NATAMYCIN EYE DRP 5% (15 ML) 1 UNITS NATACYN NOVARTIS (excluded of 20 USD Postage fee/order)
Indications and Dosage
Ophthalmic
Fungal keratitis
Adult: As 5% ophthalmic susp: Instill 1 drop into the conjunctival sac of the affected eye(s) 1-2 hourly, reduce to 1 drop 6-8 times daily after 3-4 days. Duration of treatment: 2-3 weeks. Gradually reduce dose at 4-7 day intervals.
Ophthalmic
Fungal blepharitis, Fungal conjunctivitis
Adult: As 5% ophthalmic susp: Instill 1 drop into the conjunctival sac of the affected eye(s) 4-6 times daily.
Contraindications
Hypersensitivity.
Special Precautions
Patient with epithelial ulceration. Pregnancy and lactation.
Adverse Reactions
Cardiac disorders: Chest pain.
Eye disorders: Changes in vision, corneal opacity; eye discomfort, oedema, hyperaemia, irritation, pain, foreign body sensation, paraesthesia, tearing.
Immune system disorders: Allergic reaction.
Respiratory, thoracic and mediastinal disorders: Dyspnoea.
Patient Counseling Information
Avoid use of contact lenses during treatment.
Monitoring Parameters
Assess for treatment effectiveness; if no improvement after 7-10 days, re-evaluate therapy.
Action
Description:
Mechanism of Action: Natamycin, a tetraene polyene antifungal antibiotic with predominantly fungicidal activity, is derived from Streptomyces natalensis. It binds to the sterol moiety of the fungal cell membrane and alters the membrane permeability, thereby allowing the depletion of essential cellular contents.
Pharmacokinetics:
Absorption: Not expected to be absorbed systemically (ophthalmic).
Distribution: Adheres onto cornea; retained in conjunctival fornices; does not produce effective intraocular fluid levels.
Storage
Store between 2-24°C. Do not freeze. Protect from excessive heat and light.
MIMS Class
Antifungals / Eye Anti-Infectives & Antiseptics
ATC Classification
S01AA10 - natamycin ; Belongs to the class of antibiotics. Used in the treatment of eye infections.
- Model: NATACYN
- Brand: NOVARTIS