®. It is generally cheaper, and could replace Deca in most cycles without greatly changing the end result. Boldenone undecylenate is also commonly known as a drug capable of increasing red blood cell production, although there should be no confusion that this is an effect characteristic of nearly all anabolic/androgenic steroids.

SIDE EFFECT:

1 - Equipoise is commonly thought to be effective in producing rapid increases in strength and muscle mass and has also been used for ‘cutting’ prior to competition. It has a reputation for having low to moderate androgenic properties with little aromatization or water retention. Equipoise also has a reputation for increasing the appetite and for stimulating erythropoiesis.

2 – Estrogenic issue:

Boldenone is aromatized in the body to estradiol (estrogen). Elevated estrogen levels can cause side effects such as increased water retention, body fat gain, and gynecomastia. Boldenone is considered a mildly estrogenic steroid. Aromatization studies suggest that its rate of conversion to estradiol is roughly half that of testosterone.501 The tendency to develop noticeable estrogenic side effects with boldenone should be slightly higher than nandrolone, but much lower than with testosterone. Estrogenic side effects are usually not pronounced unless this drug is taken in doses above 200-400 mg per week. An anti-estrogen such as clomiphene citrate or tamoxifen citrate might be used to help mitigate these side effects, should they become present. One may alternately use an aromatase inhibitor like Arimidex® (anastrozole), although it is considerably more expensive, and may negatively affect blood lipids.

3 – Androgenic issue:

Although classified as an anabolic steroid, androgenic side effects are still common with this substance, especially with higher doses. This may include bouts of oily skin, acne, and body/facial hair growth. Anabolic/androgenic steroids may also aggravate male pattern hair loss. Women are also warned of the potential virilizing effects of anabolic/androgenic steroids. These may include a deepening of the voice, menstrual irregularities, changes in skin texture, facial hair growth, and clitoral enlargement. Note that while boldenone does reduce to a more potent androgen (dihydroboldenone) via the 5-alpha reductase enzyme in androgen-responsive target tissues such as the skin, scalp, and prostate, its affinity to do so in the human body is extremely low.502 The relative androgenicity of boldenone is, therefore, not significantly affected by finasteride or dutasteride.

4 - Hepatotoxicity issue:

Boldenone is not c-17 alpha alkylated, and not known to have hepatotoxic effects. Liver toxicity is unlikely.

5 – Cardiovascular issue:

Anabolic/androgenic steroids can have deleterious effects on serum cholesterol. This includes a tendency to reduce HDL (good) cholesterol values and increase LDL (bad) cholesterol values, which may shift the HDL to LDL balance in a direction that favors greater risk of arteriosclerosis. The relative impact of an anabolic/androgenic steroid on serum lipids is dependant on the dose, route of administration (oral vs. injectable), type of steroid (aromatizable or nonaromatizable), and level of resistance to hepatic metabolism. Anabolic/androgenic steroids may also adversely affect blood pressure and triglycerides, reduce endothelial relaxation, and support left ventricular hypertrophy, all potentially increasing the risk of cardiovascular disease and myocardial infarction. Boldenone is likely to have a less dramatic impact on cardiovascular risk factors than synthetic oral anabolic steroids. This is due in part to its openness to metabolism by the liver, which allows it to have less effect on the hepatic management of cholesterol. The aromatization of boldenone to estradiol may also help to mitigate the negative effects of androgens on serum lipids. To help reduce cardiovascular strain it is advised to maintain an active cardiovascular exercise program and minimize the intake of saturated fats, cholesterol, and simple carbohydrates at all times during active AAS administration. Supplementing with fish oils (4 grams per day) and a natural cholesterol/antioxidant formula such as Lipid Stabil or a product with comparable ingredients is also recommended.

6 - Testosterone Suppression issue:

All anabolic/androgenic steroids when taken in doses sufficient to promote muscle gain are expected to suppress endogenous testosterone production. Without the intervention of testosterone-stimulating substances, testosterone levels should return to normal within 1-4 months of drug secession. Note that prolonged hypogonadotrophic hypogonadism can develop secondary to steroid abuse, necessitating medical intervention.

Dose:

Male: 150 – 300 mg. per week.

