Imipramine is a tricyclic antidepressant used to treat symptoms of depression and, in some cases, to prevent bed-wetting in children. Here's the information regarding its indications and dosages:

Indication:

• Depression: Imipramine is indicated for the treatment of depression. It increases the amount of serotonin and norepinephrine in the brain, substances that help regulate mood.
• Bed-Wetting (Enuresis) in Children: Imipramine is sometimes used to reduce bed-wetting in children ages 6 and older.

Dosage:

• The dosage of imipramine can vary based on the condition being treated, the severity of the symptoms, and individual patient factors.
• For adults, the typical initial dose for depression is low, and it is gradually increased to reduce the risk of side effects. The usual dosage is 1 to 4 times daily, with the possibility of taking the entire dose once daily at bedtime if daytime drowsiness occurs.
• In children, the dosage may also be based on body weight. When used for bed-wetting, imipramine should be taken one hour before bedtime. If bed-wetting occurs early in the night, the drug may be given earlier in separate doses, such as one dose in the afternoon and one dose at bedtime.
• The dosage is based on the individual's medical condition and response to treatment. It's important to follow the specific instructions provided by your healthcare provider or as indicated on the product packaging.
• It's important to note that imipramine may increase the risk of suicidal thoughts or actions in children, teenagers, and young adults. Close attention should be paid to any changes in mood, behaviors, thoughts, or feelings while taking imipramine, especially during the first few months of treatment and during dosage changes.

Please consult with a healthcare professional for comprehensive and personalized dosage recommendations for imipramine based on your specific medical condition and needs.