Although it stays active for a much longer time, boldenone undecylenate is injected at least weekly for physique- or performance-enhancing purposes. It is most commonly used at a dosage of 200-400 mg (4-8ml,50 mg version) per week. The dosage schedule can be further divided to reduce the volume of each injection if necessary, perhaps administering the drug two to three times per week. One should also take caution to rotate injection sites regularly, so as to avoid irritation or infection. Not a rapid mass builder, boldenone undecylenate instead provides a slow but steady gain of strength and quality muscle mass. The positive effects of this drug become most apparent when it is used for longer cycles, usually lasting 8 weeks or more in duration. The muscle gained should also not be the smooth bulk associated with testosterone, but more defined and solid. Since water bloat is not contributing greatly to the diameter of the muscle, more of the visible size gained on a cycle of boldenone undecylenate should be retained after the drug has been discontinued. Boldenone undecylenate is a very versatile drug, and can be combined with a number of other agents depending on the desired result. For mass, it is commonly stacked with an injectable testosterone such as enanthate or cypionate. This should produce strong gains in muscle size and strength, without the same intensity of side effects of using testosterone (at a higher dose) alone. During a cutting phase, muscle hardness and density can be greatly improved when combining boldenone undecylenate with a non-aromatizable steroid such as trenbolone acetate or methenolone enanthate. Oral c-17 alpha alkylated agents such as fluoxymesterone or stanozolol may also be used, but will present some level of hepatotoxicity. For some, even the low buildup of estrogen associated with this compound is enough to relegate its use to bulking cycles only.

Female: 50 – 100 mg. per week.

When used for physique- or performance-enhancing purposes, women take much lower doses of boldenone undecylenate than men, typically 50-75 mg per week. Women should take caution with the slow-acting characteristics of this preparation, which make blood levels difficult to control and slow to decline should virilization symptoms become present.

ACETYL L-CARNITINE 

Description:

Acetyl L-carnitine (ALCAR) is a naturally occurring compound derived from the amino acids lysine and methionine. It plays a crucial role in energy production in the body, particularly in the mitochondria, which are the energy-producing centers of cells.

Benefit:

ALCAR is known for its potential cognitive and neurological benefits, including:

1. Brain Function: It crosses the blood-brain barrier more effectively than regular L-carnitine and may enhance neurotransmitter function, leading to improved cognitive function, memory, and learning.
2. Neuroprotection: ALCAR has antioxidant properties, helping to protect neurons from oxidative damage and supporting overall brain health.
3. Energy Production: ALCAR plays a role in the transportation of fatty acids into the mitochondria, where they are converted into energy. This can potentially enhance energy levels and reduce fatigue.
4. Mood Enhancement: Some research suggests that ALCAR may have antidepressant effects by influencing neurotransmitter levels such as dopamine and serotonin.
5. Age-Related Cognitive Decline: There is some evidence to suggest that ALCAR supplementation may be beneficial in age-related cognitive decline and conditions such as Alzheimer's disease.

ALCAR is available as a dietary supplement and is often used for its potential cognitive and neurological benefits, as well as for its role in supporting energy production and overall health. However, as with any supplement, it's important to consult with a healthcare professional before starting ALCAR supplementation, especially if you have any underlying health conditions or are taking medications.

Turinabol (chlorodehydromethyltestosterone)

Chlorodehydromethyltestosterone is a potent derivative of Dianabol. This oral steroid is structurally a cross between methandrostenolone and clostebol (4-chlorotestosterone), having the same base structure as Dianabol with the added 4- chloro alteration of clostebol. This alteration makes chlorodehydromethyltestosterone a milder cousin of Dianabol, the new steroid displaying no estrogenic and a much less androgenic activity in comparison to its more famous counterpart. The anabolic activity of chlorodehydromethyltestosterone is somewhat lower than that of Dianabol as well, but it does maintain a much more favorable balance of anabolic to androgenic effect. This means that at any given level of muscle-building activity, chlorodehydromethyltestosterone will be less likely to produce androgenic side effects.

Turinabol Side Effect:

1 – Estrogenic issue:

Chlorodehydromethyltestosterone is not aromatized by the body, and is not measurably estrogenic. An anti-estrogen is not necessary when using this steroid, as gynecomastia should not be a concern even among sensitive individuals. Since estrogen is the usual culprit with water retention, this steroid instead produces a lean, quality look to the physique with no fear of excess subcutaneous fluid retention. This makes it a favorable steroid to use during cutting cycles, when water and fat retention are major concerns.

2 – Androgenic issue:

Although chlorodehydromethyltestosterone is classified as an anabolic steroid, androgenic side effects are still possible with this substance. These may include bouts of oily skin, acne, and body/facial hair growth. Doses higher than normally prescribed are more likely to cause such side effects. Anabolic/androgenic steroids may also aggravate male pattern hair loss. Women are additionally warned of the potential virilizing effects of anabolic/androgenic steroids. These may include a deepening of the voice, menstrual irregularities, changes in skin texture, facial hair growth, and clitoral enlargement. Chlorodehydromethyltestosterone is not extensively metabolized by the 5-alpha reductase enzyme, so its relative androgenicity is not greatly altered by the concurrent use of finasteride or dutasteride

3 – Hepatotoxicity issue:

Chlorodehydromethyltestosterone is a c17-alpha alkylated compound. This alteration protects the drug from deactivation by the liver, allowing a very high percentage of the drug entry into the bloodstream following oral administration. C17-alpha alkylated anabolic/androgenic steroids can be hepatotoxic. Prolonged or high exposure may result in liver damage. In rare instances life-threatening dysfunction may develop. It is advisable to visit a physician periodically during each cycle to monitor liver function and overall health. Intake of c17-alpha alkylated steroids is commonly limited to 6-8 weeks, in an effort to avoid escalating liver strain. The use of a liver detoxification supplement such as Liver Stabil, Liv-52, or Essentiale Forte is advised while taking any hepatotoxic anabolic/androgenic steroids.

4 – Cardiovascular issue:

Anabolic/androgenic steroids can have deleterious effects on serum cholesterol. This includes a tendency to reduce HDL (good) cholesterol values and increase LDL (bad) cholesterol values, which may shift the HDL to LDL balance in a direction that favors greater risk of arteriosclerosis. The relative impact of an anabolic/androgenic steroid on serum lipids is dependant on the dose, route of administration (oral vs. injectable), type of steroid (aromatizable or non- aromatizable), and level of resistance to hepatic metabolism. Chlorodehydromethyltestosterone has a strong effect on the hepatic management of cholesterol due to its nonaromatizable nature, structural resistance to liver breakdown, and route of administration. Anabolic/androgenic steroids may also adversely affect blood pressure and triglycerides, reduce endothelial relaxation, and support left ventricular hypertrophy, all potentially increasing the risk of cardiovascular disease and myocardial infarction. To help reduce cardiovascular strain it is advised to maintain an active cardiovascular exercise program and minimize the intake of saturated fats, cholesterol, and simple carbohydrates at all times during active AAS administration. Supplementing with fish oils (4 grams per day) and a natural cholesterol/antioxidant formula such as Lipid Stabil or a product with comparable ingredients is also recommended.

5 - Testosterone Suppression issue:

All anabolic/androgenic steroids when taken in doses sufficient to promote muscle gain are expected to suppress endogenous testosterone production. Without the intervention of testosterone-stimulating substances, testosterone levels should return to normal within 1-4 months of drug secession. Note that prolonged hypogonadotrophic hypogonadism can develop secondary to steroid abuse, necessitating medical intervention.

Turinabol Dose:

Male:

A common clinical dose of chlorodehydromethyltestosterone is estimated to be 5 mg per day; actual prescribing guidelines are unavailable. In the athletic arena, an effective oral daily dosage falls in the range of 15-40 mg, taken in cycles lasting no more than 6-8 weeks to minimize hepatotoxicity. This level is sufficient for measurable increases in lean muscle mass and strength. This agent is most often applied as a precontest or cutting steroid for bodybuilding purposes, and is not viewed as an ideal bulking agent due to its lack of estrogenicity. Athletes in sports where speed tends to be a primary focus also find strong favor in chlorodehydromethyltestosterone, obtaining a strong anabolic benefit without having to carry around any extra water or fat weight.

Female:

A common clinical dose of chlorodehydromethyltestosterone is estimated to be 1-2.5 mg per day; actual prescribing guidelines are unavailable. In the athletic arena, women would commonly take a single 5 mg tablet per day, taken in cycles lasting no more than 4-6 weeks to minimize hepatotoxicity. Virilizing effects are unlikely at this level of use. Much higher doses were often used with female athletes in the former GDR doping program, but often to detriment of strong virilizing side effects.

Turinabol Cycle:

Turinabol, also known as Tbol, is an oral anabolic steroid that is derived from testosterone. It was originally developed in the 1960s for therapeutic purposes, but it is now primarily used by athletes and bodybuilders to enhance performance and build muscle mass.

A typical Turinabol cycle usually lasts between 6 to 8 weeks, although some may extend it up to 10 weeks. The dosage and cycle length can vary depending on factors such as the user's experience level, goals, and tolerance to the compound. However, here is a general guideline for a beginner-level Turinabol cycle:

Week 1-8:

• Turinabol: 20-40mg per day

Some users may choose to split the daily dosage into two equal doses taken in the morning and evening to maintain stable blood levels of the steroid.

Turinabol Post-cycle therapy (PCT)

is typically recommended after completing a Turinabol cycle to help restore natural testosterone production and prevent unwanted side effects. This may include the use of drugs like Clomid or Nolvadex.

It's important to note that the use of Turinabol, like any other steroid, carries risks of side effects, including but not limited to liver toxicity, cardiovascular issues, suppression of natural testosterone production, and potential estrogenic side effects. Therefore, it's crucial to use Turinabol responsibly and under the guidance of a healthcare professional. Additionally, it's essential to follow proper post-cycle therapy protocols to help mitigate any adverse effects and maintain overall health and well-being

Somatropin

Somatropin Description:

Somatropin is a synthetic form of human growth hormone (HGH) that is identical to the naturally occurring hormone produced by the pituitary gland in the human body. It is composed of 191 amino acids, just like the endogenous human growth hormone. Somatropin is produced using recombinant DNA technology, where the human growth hormone gene is inserted into host cells (typically bacteria or yeast), which then produce the hormone.

Somatropin Benefit:

1. Treatment of growth hormone deficiency in children and adults.
2. Stimulation of growth in children who have growth failure due to a number of medical conditions, such as Turner syndrome, chronic kidney disease, or Prader-Willi syndrome.
3. Management of short stature in children born small for gestational age.
4. Treatment of muscle wasting conditions, such as HIV-associated wasting or muscle wasting due to long-term corticosteroid therapy.

Fragment 176-191, AOD-9604

Fragment 176-191 (or Frag) is exactly as the name suggests, a fragment of the full Human Growth Peptide amino acid Peptide. Particularly, the small analog region of the C-terminus end of the GH molecule which is responsible for the fat burning properties of HGH.

Fragment 176-191 Benefit:

1 - Normal HGH has negative side effects like inducing insulin resistance and downregulating endogenous HGH production. HGH Frag does not exhibit these two properties.

2 - HGH Frag can help with fat loss as well as blocking the build up of new fatty tissue. This is a very popular product if someone are not in a position to use HGH for its fat burning properties.

Description:

IGF-1 LR3, or Insulin-Like Growth Factor 1 Long R3, is a synthetic analog of insulin-like growth factor 1 (IGF-1). It is a modified version of natural IGF-1 with an extended amino acid sequence that enhances its stability and duration of action in the body.

IGF-1 is a hormone that plays a key role in regulating growth and development, particularly in children and adolescents. It is produced mainly in the liver in response to growth hormone (GH) stimulation and acts on various tissues throughout the body to promote growth, cell proliferation, and protein synthesis.

IGF-1 LR3 differs from natural IGF-1 in that it has an additional 13 amino acids at the N-terminus and the substitution of an arginine residue for a glutamic acid residue at position 3. These modifications result in a longer half-life in the bloodstream compared to native IGF-1.

IGF-1 LR3 is commonly used in scientific research to study the physiological effects of IGF-1 and its potential therapeutic applications. It is also sometimes used off-label in the fitness and bodybuilding communities for its purported ability to promote muscle growth and enhance athletic performance, although such use is controversial and not approved by regulatory authorities for non-medical purposes